ZINC ACETATE, USP 500GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name YOHIMBINE HCL USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) 17-alpha-Hydroxy-20-alpha-yohimban-16-beta-carboxylic acid, methyl ester, hydrochloride Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Acute toxicity, Oral (Category 2), Acute toxicity, Dermal (Category 3), Acute toxicity, Inhalation (Category 3), Specif ic target organ toxicity, single exposure (Category 3) narcotic ef f ects, Specif ic target organ toxicity, repeated exposure (Category 1) cardiovascular system Signal Word Danger Hazard Statement(s) H300 Fatal if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled H336 May cause drowsiness or dizziness H372 Causes damage to organs through prolonged or repeated exposure Pictogram(s) Precautionary Statement(s) P264 Wash hands thoroughly af ter handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P301+P310 IF SWALLOWED Immediately call a POISON CENTER or doctor/physician. P302+P352 IF ON SKIN Wash with soap and water. P304+P340 IF INHALED Remove victim to fresh air and keep at rest in a position comf ortable f or breathing. P311 Call a POISON CENTER or doctor/physician. P312 Call a POISON CENTER or doctor/physician if you f eel unwell. P330 Rinse mouth. P362 Take of f contaminated clothing and wash bef ore reuse. P403+P233 Store in a well ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name 17-alpha-Hydroxy-20-alpha-yohimban-16-beta-carboxylic acid, methyl ester, hydrochloride Common Name Yohimbine Hydrochloride CAS Number 65-19-0 Impurities and/or Stabilizing Additives No data available Page 1 of 5 Section 4: First Aid Measures General Advice Remove from exposure. Remove contaminated clothing. For treatment advice, seek guidance from an occupational health physician or other licensed health-care provider f amiliar with workplace chemical exposures. In the United States, the national poison control center number is 1-800-222-1222. If person is not breathing, give artif icial respiration. If breathing is dif f icult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention. If Inhaled Remove victim to fresh air and keep at rest in a position comf ortable f or breathing. Oxygen or artif icial respiration if needed. Do not use mouth-to-mouth method if victim inhaled the substance. Induce artif icial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Call a physician or poison control center immediately. In Case of Skin Contact Take of f immediately all contaminated clothing. Wash of f with soap and plenty of water. For minor skin contact, avoid spreading material on unaf f ected skin. Call a POISON CENTER OR doctor/physicain if you f eel unwell. Get medical attention if skin irritation develops and persists. In Case of Eye Contact Rinse eyes cautiously with water f or several minutes. Get medical attention if irritation develops and persist. If Swallowed Call a physician or poison control center immediately. Rinse mouth. Do not induce vomiting without adivice from poison control center. If vomiting occurs, keep head low so that stomach content doesn't get into lungs. Do not use mouth-to- mouth method if victim ingested the substance. Induce artif icial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Most Important Symptoms and Effects Cardiovascular ef f ects. Section 5: Fire Fighting Measures Suitable Extinguishing Media Use f ire-extinguishing media appropriate f or surrounding materials. Water. Foam. Dry chemical or CO2. Special Hazards Arising From the Substance/Mixture Explosion hazard: Avoid generating dust; f ine dust dispersed in air in suf f icient concentrations and in the presence of an ignition source is a potential dust explosion hazard. No unusual f ire or explosion hazards noted. Special PPE and/or Precautions for Firefighters Wear suitable protective equipment. Use water spray to cool unopened containers. As with all f ires, evacuate personnel to saf e area. Firef ighters should use self-contained breathing equipment and protective clothing. Use standard f iref ighting procedures and consider the hazards of other involved materials. Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Dust deposits should not be allowed to accumulate on surf aces, as these may f orm an explosive mixture if they are released into the atmosphere in suf f icient concentration. Keep unnecessary personnel away. Do not touch damage containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Wear appropriate personal protective equipment. Methods and Materials Used for Containment Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of the SDS. Wash spill site. Cleanup Procedures Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of the SDS. Wash spill site. Section 7: Handling and Storage Precautions for Safe Handling As a general rule, when handling chemicals, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surf aces with suitable detergent or solvent af ter use. Af ter removing gloves, wash hands and other exposed skin thoroughly. Conditions for Safe Storage Store in tight container as def ined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Page 2 of 5 Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters No exposure standards allocated. Appropriate Engineering Controls Airborne exposures should be controlled primarily by engineering controls such as general dilution ventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generally pref erred to general exhaust because it can control the contaminant at its source, preventing dispersion into the work area. And industrial hygiene survey involving air monitoring may be used to determine the ef f ectiveness of engineering controls. Ef f ectiveness of engineering controls intended f or use with highly potent materials should be assessed by use of nontoxic surrogate materials. Local exhaust