Pfizer Animal Health
(Ceftiofur Crystalline Free Acid)
Sterile Suspension
Equivalent to 100 mg per mL ceftiofur
For intramuscular administration in the post-auricular region of the neck of swine.
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
DESCRIPTION
EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is a ready-to-use formulation that contains the crystalline free acid of ceftiofur, which is a broad spectrum cephalosporin antibiotic active against gram-positive and gram-negative bacteria including ß-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal in vitro, resulting from inhibition of cell wall synthesis.
Each mL of this ready-to-use sterile suspension contains ceftiofur crystalline free acid equivalent to 100 mg ceftiofur, in a Miglyol® and cottonseed oil based suspension.
Figure 1. Structure of ceftiofur crystalline free acid:
Chemical name of ceftiofur crystalline free acid:
INDICATIONS
EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is indicated for the treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, and Streptococcus suis.
DOSAGE
Administer by intramuscular (IM) injection in the post-auricular region of the neck as a single dosage of 2.27 mg ceftiofur equivalents (CE)/lb (5.0 mg CE/kg) body weight (BW). This is equivalent to 1 mL sterile suspension per 44 lb (20 kg) BW. No more than 2 mL should be injected in a single injection site. Injection volumes in excess of 2 mL may result in violative residues. Pigs heavier than 88 lb (40 kg) will require more than one injection.
Most animals will respond to treatment within three to five days. If no improvement is observed, the diagnosis should be reevaluated.
ADMINISTRATION
Shake well before using. EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is to be administered by intramuscular injection in the post-auricular region of the neck.
WARNINGS
FOR USE IN ANIMALS ONLY. NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN.
Restricted Drug (California) - Use Only as Directed
STORAGE CONDITIONS
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Shake well before using. Contents should be used within 12 weeks after the first dose is removed.
HOW SUPPLIED
EXCEDE FOR SWINE Sterile Suspension 100 mg/mL is available in the following package size:
