AVICEL PH105 (MICROCRYSTALLINE CELLULOSE, NF) 500GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name Microcrystalline Cellulose (AVICEL PH101) Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) Microcrystalline cellulose (INCI Name): MCC, cellulose gel Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Not a hazardous substance or mixture. Signal Word None Hazard Statement(s) N/A Pictogram(s) N/A Precautionary Statement(s) N/A Hazards Not Otherwise Classified May f orm combustible dust concentrations in air. Aspiration or inhalation of this product could cause chemical pneumonitis. Excessive inhalation of dust can mechanically impede respiration. Due to the hygroscopic properties of the gums, they can f orm a paste or gel in the airway. Ingredient(s) with Unknown Toxicity No data Available Section 3: Composition/Information on Ingredients Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel� PH101 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. If breathing is dif f icult or if discomf ort occurs and persists, obtain medical attention. In Case of Skin Contact Wash of f with warm water and soap as a precaution In Case of Eye Contact Rinse thoroughly with plenty of water, also under the eyelids. Get medical attention if eye irritation develops or persists. If Swallowed Never give anything by mouth to an unconscious person. Drink plenty of water. Get medical attention if symptoms occur. Most Important Symptoms and Effects Dif f iculty breathing. Cough. Aspiration or inhalation of this product could cause chemical pneumonitis. Treatment is symptomatic and supportive. Section 5: Fire Fighting Measures Suitable Extinguishing Media Use water spray, alcohol-resistant f oam, dry chemical or carbon dioxide. Special Hazards Arising From the Substance/Mixture Avoid dust f ormation Fine dust dispersed in air, in suf f icient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Static electricity might be suf f icient to ignite dust clouds. Possibility of ignition will depend on the minimum ignition energy (MIE) and the type of operations undertaken with the material. MIE values are not provided in this SDS. Special PPE and/or Precautions for Firefighters As in any f ire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and f ull protective gear. Page 1 of 4 Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Avoid dispersal of dust in the air (i.e., cleaning dust surf aces with compressed air.). Avoid breathing dust. Powder may become slippery when wet. For personal protection see section 8. Methods and Materials Used for Containment Dust deposits should not be allowed to accumulate on surf aces, as these may f orm an explosive mixture if they are released into the atmosphere in suf f icient concentration. Sweep, vacuum or shovel into suitable containers f or disposal. Nonsparking tools should be used. Washdown water is not recommended. Powder may become slippery when wet. Cleanup Procedures Sweep, vacuum or shovel into suitable containers f or disposal. Nonsparking tools should be used. Washdown water is not recommended. Powder may become slippery when wet. Section 7: Handling and Storage Precautions for Safe Handling Handle in accordance with good industrial hygiene and saf ety practice. Minimize dust generation and accumulation. Routine housekeeping should be instituted to ensure that dusts do not accumulate on surf aces. Dry powdered material can build static electricity when subjected to the friction of transf er and mixing operations. Provide adequate precautions, such as electrical grounding and bonding, or inert atmosphere. Ensure adequate ventilation. In case of insuf f icient ventilation, wear suitable respiratory equipment if release of airborne dust is expected. Conditions for Safe Storage Store at less than 25 °C, in tightly closed containers. Keep out of direct sunlight. Store in dry environment away from heat and sources of ignition, i.e., steam pipes, radiant heaters, hot air vents or welding sparks. Do not store with strong smelling materials. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Microcrystalline cellulose (9004-34-6) ACGIH TLV TWA: 10 mg/m3 OSHA PEL TWA: 15 mg/m3 TWA: 5 mg/m3 NIOSH TWA: 10 mg/m3 TWA: 5 mg/m3 Mexico Mexico: TWA 10 mg/m3 Mexico: STEL 20 mg/m3 Microcrystalline cellulose (9004- 34-6) British Columbia TWA: 10 mg/m3 TWA: 3 mg/m3 Quebec TWA: 10 mg/m3 TWA: 5 mg/m3 Ontario TWAEV TWA: 10 mg/m3 Alberta TWA: 10 mg/m3 TWA: 5 mg/m3 Appropriate Engineering Controls It is recommended that all dust control equipment such as local exhaust ventilation and material transport systems involved in the handling of this product contain explosion relief vents or an explosion suppression or an oxygendef icient environment. Use only appropriately classif ied electrical equipment and powered industrial trucks. Handle in accordance with good industrial hygiene and saf ety practice. Protective engineering solutions should be implemented and in use. These recommendations apply to the product as supplied. If the product is used in mixtures, contact an appropriate protective equipment supplier or industrial hygienist f or more inf ormation. PPE - Eye/Face Protection Saf ety