GLYCYRRHIZIC ACID 1KG by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name Glycyrrhizic Acid Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) Glycyrrhizin Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Not classif ied Signal Word None Hazard Statement(s) N/A Pictogram(s) N/A Precautionary Statement(s) N/A Hazards Not Otherwise Classified Not classif ied Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name Glycyrrhizic Acid Common Name Glycyrrhizin CAS Number 1405-86-3 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice Remove from exposure. Remove contaminated clothing. For treatment advice, seek guidance from an occupational health physician or other licensed health-care provider f amiliar with workplace chemical exposures. In the United States, the national poison control center phone number is 1-800-222-1222. If person is not breathing, give artif icial respiration. If breathing is dif f icult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic) reactions must receive immediate medical attention. If Inhaled If breathing is dif f icult, remove to fresh air and keep at rest in a position comf ortable f or breathing. Call a physician if symptoms develop or persist. In Case of Skin Contact Rinse skin with water/shower. Get medical attention if irritation develops and persists. In Case of Eye Contact Rinse with water. Get medical attention if irritation develops and persists. If Swallowed Rinse mouth. If ingestion of a large amount does occur, call a poison control center immediately. Most Important Symptoms and Effects Not available Section 5: Fire Fighting Measures Suitable Extinguishing Media Suitable extinguishing media Water spray, dry chemical, carbon dioxide, or f oam as appropriate f or surrounding f ire and materials. Unsuitable extinguishing media None known. Cool containers exposed to f lames with water until well af ter the f ire is out. Special Hazards Arising From the Substance/Mixture No unusual f ire or explosion hazards noted. Special PPE and/or Precautions for Firefighters Wear suitable protective equipment. Page 1 of 4 Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Keep unnecessary personnel away. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Ensure adequate ventilation. Avoid inhalation of dust from the spilled material. Wear appropriate personal protective equipment. Methods and Materials Used for Containment Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. Wash spill site. Cleanup Procedures Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during clean-up. Wash spill site. Section 7: Handling and Storage Precautions for Safe Handling As a general rule, when handling chemicals, avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Clean equipment and work surf aces with suitable detergent or solvent af ter use. Af ter removing gloves, wash hands and other exposed skin thoroughly. Conditions for Safe Storage Store in tight container as def ined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters No biological exposure limits noted f or the ingredient(s). No exposure standards allocated. Appropriate Engineering Controls Airborne exposure should be controlled primarily by engineering controls such as general dilution ventilation, local exhaust ventilation, or process enclosure. Local exhaust ventilation is generally pref erred to general exhaust because it can control the contaminant at its source, preventing dispersion into the work area. An industrial hygiene survey involving air monitoring may be used to determine the ef f ectiveness of engineering controls. Ef f ectiveness of engineering controls intended f or use with highly potent materials should be assessed by use of nontoxic surrogate materials. Handle in accordance with good industrial hygiene and saf ety practice. PPE - Eye/Face Protection Saf ety glasses with sideshields are recommended. Face shields or goggles may be required if splash potential exists or if corrosive materials are present. Approved eye protection (e.g., bearing the ANSI Z87 or CSA stamp) is pref erred. Maintain eyewash f acilities in the work area. PPE - Skin Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. For handling of laboratory scale quantities, a cloth lab coat is recommended. Where signif icant quantities are handled, work clothing may be necessary to prevent take-home contamination. PPE - Body Protection Chemically compatible gloves. For handling solutions, ensure that the glove material is protective against the solvent being used. Use handling practices that minimize direct hand contact. Employees who are sensitive to natural rubber (latex) should use nitrile or other synthetic nonlatex gloves. Use of powdered latex gloves should be avoided due to the risk of latex allergy. For handling of laboratory scale quantities, a cloth lab coat is recommended. Where signif icant quantities are handled, work clothing may be necessary to prevent take-home contamination. PPE - Respiratory Protection Where respirators are deemed necessary to reduce or control occupational exposures, use NIOSH-approved respiratory protection and have an ef f ective respirator program in place (applicable U.S. regulation OSHA 29 CFR 1910.134). Section 9: Physical and Chemical Properties Appearance White powder. Upper/Lower Flammability or Explosive Limits Not available. Odor Not available. Vapor Pressure < 0.0000001 kPa at 25 �C Odor Threshold Not available. Vapor Density Not available. pH Not available. Relative Density Not available. Melting Point/Freezing Point Melting point/freezing point 408.2 - 428 �F (209 - 220 �C) (decomposes) Solubility