RX ITEM-Zemuron 10Mg/Ml Vial 10X10Ml By Merck

ZEMURON- rocuronium bromide injection, solution
Organon Pharmaceuticals USA


INDICATIONS AND USAGE
ZEMURON� (rocuronium bromide) Injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
2 DOSAGE AND ADMINISTRATION
ZEMURON is for intravenous use only. This drug should only be administered by experienced clinicians or trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents. Doses of ZEMURON injection should be individualized and a peripheral nerve stimulator should be used to monitor drug effect, need for additional doses, adequacy of spontaneous recovery or antagonism, and to decrease the complications of overdosage if additional doses are administered.
The dosage information which follows is derived from studies based upon units of drug per unit of body weight. It is intended to serve as an initial guide to clinicians familiar with other neuromuscular blocking agents to acquire experience with ZEMURON.
In patients in whom potentiation of, or resistance to, neuromuscular block is anticipated, a dose adjustment should be considered
DOSAGE FORMS AND STRENGTHS
ZEMURON (rocuronium bromide) injection is available as
5 mL multiple dose vials containing 50 mg rocuronium bromide injection (10 mg/mL)
DESCRIPTION
ZEMURON (rocuronium bromide) injection is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. Rocuronium bromide is chemically designated as 1-[17β-(acetyloxy)-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-propenyl)pyrrolidinium bromide.
CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
ZEMURON is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.

RX ITEM-Zemuron 10Mg/Ml Vial 10X10Ml By
NDC 00052-0450-16 UPC/GTIN No.3-00520-45016-4 Mfg.Part No.45016

Zemuron 10Mg/Ml Vial 10X10Ml By Merck
BRAND: ZEMURON NDC: 00052-0450-16,52045016 UPC: 3-00520-45016-4,300520450164

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