NEOMYCIN SULFATE, USP 500GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name NEOMYCIN SULFATE USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) Neomycin B sulf ate Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Skin corrosion/irritation (Category 2), Serious eye damage/eye irritation (Category 2B), Sensitization, Skin (Category 1), Reproductive toxicity (Category 1) Signal Word Danger Hazard Statement(s) H315 Causes skin irritation H317 May cause an allergic skin reaction H320 Causes eye irritation H360 May damage f ertility or the unborn child Pictogram(s) Precautionary Statement(s) P201 Obtain special instructions bef ore use. P202 Do not handle until all saf ety precautions have been read and understood. P264 Wash hands thoroughly af ter handling. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P302+P352 IF ON SKIN Wash with soap and water. P305+P351+P338 IF IN EYES Rinse cautiously with water f or several minutes. Remove contact lenses if present and easy to do. continue rinsing. P308+P313 IF exposed or concerned Get medical advice/attention. P333+P313 If skin irritation or a rash occurs Get medical advice/attention. P337+P313 If eye irritation persists Get medical advice/attention. P362 Take of f contaminated clothing and wash bef ore reuse. P405 Store locked up. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name Neomycin B sulf ate Common Name Neomycin Sulf ate CAS Number 1405-10-3 Impurities and/or Stabilizing Additives No data available Page 1 of 4 Section 4: First Aid Measures General Advice Remove from exposure. Remove contaminated clothing. For treatment advice, seek guidance from an occupational health physician or other licensed health-care provider f amiliar with workplace chemical exposures. In the United States, the national poison control number is 1-800-222-1222. If person is not breathing, give artif icial respiration. If breathing is dif f icult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention. If Inhaled Move to fresh air. Call a physician if symptoms develop or persist. In Case of Skin Contact Remove contaminated clothing. Wash of f with soap and plenty of water. Rinse skin with water/shower. For minor skin contact, avoid spreading material on unaf f ected skin. Get medical attention if irritation develops and persists. If skin irritation or rash occurs: Get medical advice/attention. In Case of Eye Contact Rinse cautiously with water f or several minutes. Rinse with water. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical attention if irritation develops and persists. If Swallowed Call a POISON CENTER or doctor/physician if you f eel unwell. Rinse mouth. If ingestion of a large amount does occur, call a poison control center immediately. Most Important Symptoms and Effects May cause allergic skin reaction. Irritation of eyes, skin, an mucous membranes. Treatment of aminoglycoside overdose is symptomatic and supportive and may include: Administer activated charcoal as a slurry. For mild/moderate allergic reactions, administer antihistamines with or without inhaled beta agonists, corticosteroids or epinephrine; f or severe reactions add aggressive airway management, oxygen, ECG monitoring, and intravenous f luids. Maintain urine output with IV f luids in patients with normal renal f unction. Consider dialysis in patients with renal f ailure. Complexation with intravenous ticarcillin may be ef f ective. (Meditext) Section 5: Fire Fighting Measures Suitable Extinguishing Media Use f ire-extinguishing media appropriate f or surrounding materials. Water. Foam. Dry chemical or CO2. Special Hazards Arising From the Substance/Mixture No unusual f ire or explosion hazards noted. Special PPE and/or Precautions for Firefighters Wear suitable protective equipment. Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Keep unnecessary personnel away. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of dust from the spilled material. Wear appropriate personal protective equipment. Methods and Materials Used for Containment Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of SDS. Clean surf ace thoroughly to remove residual contamination. Cleanup Procedures Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. For waste disposal, see section 13 of SDS. Clean surf ace thoroughly to remove residual contamination. Section 7: Handling and Storage Precautions for Safe Handling As a general rule, when handling chemicals, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surf aces with suitable detergent or solvent af ter use. Af ter removing gloves, wash hands and other exposed skin thoroughly. Conditions for Safe Storage Store in a tight container as def ined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Material: Neomycin Sulf ate (CAS 1405-10-3) Type: TWA Value 1000 micrograms/m3 Appropriate Engineering Controls Airborne exposure should be controlled primarily by engineering controls such as general dilution ventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generally pref erred to general exhaust because it can control the contaminant at its source, preventing dispersion into the work area. An industrial hygiene survey involving air monitoring may be used to determine the ef f ectiveness of engineering