Freely soluble in hot water. Initial Boiling Point and Boiling Range Not available. Flash Point Not available. Evaporation Rate Not available. Flammability (Solid, Gas) Not applicable. Partition Coefficient 2.8 Auto-Ignition Temperature Not available. Decomposition Temperature Not available. Viscosity Not available. Page 2 of 4 Section 10: Stability and Reactivity Reactivity No reactivity hazards known. Chemical Stability Material is stable under normal conditions. Possibility of Hazardous Reactions No dangerous reaction known under conditions of normal use. Conditions to Avoid None known. Incompatible Materials Strong oxidizing agents. Acids. Metallic salts. Hazardous Decomposition Products Irritating and/or toxic f umes or gases. Emits toxic f umes under f ire conditions Section 11: Toxicological Information Acute Toxicity - LD50 Oral Based on available data, the classif ication criteria are not met. LD50 Mouse Oral 4320 mg/kg Rat 5800 mg/kg Acute Toxicity - Inhalation Based on available data, the classif ication criteria are not met. Acute Toxicity - Dermal Based on available data, the classif ication criteria are not met. Acute Toxicity - Eye Based on available data, the classif ication criteria are not met. Skin Corrosion/Irritation Due to lack of data the classif ication is not possible. Serious Eye Damage/Irritation Due to lack of data the classif ication is not possible. Respiratory or Skin Sensitazation Due to lack of data the classif ication is not possible. Germ Cell Mutagenicity Ames assay of licorice extract (of which glycyrrhizic acid is a component) Result: Negative. Carcinogenicity IARC This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. Carcinogenicity ACGIH This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. Carcinogenicity NTP This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. Carcinogenicity OSHA This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA. Reproductive Toxicity Based on available data, the classif ication criteria are not met. < 2464 mg Reproductivity study Result: Showed no evidence of an increase in birth def ects. >= 500 mg Reproductivity study Result: Showed association between licorice (of which glycyrrhizic acid is a component) consumption and an increased risk of preterm delivery. Specific Target Organ Toxicity - Single Exposure Due to lack of data the classif ication is not possible. Specific Target Organ Toxicity - Repeated Exposure Due to lack of data the classif ication is not possible. Aspiration Hazard Based on available data, the classif ication criteria are not met. Section 12: Ecological Information Toxicity No ecotoxicity data noted f or the ingredient(s). Persistence and Degradability No data is available on the degradability of this product. Bio-accumulative Potential Not available. Mobility in Soil Not available. Other Adverse Effects Not available. Section 13: Disposal Considerations Waste Treatment Methods Product This product, in its present state, when discarded or disposed of , is not a hazardous waste according to Federal regulations (40 CFR 261.4 (b)(4)). Under RCRA, it is the responsibility of the user of the product to determine, at the time of disposal, whether the product meets RCRA criteria f or hazardous waste. Dispose in accordance with all applicable regulations. Waste Treatment Methods Packaging Empty containers or liners may retain some product residues. This material and its container must be disposed of in a saf e manner. Empty containers should be taken to an approved waste handling site f or recycling or disposal. Since emptied containers may retain product residue, f ollow label warnings even af ter container is emptied. Special Precautions Landfill or Incinerations No data available Other Information No data available. Page 3 of 4 Section 14: Transport Information UN Number Not dangerous goods. UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards No data available Section 15: Regulatory Information US f ederal regulations CERCLA/SARA Hazardous Substances - Not applicable. All components are on the U.S. EPA TSCA Inventory List. Superf und Amendments and Reauthorization Act of 1986 (SARA) Hazard categories Immediate Hazard - No Delayed Hazard - No Fire Hazard - No Pressure Hazard - No Reactivity Hazard - No SARA 302 Extremely hazardous substance No SARA 311/312 Hazardous chemical No Other f ederal regulations Saf e Drinking Water Act (SDWA) Not regulated. Food and Drug Administration (FDA) Not regulated. US state regulations This product does not contain a chemical known to the State of Calif ornia to cause cancer, birth def ects or other reproductive harm. International Inventories Country(s) or region Inventory name On inventory (yes/no)* Australia Australian Inventory of Chemical Substances (AICS) Yes Canada Domestic Substances List (DSL) Yes Canada Non-Domestic Substances List (NDSL) No China Inventory of Existing Chemical Substances in China (IECSC) Yes Europe European Inventory of Existing Commercial Chemical Yes Substances (EINECS) Europe European List of Notif ied Chemical Substances (ELINCS) No Japan Inventory of Existing and New Chemical Substances (ENCS) Yes Korea Existing Chemicals List (ECL) Yes New Zealand New Zealand Inventory Yes Philippines Philippine Inventory of Chemicals and Chemical Substances Yes (PICCS) United States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory Yes *A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s) Section 16: Other Information Additional Information Prepared By Lisa Russell Revision Date 01/07/2019 12:12 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
