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RX ITEM-Lopressor 100Mg Tab 100 By Validus Pharma

NDC 30698-0459-01 UPC/GTIN No.3-30698-45901-0 Mfg.Part No.45901BRAND: LOPRESSOR NDC: 30698-0459-01,30698045901 UPC: 3-30698-45901-0,330698459010 Validus Pharmaceuticals Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Lopressor 100Mg Tab 100 By Validus Pharma

$452.15$399.00

item No.:RX365247 NDC No.30698045901 UPC No.:330698459010 NDC No. 30698-0459-01 UPC/GTIN No. 3-30698-45901-0 MPN 45901 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx365247 Lopressor 100mg Tab 100 by Validus Pharma. Item No. 3365247 NDC No. 30698045901 UPC No. 330698459010 Other Name Lopressor,

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LOPRESSOR- metoprolol tartrate injection, solution
Novartis Pharmaceuticals Corporation

Lopressor�

metoprolol tartrate injection, USP

Rx only

Prescribing Information

DESCRIPTION

Lopressor, metoprolol tartrate USP, is a selective beta1 -adrenoreceptor blocking agent, available in 5-mL ampuls for intravenous administration. Each ampul contains a sterile solution of metoprolol tartrate USP, 5 mg, and sodium chloride USP, 45 mg, and water for injection USP. Metoprolol tartrate USP is (�)-1-(Isopropylamino)-3-[p -(2-methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate (2:1) salt
Metoprolol tartrate USP is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very soluble in water; freely soluble in methylene chloride, in chloroform, and in alcohol; slightly soluble in acetone; and insoluble in ether.

CLINICAL PHARMACOLOGY

Mechanism of Action
Lopressor is a beta1 -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, Lopressor also inhibits beta2 -adrenoreceptors, chiefly located in the bronchial and vascular musculature.

Clinical pharmacology studies have demonstrated the beta-blocking activity of metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia.

Hypertension

The mechanism of the antihypertensive effects of beta-blocking agents has not been fully elucidated. However, several possible mechanisms have been proposed: (1) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic neuron sites, leading to decreased cardiac output; (2) a central effect leading to reduced sympathetic outflow to the periphery; and (3) suppression of renin activity.

Angina Pectoris

By blocking catecholamine-induced increases in heart rate, in velocity and extent of myocardial contraction, and in blood pressure, Lopressor reduces the oxygen requirements of the heart at any given level of effort, thus making it useful in the long-term management of angina pectoris.

Myocardial Infarction

The precise mechanism of action of Lopressor in patients with suspected or definite myocardial infarction is not known.
DOSAGE AND ADMINISTRATION

Myocardial Infarction
Early Treatment: During the early phase of definite or suspected acute myocardial infarction, initiate treatment with Lopressor as soon as possible after the patient's arrival in the hospital. Such treatment should be initiated in a coronary care or similar unit immediately after the patient's hemodynamic condition has stabilized.

Begin treatment in this early phase with the intravenous administration of three bolus injections of 5 mg of Lopressor each; give the injections at approximately 2-minute intervals. During the intravenous administration of Lopressor, monitor blood pressure, heart rate, and electrocardiogram.

In patients who tolerate the full intravenous dose (15 mg), initiate Lopressor tablets, 50 mg every 6 hours, 15 minutes after the last intravenous dose and continue for 48 hours. Thereafter, the maintenance dosage is 100 mg orally twice daily.

Start patients who appear not to tolerate the full intravenous dose on Lopressor tablets either 25 mg or 50 mg every 6 hours (depending on the degree of intolerance) 15 minutes after the last intravenous dose or as soon as their clinical condition allows. In patients with severe intolerance, discontinue Lopressor (see WARNINGS).

NDC 30698-0459-01 UPC/GTIN No.3-30698-45901-0 Mfg.Part No.45901
RX ITEM-Lopressor 100Mg Tab 100 By Valid
NDC 30698-0459-01 UPC/GTIN No.3-30698-45901-0 Mfg.Part No.45901

BRAND: LOPRESSOR NDC: 30698-0459-01,30698045901 UPC: 3-30698-45901-0,330698459010 Validus Pharmaceuticals
Lopressor 100Mg Tab 100 By Validus Pharm
BRAND: LOPRESSOR NDC: 30698-0459-01,30698045901 UPC: 3-30698-45901-0,330698459010 Validus Pharmaceuticals

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
METOPROLOL TARTRATE ORAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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