glasses. PPE - Skin Protection Minimize skin contamination by f ollowing good industrial hygiene practices. Use gloves if extended exposure is anticipated. Protective gloves PPE - Body Protection Minimize skin contamination by f ollowing good industrial hygiene practices. Use gloves if extended exposure is anticipated. Protective gloves PPE - Respiratory Protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required f or high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations Section 9: Physical and Chemical Properties Appearance Dry powder Free f lowing powder Upper/Lower Flammability or Explosive Limits No data available Odor No data available Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH 5.0 - 7.0 ( 11 % solids dispersion) (in solution) Relative Density No data available Melting Point/Freezing Point No data available Solubility Insoluble in water Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient No data available Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Page 2 of 4 Section 10: Stability and Reactivity Reactivity No data available Chemical Stability Stable under recommended storage conditions. Possibility of Hazardous Reactions None under normal processing. Hazardous polymerization does not occur. Conditions to Avoid Dust f ormation. Excessive heat. Humid air. Sparks. Incompatible Materials Oxidizing agents. Strong acids. Hazardous Decomposition Products Burning produces obnoxious and toxic f umes: Sulf ur oxides. Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Oral > 5 g/kg ( Rat ). Acute Toxicity - Inhalation LC50 Inhalation > 5800 mg/m3 ( Rat ) 4 h Acute Toxicity - Dermal LD50 Dermal > 2 g/kg ( Rabbit ) Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation No data available Germ Cell Mutagenicity No known mutagenic or teratogenic ef f ects. Carcinogenicity IARC Contains no ingredient listed as a carcinogen Carcinogenicity ACGIH Contains no ingredient listed as a carcinogen Carcinogenicity NTP Contains no ingredient listed as a carcinogen Carcinogenicity OSHA Contains no ingredient listed as a carcinogen Reproductive Toxicity This product does not contain any known or suspected reproductive hazards. Specific Target Organ Toxicity - Single Exposure None known. Specific Target Organ Toxicity - Repeated Exposure None noted in chronic animal studies. Aspiration Hazard Aspiration may cause chemical pneumonitis. Excessive inhalation of dust can mechanically impede respiration. Section 12: Ecological Information Toxicity The environmental impact of this product has not been f ully investigated. Persistence and Degradability Expected to biodegrade, based on component inf ormation. Bio-accumulative Potential Bioaccumulation is unlikely Mobility in Soil No data available Other Adverse Effects None known. Section 13: Disposal Considerations Waste Treatment Methods Product This material, as supplied, is not a hazardous waste according to Federal regulations (40 CFR 261). This material could become a hazardous waste if it is mixed with or otherwise comes in contact with a hazardous waste, if chemical additions are made to this material, or if the material is processed or otherwise altered. Consult 40 CFR 261 to determine whether the altered material is a hazardous waste. Consult the appropriate state, regional, or local regulations f or additional requirements. Waste Treatment Methods Packaging Dispose of in accordance with f ederal, state and local regulations. Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number Not dangerous goods. UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards N/A Page 3 of 4 Section 15: Regulatory Information U.S. Federal Regulations SARA 313 Section 313 of Title III of the Superf und Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372 SARA 311/312 Hazard Categories Acute health hazard No Chronic health hazard No Fire hazard No Sudden release of pressure hazard No Reactive Hazard No Clean Water Act This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42). CERCLA This material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superf und Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specif ic reporting requirements at the local, regional, or state level pertaining to releases of this material. US State Regulations Calif ornia Proposition 65 This product does not contain any Proposition 65 chemicals. U.S. State Right-to-Know Regulations Chemical name New Jersey X, Massachusetts, X Pennsylvania, X. Microcrystalline cellulose 9004-34-6 International Inventories Chemical name TSCA (United States) X, DSL (Canada)X, EINECS/ELINC S (Europe)X, ENCS (Japan)X, China (IECSC) X, KECL (Korea) X, PICCS (Philippines) X, AICS (Australia) X, Microcrystalline cellulose 9004-34-6 Mexico - Grade Slight risk, Grade 1 Chemical name Carcinogen Status Mexico Microcrystalline cellulose Mexico: TWA 10 mg/m3 Mexico: STEL 20 mg/m3 NFPA Health Hazards 1 Flammability 1 Instability 0 Special Hazards - HMIS Health Hazards 1 Flammability 1 Physical hazard 0 Personal Protection X Section 16: Other Information Additional Information N/A Prepared By Scarlotte Smith Revision Date 01/24/2019 11:51 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
