VANCOMYCIN HCL, USP 500GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name VANCOMYCIN HCL USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) Vancomycin monohydrochloride Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Serious eye damage/eye irritation Category 2A, Sensitization, skin Category 1 Signal Word Warning Hazard Statement(s) H317 May cause an allergic skin reaction H319 Causes serious eye irritation Pictogram(s) Precautionary Statement(s) P264 Wash hands thoroughly af ter handling. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P302+P352 IF ON SKIN Wash with soap and water. P305+P351+P338 IF IN EYES Rinse cautiously with water f or several minutes. Remove contact lenses if present and easy to do. continue rinsing. P333+P313 If skin irritation or a rash occurs Get medical advice/attention. P337+P313 If eye irritation persists Get medical advice/attention. P363 Wash contaminated clothing bef ore reuse. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name Vancomycin Hydrochloride Common Name Vancomycin Hydrochloride CAS Number 1404-93-9 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No inf ormation available. If Inhaled Move to fresh air. Call a physician if symptoms develop or persist. In Case of Skin Contact Rinse skin with water/shower. Get medical attention if irritation develops and persists. In Case of Eye Contact Rinse cautiously with water f or several minutes. Get medical attention if irritation develops and persists. If Swallowed Rinse mouth. Get medical attention if symptoms occur. Most Important Symptoms and Effects No data available Section 5: Fire Fighting Measures Suitable Extinguishing Media Water spray, dry chemical, carbon dioxide, or f oam as appropriate f or surrounding f ire and materials. Cool containers exposed to f lames with water until well af ter the f ire is out. Special Hazards Arising From the Substance/Mixture No unusual f ire or explosion hazards noted. Special PPE and/or Precautions for Firefighters Wear suitable protective equipment. As with all f ires, evacuate personnel to a saf e area. Firef ighters should use selfcontained breathing equipment and protective clothing. Page 1 of 4 Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Keep unnecessary personnel away. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of dust from the spilled material. Wear appropriate personal protective equipment. Methods and Materials Used for Containment Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of the SDS. Wash spill site. Cleanup Procedures Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of the SDS. Wash spill site. Section 7: Handling and Storage Precautions for Safe Handling As a general rule, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surf aces with suitable detergent or solvent af ter use. Af ter removing gloves, wash hands and other exposed skin thoroughly. Use of a designated area is recommended f or handling of potent materials. Conditions for Safe Storage Preserve in airtight containers, protect from light, and store at 2 - 8 �??�?°C. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Vancomycin Hydrochloride TWA 100 micrograms/m3 (CAS 1404-93-9) Appropriate Engineering Controls Handle in accordance with good industrial hygiene and saf ety practice. Wash hands bef ore breaks and at the end of workday. PPE - Eye/Face Protection Saf ety glasses with side shields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Maintain eyewash f acilities in the work area. PPE - Skin Protection Chemical resistant gloves (nitrile or latex) and body covering. PPE - Body Protection Chemical resistant gloves (nitrile or latex) and body covering. PPE - Respiratory Protection Where respirators are deemed necessary to reduce or control occupational exposures, use an approved respirator suitable to provide level of protection required. Section 9: Physical and Chemical Properties Appearance White or almost white powder. Upper/Lower Flammability or Explosive Limits No data available Odor Odorless Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH 2.5-4.5 (5% aqueous solution) Relative Density No data available Melting Point/Freezing Point No data available Solubility No data available Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient No data available Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Section 10: Stability and Reactivity Reactivity No reactivity hazards known. Chemical Stability Stable under recommended storage conditions. Possibility of Hazardous Reactions No data available Conditions to Avoid None known. Incompatible Materials Strong oxidizing agents. Alkaline solutions. Hazardous Decomposition Products Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas. Page 2 of 4 Section 11: Toxicological Information Acute Toxicity - LD50 Oral Based on available data, the classif ication criteria are not met. LD50 Oral - Mouse - > 5g/kg, Rat - > 10 g/kg. Acute Toxicity - Inhalation LC50 Rat 3080 mg/kg, 1 hr Acute Toxicity - Dermal No data available Acute Toxicity - Eye Causes serious eye irritation Skin Corrosion/Irritation Based on available data, the classif ication criteria are not met. Serious Eye Damage/Irritation Causes serious eye irritation Respiratory or Skin Sensitazation Due to lack of data the classif ication is not possible. Germ Cell Mutagenicity Based on available data, the classif ication criteria are not met. In vivo and in vitrol mutagenicity studies were negative in a related material. Carcinogenicity IARC Due to lack of data the classif ication is not possible. This product is not considered to be a carcinogen by IARC. Carcinogenicity ACGIH Due to lack of data the classif ication is not possible. This product is not considered to be a carcinogen by ACGIH. Carcinogenicity NTP Due to lack of data the classif ication is not possible. This product is not considered to be a carcinogen by NTP. Carcinogenicity OSHA Due to lack of data the classif ication is not possible. This product is not considered to be a carcinogen by OSHA. Reproductive Toxicity Based on available data, the classif ication criteria are not met. In animal studies, a related material did not cause birth def ects or adverse developmental ef f ects. Specific Target Organ Toxicity - Single Exposure Due to lack of data the classif ication is not possible. Specific Target Organ Toxicity - Repeated Exposure Due to lack of data the classif ication is not possible. Aspiration Hazard Based on available data, the classif ication criteria are not met. Section 12: Ecological Information Toxicity No data available Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Disposal (includes Spills, Empty Containers): Dispose of any cleanup materials and waste residue according to applicable laws and regulations. Waste Treatment Methods Packaging Disposal (includes Spills, Empty Containers): Dispose of any cleanup materials and waste residue according to applicable laws and regulations. Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number Not dangerous goods. UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards N/A Section 15: Regulatory Information This product is a "Hazardous Chemical" as def ined by the OSHA Hazard Communication Standard 29 CFR 1910.1200. CERCLA/SARA Hazardous Substances-Not applicable. One or more components are not listed on TSCA. Superf und Amendments and Reauthorization Act of 1986 (SARA): Hazard categories: Immediate Hazard -Yes, Delayed hazard - No, Fire Hazard - No, Pressure Hazard - No, Reactivity Hazard - No. SARA 302 Extremely hazardous substance: No. SARA 311/312 Hazardous chemical: No. Other f ederal regulations: Saf e Drinking Water Act (SDWA): Not regulated. US state regulations: This product does not contain a chemical known to the State of Calif ornia to cause cancer, birth def ects or other reproductive harm. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/09/2019 12:43 Page 3 of 4 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
