CattleMaster Gold FP 5
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine, Modified Live and Killed Virus, cattle (including pregnant cows). Preservative: Gentamicin. Meat withdrawal: 21 days.
CattleMaster� GOLD FP� 5
Zoetis
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine
Modified Live and Killed Virus
PRODUCT DESCRIPTION: CattleMaster GOLD FP 5 is for vaccination of healthy cattle, including pregnant cows, as an aid in preventing abortion caused by infectious bovine rhinotracheitis (IBR, bovine herpesvirus Type 1), persistently infected calves caused by bovine virus diarrhea (BVD) virus Types 1 and 2, and respiratory disease caused by IBR, BVD (Types 1 and 2), parainfluenza3 (PI3), and bovine respiratory syncytial virus (BRSV). CattleMaster GOLD FP 5 is a freeze-dried preparation of chemically altered strains of IBR and PI3 viruses and modified live BRSV, plus a liquid, adjuvanted preparation of inactivated BVD virus (Types 1 and 2). The liquid component is used to rehydrate the freeze-dried component. Viral antigens are propagated on an established cell line. This product contains a unique combination of adjuvants, including Amphigen�, to enhance the immune response to its fractions. The BVD diluent of CattleMaster GOLD FP 5 is further processed by a proprietary system to help assure consistency of the formulation.
DISEASE DESCRIPTION: IBR and BVD are commonly associated with reproductive and respiratory disease while BRSV and PI3 are predominantly associated with respiratory disease. IBR virus infection is characterized by high temperature, excessive nasal discharge, conjunctivitis and ocular discharge, inflamed nose ("red nose"), increased rate of respiration, coughing, loss of appetite, and depression. Cattle infected during pregnancy may abort. A characteristic of IBR virus is that it establishes a latent infection in sensory neurons, typically trigeminal ganglia or iliosacral dorsal root ganglia.1 From these sites of latency, it can be reactivated when an infected animal is stressed or injured. Subsequently, the virus is shed and transmitted by contact to other cattle.
BVD virus may be transmitted in nasal secretions, saliva, blood, feces, and/or urine, and by direct contact with contaminated objects; it invades through the nose and mouth and replicates systemically. Infection during pregnancy may result in abortion, fetal resorption, or congenital malformation of the fetus. Moreover, if susceptible cows are infected with noncytopathic BVD virus during the first trimester of pregnancy, their calves may be born persistently infected with the virus. Exposure of those calves to certain virulent BVD virus strains may precipitate BVD-mucosal disease. Both BVD Types 1 and 2 can show a variety of clinical signs. The signs may be mild and not readily apparent. Clinical signs may include severe immune suppression, diarrhea, anorexia, depression, fever and respiratory disease. If infected with some Type 2 strains of BVD, severe thrombocytopenia may occur and hemorrhaging may be seen.
PI3 virus usually localizes in the upper respiratory tract, causing elevated temperature and moderate nasal and ocular discharge. Although clinical signs typically are mild, PI3 infection weakens respiratory tissues. Invasion and replication of other pathogens, particularly Pasteurella spp., is thereby facilitated and may result in pneumonia.
BRSV is the etiologic agent of a specific viral respiratory disease of cattle of all ages, including nursing calves. Infection is characterized by rapid breathing, coughing, loss of appetite, discharge from the nose and eyes, fever, and swelling around the throat and neck. In an acute outbreak, deaths may follow within 48 hours after onset of signs. Clinically, BRSV infection may be indistinguishable from other viral infections associated with the bovine respiratory disease complex. BRSV infection, like PI3, facilitates invasion and replication of other respiratory pathogens. Exacerbation of clinical signs has been documented when concurrent BRSV and BVD or IBR infection exists.
DIRECTIONS:
1. General Directions: Vaccination of healthy cattle, including pregnant cows, is recommended. Aseptically rehydrate the freeze-dried vaccine with the liquid vaccine provided, shake well, and administer 2 mL subcutaneously.
2. Primary Vaccination: Healthy cattle should receive an initial 2 doses 3 weeks apart. As an aid in preventing IBR-induced abortion and BVD persistently infected calves, administer a 2-mL dose at approximately 5 and 2 weeks prior to breeding. Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.
3. Revaccination: Annual revaccination with a single dose is recommended.
4. Good animal husbandry and herd health management practices should be employed.
PRECAUTIONS:
1. Store at 2�-7�C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.
2. Use entire contents when first opened.
3. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.
4. Transient local reactions may be observed at the injection site.
5. Burn containers and all unused contents.
6. Do not vaccinate within 21 days before slaughter.
7. Contains gentamicin as preservative.
8. Routine handling of lactating dairy cattle, including administration of vaccines such as CattleMaster GOLD FP 5, has been associated with transient reduction of milk production.
9. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.
10. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are persistently infected with BVD virus or incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.