controls. Ef f ectiveness of engineering controls intend f or use with highly potent materials should be assessed by use of nontoxic surrogate materials. Local exhaust ventilation such as laboratory f ume hood or other vented enclosure is recommended, particularly f or grinding, crushing, weighing, or other dust-generating procedures. PPE - Eye/Face Protection Saf ety glasses with sideshields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection (e.g. bearing the ANSI Z87 or CSA Stamp) is pref erred. Maintain eyewash f acilities in the work area. PPE - Skin Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. PPE - Body Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. For handling of laboratory scale quantities, a cloth lab coat is recommended. Where signif icant quantities are handled, work clothing may be necessary to prevent take-home contamination. PPE - Respiratory Protection Where respirators are deemed necessary to reduce or control occupational exposures, use NIOSH-approved respiratory protection and have an ef f ective respirator program in place. Page 2 of 4 Section 9: Physical and Chemical Properties Appearance Form: Solid, Powder Colour: White to slightly yellow powder Upper/Lower Flammability or Explosive Limits No data available Odor Odorless or almost odorless Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH 5 - 7.5 (3.3% aqueous solution) Relative Density No data available Melting Point/Freezing Point No data available Solubility Solubility in water Freely soluble Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient < -2 Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Section 10: Stability and Reactivity Reactivity No reactivity hazards known. Chemical Stability Material is stable under normal conditions. Possibility of Hazardous Reactions No dangerous reaction known under conditions of normal use. Conditions to Avoid None known. Incompatible Materials Acids Hazardous Decomposition Products Irritating and/or toxic f umes or gases. Emits toxic f umes under f ire conditions. SOx. NOx. Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Oral Mouse 2880 mg/kg Rat 2750 mg/kg Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal No data available Acute Toxicity - Eye Causes eye irritation. Skin Corrosion/Irritation Causes skin irritation. Serious Eye Damage/Irritation Causes eye irritation Respiratory or Skin Sensitazation Due to lack of data the classif ication is not possible. May cause an allergic skin reaction. Germ Cell Mutagenicity Data from germ cell mutagenicity tests were not f ound. Due to lack of data the classif ication is not possible. Carcinogenicity IARC This material is not considered to be carcinogen by IARC. Carcinogenicity ACGIH This product is not considered to be carcinogen by ACGIH. Carcinogenicity NTP This product is not considered to be carcinogen by NTP. Carcinogenicity OSHA This product in not considered to be carcinogen by OSHA. Reproductive Toxicity May damage f ertility or the unborn child. Therapeutic use of aminoglycosides during pregnancy has been reported to cause kidney damage and deaf ness in the human f etus. Specific Target Organ Toxicity - Single Exposure Due to lack of data the classif ication is not possible. Specific Target Organ Toxicity - Repeated Exposure Due to lack of data the classif ication is not possible. Aspiration Hazard Based on available data, the classif ication criteria are not met. Page 3 of 4 Section 12: Ecological Information Toxicity Contains a substance which causes risk of hazardous ef f ects to the environment. Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Dispose in accordance with all applicable regulations. Under RCRA, it is the responsibility of the user of the product to determine, at the time of disposal, whether the product meets RCRA criteria f or hazardous waste. Waste Treatment Methods Packaging Dispose of in accordance with local regulations. Empty containers or liners may retain some product residues. This material and its container must be disposed on in a saf e manner (see Disposal instructions). Empty containers should be taken to an approved waste handling site f or recycling or disposal. Since emptied containers may retain product residue, f ollow label warnings even af ter container is emptied. Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number Not regulated as a hazardous material by DOT. UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards N/A Section 15: Regulatory Information US f ederal regulations CERCLA/SARA Hazardous Substances - Not applicable. All components are on the U.S. EPA TSCA Inventory List. Superf und Amendments and Reauthorization Act of 1986 (SARA) Hazard categories Immediate Hazard - Yes Delayed Hazard - Yes Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No SARA 302 Extremely hazardous substance: No SARA 311/312 Hazardous chemical: No Other f ederal regulations Saf e Drinking Water Act (SDWA) Not regulated. Food and Drug Administration (FDA) Not regulated. US state regulations WARNING: This product contains a chemical known to the State of Calif ornia to cause birth def ects or other reproductive harm. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/10/2019 12:16 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
