Rx Item-Emend Trifold 125Mg/80Mg Kit 3 By Merck

EMEND - aprepitant capsule
EMEND - aprepitant
Physicians Total Care, Inc.

1 INDICATIONS AND USAGE

1.1 Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)
EMEND, in combination with other antiemetic agents, is indicated for the:

prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin
prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC) [see Dosage and Administration (2.1)].
1.2 Prevention of Postoperative Nausea and Vomiting (PONV)


EMEND is indicated for the prevention of postoperative nausea and vomiting [see Dosage and Administration (2.2)].

1.3 Limitations of Use
EMEND has not been studied for the treatment of established nausea and vomiting.

Chronic continuous administration is not recommended [see Warnings and Precautions (5.5)].

2 DOSAGE AND ADMINISTRATION

2.1 Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)
Capsules of EMEND (aprepitant) are given for 3 days as part of a regimen that includes a corticosteroid and a 5-HT3 antagonist. The recommended dose of EMEND is 125 mg orally 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.

EMEND may be taken with or without food.

EMEND (fosaprepitant dimeglumine) for Injection (115 mg) is a prodrug of aprepitant and may be substituted for oral EMEND (125 mg), 30 minutes prior to chemotherapy, on Day 1 only of the CINV regimen as an intravenous infusion administered over 15 minutes.

In clinical studies with EMEND, the following regimen was used for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy:

RX ITEM-Emend Trifold 125Mg/80Mg Kit 3 B
NDC 00006-3862-03 UPC/GTIN No.3-00063-86203-5 Mfg.Part No.386203 BRAND: EMEND NDC: 00006-3862-03,6386203 UPC: 3-00063-86203-5,300063862035 Merck & Co.

Emend Trifold 125Mg/80Mg Kit 3 By Merck
BRAND: EMEND NDC: 00006-3862-03,6386203 UPC: 3-00063-86203-5,300063862035 Merck & Co.

APREPITANT ORAL CAP DS PK
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