ventilation such as laboratory f ume hood or other vented enclosure is recommended, particularly f or grinding, crushing, weighing, or other dust-generating procedures. Handle in accordance with good industrial hygiene and saf ety practice. PPE - Eye/Face Protection Saf ety glasses with side shields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection is pref erred. Maintain eyewash f acilities in the work area. PPE - Skin Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. To reduce the risk of contamination of skin and surf aces, wear two pair of gloves. Remove the outer gloves af ter handling and cleanup of the material, and remove the inner gloves only af ter removing other personal protective equipment. PPE - Body Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. To reduce the risk of contamination of skin and surf aces, wear two pairs of gloves. Remove the outer gloves af ter handling and cleanup of the material, and remove the inner gloves only af ter removing other personal protective equipment. PPE - Respiratory Protection Where respirators are deemed necessary to reduce or control occupational exposures, use NIOSH-approved respiratory protection and have an ef f ective respirator program in place. Section 9: Physical and Chemical Properties Appearance Form: Powder, Physical State Solid Colour: White to yellow powder Upper/Lower Flammability or Explosive Limits No data available Odor Odorless Vapor Pressure < 0.0000001 kPa at 25 �C Odor Threshold No data available Vapor Density No data available pH 4 (10 grams/liter) Relative Density No data available Melting Point/Freezing Point 550.4 - 554 �F (288 - 290 �C) (decomposes at 302 � C) Solubility Solubility in water Slightly soluble. Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient No data available Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Section 10: Stability and Reactivity Reactivity No reactivity hazards known. Chemical Stability Stable at normal conditions. Possibility of Hazardous Reactions No dangerous reaction known under conditions of normal use. Conditions to Avoid None known Incompatible Materials Strong oxidizing agents. Hazardous Decomposition Products NOx. Cl-. Irritating and/or toxic f umes or gases. Emits toxic f umes under f ire conditions. Page 3 of 5 Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Mouse 40 mg/kg Acute Toxicity - Inhalation Toxic by inhalation. Acute Toxicity - Dermal Toxic in contact with skin. Acute Toxicity - Eye Due to lack of data the classif ication is not possible. Skin Corrosion/Irritation Due to lack of data the classif ication is not possible. Serious Eye Damage/Irritation Due to lack of data the classif ication is not possible. Respiratory or Skin Sensitazation Due to lack of data the classif ication is not possible. Germ Cell Mutagenicity Due to lack of data the classif ication is not possible. Carcinogenicity IARC This product is not considered to be a carcinogen by IARC. Carcinogenicity ACGIH No data available Carcinogenicity NTP This product is not considered to be carcinogen by NTP. Carcinogenicity OSHA This product in not considered to be carcinogen by OSHA. Reproductive Toxicity Based on available data, the classif ication criteria are not met. Epidemiological studies have not shown an association between therapeutic use of the base of this material during pregnancy and an increased incidence of birth def ects. The base of this material did not cause adverse developmental ef f ects in animal studies. Specific Target Organ Toxicity - Single Exposure Narcotic ef f ects Specific Target Organ Toxicity - Repeated Exposure Causes damage to organs (cardiovascular system) through prolonged or repeated exposure. Aspiration Hazard Based on available data, the classif ication criteria are not met. Section 12: Ecological Information Toxicity No ecotoxicity data noted f or the ingredient(s). Persistence and Degradability No data is available on the degradability of this product. Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Dispose in accordance with all applicable regulations. Under RCRA, it is the responsibility of the user of the product to determine, at the time of disposal, whether the product meets RCRA criteria f or hazardous waste. Dispose of in accordance with local regulations. Empty containers or liner may retain some product residues. This material and its container must be disposed of in a saf e manner (see Disposal instructions). Waste Treatment Methods Packaging Empty containers should be taken to an approved waste handling site f or recycling or disposal. Since emptied containers may retain product residue, f ollow label warnings even af ter container is emptied. Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number 1544 UN Proper Shipping Name Alkaloid salts, solid, n.o.s. (Yohimbine Hydrochloride) Transport Hazard Class(es) 6.1 Packaging Group II Environmental Hazards No data available Section 15: Regulatory Information US f ederal regulations CERCLA/SARA Hazardous Substances - Not applicable. All components are on the U.S. EPA TSCA Inventory List. Superf und Amendments and Reauthorization Act of 1986 (SARA) Hazard categories Immediate Hazard - Yes Delayed Hazard - No Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No SARA 302 Extremely hazardous substance No SARA 311/312 Hazardous chemical No Other f ederal regulations: Saf e Drinking Water Act. (SDWA) Not regulated. Food and Drug Administration (FDA) Not regulated US state regulations Calif ornia Saf e Drinking Water and Toxic Enf orcement Act of 1986 (Proposition 65): This material is not known to contain any chemicals currently listed as carcinogens or reproductive toxins. Page 4 of 5 Section 16: Other Information Additional Information Prepared By Lisa Russell Revision Date 01/09/2019 12:20 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 5 of 5
