Rx Item-Coly-Mycin M 150Mg Vial 6X10Ml By JHP Pharma

COLY-MYCIN M- colistimethate sodium injection
JHP Pharmaceuticals LLC

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Coly-Mycin M and other antibacterial drugs, Coly-Mycin M should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

FOR INTRAMUSCULAR AND INTRAVENOUS USE

DESCRIPTION

Coly-Mycin� M Parenteral (Colistimethate for Injection, USP) is a sterile parenteral antibiotic product which, when reconstituted (see Reconstitution), is suitable for intramuscular or intravenous administration.



Each vial contains colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity).

Colistimethate sodium is a polypeptide antibiotic with an approximate molecular weight of 1750. The empirical formula is C58 H105 N16 Na5 O28 S5 and the structural formula is represented below:

Chemical Structure
(click image for full-size original)
CLINICAL PHARMACOLOGY

Typical serum and urine levels following a single 150 mg dose of Coly-Mycin M Parenteral IM or IV in normal adult subjects are shown in Figure 1.

Figure
(click image for full-size original)
Higher serum levels were obtained at 10 minutes following IV administration. Serum concentration declined with a half-life of 2�3 hours following either intravenous or intramuscular administration in adults and in the pediatric population, including premature infants.

Average urine levels ranged from about 270 mcg/mL at 2 hours to about 15 mcg/mL at 8 hours after intravenous administration and from 200 to about 25 mcg/mL during a similar period following intramuscular administration.

Microbiology
Colistimethate sodium is a surface active agent which penetrates into and disrupts the bacterial cell membrane. It has been shown to have bactericidal activity against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section:

RX ITEM-Coly-Mycin M 150Mg Vial 6X10Ml B
Item No.:RX118606 118606 NDC No.42023010706 42023-107-06 4202310706 UPC No.:342023107063 342023-107063 NDC No. 42023-0107-06 UPC/GTIN No. 3-42023-10706-3

Coly-Mycin M 150Mg Vial 6X10Ml By JHP Ph
Item No.:RX118606 118606 NDC No.42023010706 42023-107-06 4202310706 UPC No.:342023107063 342023-107063 NDC No. 42023-0107-06 UPC/GTIN No. 3-42023-10706-3

COLISTIN (COLISTIMETHATE
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

DOWNLOAD DRUG INFO
DOWNLOAD DRUG INFO