VERAPAMIL HCL, USP 100GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name VERAPAMIL HCL Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) 5-[N-(3,4 Dimethoxyphenylethyl)methylamino]-2-(3,4- dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Skin irritation (Category 2), Eye irritation (Category 2), Specif ic target organ toxicity - single exposure (Category 3) Signal Word Danger Hazard Statement(s) H301 Toxic if swallowed H311 Toxic in contact with skin H331 Toxic if inhaled Pictogram(s) Precautionary Statement(s) P261 Avoid breathing dust/f ume/gas/mist/vapours/spray. P264 Wash hands thoroughly af ter handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P363 Wash contaminated clothing bef ore reuse. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name N/A Common Name Verapamil hydrochloride CAS Number 152-11-4 Impurities and/or Stabilizing Additives No data available Page 1 of 5 Section 4: First Aid Measures General Advice No data available. If Inhaled INHALED If f umes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as f alse teeth, which may block airway, should be removed, where possible, prior to initiating f irst aid procedures. Apply artif icial respiration if not breathing, pref erably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perf orm CPR if necessary. Transport to hospital, or doctor, without delay. In Case of Skin Contact SKIN If skin or hair contact occurs: Quickly but gently, wipe material of f skin with a dry, clean cloth. Immediately remove all contaminated clothing, including f ootwear. Wash skin and hair with running water. Continue f lushing with water until advised to stop by the Poisons Inf ormation Centre. Transport to hospital, or doctor. In Case of Eye Contact EYE If this product comes in contact with the eyes: Immediately hold eyelids apart and f lush the eye continuously with running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lif ting the upper and lower lids. Continue f lushing f or at least 15 minutes. Transport to hospital or doctor without delay. Removal of contact lenses af ter an eye injury should only be undertaken by skilled personnel. If Swallowed SWALLOWED If swallowed, ref er f or medical attention, where possible, without delay. Urgent hospital treatment is likely to be needed. In the mean time, qualif ied f irst-aid personnel should treat the patient f ollowing observation and employing supportive measures as indicated by the patient's condition. If the services of a medical of f icer or medical doctor are readily available, the patient should be placed in his/her care and a copy of the MSDS should be provided. Further action will be the responsibility of the medical specialist. If medical attention is not available on the worksite or surroundings send the patient to a hospital together with a copy of the SDS. Where medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: INDUCE vomiting with f ingers down the back of the throat, ONLY IF CONSCIOUS. Lean patient f orward or place on lef t side (head down position, if possible) to maintain open airway and prevent aspiration. NOTE: Wear a protective glove when inducing vomiting by mechanical means. Most Important Symptoms and Effects NOTES TO PHYSICIAN Treat symptomatically. Section 5: Fire Fighting Measures Suitable Extinguishing Media Water spray or f og.Foam. Dry chemical powder. BCF (where regulations permit). Carbon dioxide. Special Hazards Arising From the Substance/Mixture No data available Special PPE and/or Precautions for Firefighters FIRE FIGHTING Alert Fire Brigade and tell them location and nature of hazard. Wear f ull body protective clothing with breathing apparatus. Prevent, by any means available, spillage from entering drains or water course. Use f ire f ighting procedures suitable f or surrounding area. Do not approach containers suspected to be hot. Cool f ire exposed containers with water spray from a protected location. If saf e to do so, remove containers from path of f ire. Equipment should be thoroughly decontaminated af ter use FIRE INCOMPATIBILITY Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids, chlorine bleaches, pool chlorine etc. as ignition may result Personal Protective Equipment Breathing apparatus. Gas tight chemical resistant suit. Limit exposure duration to 1 BA set 30 mins. Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures MINOR SPILLS Wear protective clothing, gloves, saf ety glasses and dust respirator. MAJOR SPILLS Wear f ull body protective clothing with breathing apparatus. Methods and Materials Used for Containment MINOR SPILLS Clean up waste regularly and abnormal spills immediately. Avoid breathing dust and contact with skin and eyes. Wear protective clothing, gloves, saf ety glasses and dust respirator. Use dry clean up procedures and avoid generating dust. Vacuum up or sweep up. NOTE: Vacuum cleaner must be f itted with an exhaust micro f ilter (HEPA type) (consider explosion-proof machines designed to be grounded during storage and use). Dampen with water to prevent dusting bef ore sweeping. Place in suitable containers f or disposal. MAJOR SPILLS Clear area of personnel and move upwind. Alert Fire Brigade and tell them location and nature of hazard. Wear f ull body protective clothing with breathing apparatus. Prevent, by any means available, spillage from entering drains or water course. Stop leak if saf e to do so. Contain spill with sand, earth or vermiculite. Collect recoverable product into labeled containers f or recycling. Neutralize/decontaminate residue. Collect solid residues and seal in labeled drums f or disposal. Wash area and prevent runof f into drains. Cleanup Procedures MINOR SPILLS Clean up waste regularly and abnormal spills immediately. Avoid breathing dust and contact with skin and eyes. Wear protective clothing, gloves, saf ety glasses and dust respirator. Use dry clean up procedures and avoid generating dust. Vacuum up or sweep up. NOTE: Vacuum cleaner must be f itted with an exhaust micro f ilter (HEPA type) (consider explosion-proof machines designed to be grounded during storage and use). Dampen with water to prevent dusting bef ore sweeping. Place in suitable containers f or disposal. MAJOR SPILLS Clear area of personnel and move upwind. Alert Fire Brigade and tell them location and nature of hazard. Wear f ull body protective clothing with breathing apparatus. Prevent, by any means available, spillage from entering drains or water course. Stop leak if saf e to do so. Contain spill with sand, earth or vermiculite. Collect recoverable product into labeled containers f or recycling. Neutralize/decontaminate residue. Collect solid residues and seal in labeled drums f or disposal. Wash area and prevent runof f into drains. Page 2 of 5 Section 7: Handling and Storage Precautions for Safe Handling Avoid all personal contact, including inhalation. Wear protective clothing when risk of exposure occurs. Use in a wellventilated area. Prevent concentration in hollows and sumps. DO NOT enter conf ined spaces until atmosphere has been checked. DO NOT allow material to contact humans, exposed f ood or f ood utensils. Avoid contact with incompatible materials. When handlings, DO NOT eat, drink or smoke. Keep containers securely sealed when not in use. Avoid physical damage to containers. Always wash hands with soap and water af ter handling. Work clothes should be laundered separately. Launder contaminated clothing bef ore reuse. Use good occupational work practice. Observe manuf acturer's storing and handling recommendations. Atmosphere should be regularly checked against established exposure standards to ensure saf e working conditions are maintained. Empty containers may contain residual dust which has the potential to accumulate f ollowing settling. Such dusts may explode in the presence of an appropriate ignition source. Do NOT cut, drill, grind or weld such containers. In addition ensure such activity is not perf ormed near f ull, partially empty or empty containers without appropriate workplace saf ety authorization or permit. Conditions for Safe Storage STORAGE INCOMPATIBILITY Avoid reaction with oxidizing agents May decompose on exposure to heat and light. STORAGE REQUIREMENTS Store in original containers. Keep containers securely sealed. Store in a cool, dry, wellventilated area. Store away from incompatible materials and f oodstuf f containers. Protect containers against physical damage and check regularly f or leaks. Observe manuf acturer's storing and handling recommendations. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters INTERNAL - OEL 8 hrs TWA - 50 mcg/m3 STEL Not Established Appropriate Engineering Controls Unless written procedures, specif ic to the workplace are available, the f ollowing is intended as a guide: HEPA terminated local exhaust ventilation should be considered at point of generation of dust, f umes or vapours. Supplied air respirator should be considered High-energy operations such as milling, particle sizing, spraying or f luidising should be done within an approved emission control or containment system. Develop cleaning procedures and techniques that limit potential exposure PPE - Eye/Face Protection saf ety glasses PPE - Skin Protection Wear appropriate gloves; lab coat, coveralls or disposable Tyvek suit saf ety shoes, and disposable booties. PPE - Body Protection Wear appropriate gloves; lab coat, coveralls or disposable Tyvek suit saf ety shoes, and disposable booties. PPE - Respiratory Protection Supplied air respirator should be considered Section 9: Physical and Chemical Properties Appearance Physical state: Solid. Color: White Upper/Lower Flammability or Explosive Limits NA Odor odorless Vapor Pressure NA Odor Threshold NA Vapor Density NA pH 4.5-5.0 5% soln Relative Density NA Melting Point/Freezing Point 491.05 Solubility Solubility water: Miscible Initial Boiling Point and Boiling Range NA Flash Point NA Evaporation Rate NA Flammability (Solid, Gas) NA Partition Coefficient NA Auto-Ignition Temperature NA Decomposition Temperature NA Viscosity No data available Page 3 of 5 Section 10: Stability and Reactivity Reactivity No data available Chemical Stability Product is considered stable. Possibility of Hazardous Reactions No data available Conditions to Avoid Avoid reaction with oxidizing agents Incompatible Materials Oxidizing agents Hazardous Decomposition Products May decompose on exposure to heat and light. Hazardous polymerization will not occur. Section 11: Toxicological Information Acute Toxicity - LD50 Oral Oral (rat) LD50 100 mg/kg Intraperitoneal (rat) LD50 60 mg/kg Subcutaneous (rat) LD50 107 mg/kg Intravenous (rat) LD50 16 mg/kg Intramuscular (rat) LD50 47 mg/kg Oral (mouse) LD50 163 mg/kg Intraperitoneal (mouse) LD50 41 mg/kg Subcutaneous (mouse) LD50 68 mg/kg Intravenous (mouse) LD50 5.795 mg/kg Intramuscular (mouse) LD50 45 mg/kg Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal No data available Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation No data available Germ Cell Mutagenicity No data available Carcinogenicity IARC No data available Carcinogenicity ACGIH No data available Carcinogenicity NTP No data available Carcinogenicity OSHA No data available Reproductive Toxicity No data available Specific Target Organ Toxicity - Single Exposure No data available Specific Target Organ Toxicity - Repeated Exposure No data available Aspiration Hazard No data available Section 12: Ecological Information Toxicity No data available. DO NOT discharge into sewer or waterways Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Containers may still present a chemical hazard/ danger when empty. Return to supplier f or reuse/ recycling if possible. Otherwise: If container can not be cleaned suf f iciently well to ensure that residuals do not remain or if the container cannot be used to store the same product, then puncture containers, to prevent re-use, and bury at an authorized landf ill. Where possible retain label warnings and MSDS and observe all notices pertaining to the product. Legislation addressing waste disposal requirements may dif f er by country, state and/ or territory. Each user must ref er to laws operating in their area. In some areas, certain wastes must be tracked. A Hierarchy of Controls seems to be common - the user should investigate: Reduction Reuse Recycling Disposal (if all else f ails) Waste Treatment Methods Packaging Containers may still present a chemical hazard/ danger when empty. Return to supplier f or reuse/ recycling if possible. Otherwise: If container can not be cleaned suf f iciently well to ensure that residuals do not remain or if the container cannot be used to store the same product, then puncture containers, to prevent re-use, and bury at an authorized landf ill. Where possible retain label warnings and MSDS and observe all notices pertaining to the product. Legislation addressing waste disposal requirements may dif f er by country, state and/ or territory. Each user must ref er to laws operating in their area. In some areas, certain wastes must be tracked. A Hierarchy of Controls seems to be common - the user should investigate: Reduction Reuse Recycling Disposal (if all else f ails) Special Precautions Landfill or Incinerations No data available Other Information No data available Page 4 of 5 Section 14: Transport Information UN Number 2811 UN Proper Shipping Name Toxic solids, organic, n.o.s. (Verapamil hydrochloride) Transport Hazard Class(es) 6.1 Packaging Group III Environmental Hazards No data available Section 15: Regulatory Information No data available Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/09/2019 12:33 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 5 of 5
