Vanguard Plus CPV 50 x1-Dose
Parvovirus Vaccine, Modified Live Virus, dogs 6 weeks or older. Preservatives: Gentamicin and amphotericin B.
VANGUARD� PLUS CPV
Zoetis
Parvovirus Vaccine
Modified Live Virus
For use in dogs only
PRODUCT DESCRIPTION: Vanguard Plus CPV is for vaccination of healthy dogs 6 weeks of age or older for the prevention of canine parvoviral enteritis caused by canine parvovirus (CPV). Vanguard Plus CPV contains a strain of CPV attenuated by low passage on an established canine cell line. The vaccine is high titer (>107.0 TCID50/dose) and was attenuated by low passage (35 passes from the canine isolate with a maximum of 2 additional passes allowed for production) on the canine cell line which gives it the immunogenic properties capable of overriding maternal antibody interference at the levels indicated below. Some puppies in the field may have higher levels of maternal antibodies than those evaluated in our pivotal efficacy study. Vanguard Plus CPV is packaged in liquid form.
SAFETY AND EFFICACY: Vanguard Plus CPV was subjected to comprehensive safety and efficacy testing at Zoetis Inc. Extensive field safety trials conducted by Zoetis Inc. showed it to be safe and reaction-free in dogs as young as 6 weeks of age under normal usage conditions.
Product safety was further demonstrated by a backpassage study which included oral administration of multiple doses of the vaccine strain to susceptible dogs, all of whom remained normal. Vanguard Plus CPV vaccine virus shares a characteristic with other live CPV vaccine strains in that the vaccine virus may be present in the feces following administration. Although this CPV vaccine virus was found occasionally and in low titers in the feces of vaccinated dogs, testing demonstrated that the vaccine master seed did not revert to virulence following 6 consecutive backpassages in susceptible dogs.
DIRECTIONS:
1. General Directions: Vaccination of healthy dogs is recommended. Shake well. Aseptically administer 1 mL subcutaneously or intramuscularly.
2. Primary Vaccination: Healthy dogs 6 weeks of age or older should receive 3 doses, each administered 3 weeks apart.
3. Revaccination: Annual revaccination with a single dose is recommended, although, as recommended by the American Veterinary Medical Association and its Council on Biologic and Therapeutic Agents, the attending veterinarian should determine the frequency of revaccination based on the animal's lifestyle and risk of exposure.6
PRECAUTIONS:
1. Store at 2�-7�C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.
2. Use entire contents when first opened.
3. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.
4. Burn containers and all unused contents.
5. Contains gentamicin and amphotericin B as preservatives.
6. Vaccination of pregnant bitches should be avoided.
7. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.
8. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.
