CAS No. 97540-22-2
PROPERTY Light Sensitive | Hygroscopic | Refrigerated
Clinical Information
Gen. Code and Des.
74487 s-adenosylmethionine sul tosyl MISCELL POWDER 100 %
Strength
100 %
Dose Form
POWDER (GRAM)
Product Category
RX Pharmaceuticals
Fine Line Class
850085008510 All Rx Products
DEA Class
NC
OMP Family
AHFS Class
96000000 PHARMACEUTICAL AIDS
Active Ingredients
7165 s-adenosylmethionine sulfate tosylate 97540222
PRODUCT NAME ADEMETIONINE DISULFATE TOSYLATE (SAMe)
PRODUCT CODE 2904
SUPPLIER MEDISCA Inc.
661 Route 3, Unit C, Plattsburgh, NY, 12901
3955 W. Mesa Vista Ave., Unit A-10, Las Vegas, NV, 89118
6641 N. Belt Line Road, Suite 130, Irving, TX, 75063
MEDISCA Pharmaceutique Inc.
4509 Rue Dobrin, St. Laurent, QC, H4R 2L8
21300 Gordon Way, Unit 153/158, Richmond, BC V6W 1M2
MEDISCA Australia PTY LTD
Tel.: 1.300.786.392 | Fax.: 61.2.9700.9047
Unit 7, Heritage Business Park
5-9 Ricketty Street, Mascot, NSW 2020
CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300
NSW Poisons Information Centre: 131 126
EMERGENCY PHONE
USES Supplement
SECTION 2: HAZARDS IDENTIFICATION
Acute Toxicity - Oral (Category 5)
Eye Damage (Category 1)
GHS CLASSIFICATION
PICTOGRAM
SIGNAL WORD Danger
May be harmful if swallowed
Causes severe eye damage
May cause severe skin burns.
HAZARD STATEMENT(S)
AUSTRALIA-ONLY HAZARDS Not Applicable.
Do not breathe dust or mist.
Wash thoroughly after handling.
Wear protective gloves, protective clothing, eye protection and face protection.
PRECAUTIONARY STATEMENT(S) Prevention
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF ON SKIN (OR HAIR): Take off immediately all contaminated clothing. Rinse skin with
water/shower. Wash contaminated clothing before reuse.
IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately
call a poison center or medical professional.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
Response
Storage Store locked up.
Disposal Dispose of contents and/or container in accordance with local regulations.
HMIS CLASSIFICATION Health Hazard 3 Flammability 1
Reactivity 0 Personal Protection E
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SAFETY DATA SHEET
SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
CHEMICAL NAME S-Adenosyl-L-methionine disulfate tosylate
BOTANICAL NAME Not applicable
SYNONYM Ademetionine disulfate p-toluensulfonate; S-adenosyl-L-methionine-p-toluenesulfonate disulfate
CHEMICAL FORMULA C₂₂H₃₄N₆O₁₆S₄
CAS NUMBER 97540-22-2
ALTERNATE CAS NUMBER 29908-08-0
MOLECULAR WEIGHT 766.80
CHEMICAL NAME CAS NUMBER % BY WEIGHT
ADEMETIONINE DISULFATE 97540-22-2 100
TOSYLATE
COMPOSITION
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as health hazards and hence require reporting in this section.
SECTION 4: FIRST-AID MEASURES
Flush with copious amounts of water for 15 minutes, separating eyelids with fingers. If irritation persists seek
medical aid.
IN CASE OF EYE CONTACT
IN CASE OF SKIN CONTACT Wash with soap & water for 15 minutes. If irritation persists seek medical aid.
IF SWALLOWED Call a physician. Wash out mouth with water. Do not induce vomiting without medical advice.
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a
physician
IF INHALED
SYMPTOMS AND EFFECTS Not expected to present a significant hazard under anticipated conditions of normal use.
SECTION 5: FIREFIGHTING MEASURES
SPECIFIC HAZARDS ARISING FROM Corrosive to the eyes and respiratory tract.
THE CHEMICAL
FLAMMABLE PROPERTIES May be combustible at high temperature
HAZARDOUS COMBUSTION PRODUCTS Under fire conditions, hazardous fumes will be present.
Small fire: dry chemical, CO₂ or water spray. Large fire: dry chemical, CO₂, alcohol resistant foam or water
spray. Do not get water inside containers.
EXTINGUISHING MEDIA
PROTECTIVE EQUIPMENT AND Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
PRECAUTIONS FOR FIREFIGHTERS
SECTION 6: ACCIDENTAL RELEASE MEASURES
Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
PERSONAL PRECAUTIONS
METHODS & MATERIAL FOR On land, sweep or shovel into suitable containers. Minimize generation of dust.
CONTAINMENT
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SAFETY DATA SHEET
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Wear
respirator, chemical safety goggles, rubber boots and heavy rubber gloves. Stop leak if you can do it without
risk. Prevent entry into waterways, sewers, basements or confined areas. Shut off all sources of ignition.
Evacuate the area. If necessary, employ water fog to disperse the vapors. Absorb the matter with compatible
vermiculite or other absorbing material. Place in a suitable container and retain for disposal. Ventilate and clean
the affected area. Do not flush into sewerage system or to drains.
CLEANUP PROCEDURE
SECTION 7: HANDLING AND STORAGE
Do not inhale. Avoid contact with eyes, skin and clothing. Avoid prolonged or repeated exposure. Wash
thoroughly after handling. Store away from incompatible materials, in a well-ventilated area. Eliminate all
sources of ignition. Store in accordance with local regulations. Do not store in unlabelled containers.
Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Use
appropriate containment to avoid environmental contamination.
PRECAUTIONS FOR SAFE HANDLING
Store in original container, tightly sealed, protected from direct sunlight and moisture.
Preserve in tight, light resistant containers at a temperature of 2-8°C
STORAGE CONDITIONS
SECTION 8: EXPOSURE CONTROLS/ PERSONAL PROTECTION
Chemical Name: ADEMETIONINE DISULFATE TOSYLATE CAS #: 97540-22-2
TWA Ceiling STEL REL IDLH Remarks
OSHA PEL N/L N/L - - - -
ACGIH TLV N/L N/L N/L - - -
NIOSH N/L N/L N/L N/L N/L -
AIHA WEEL N/L N/L N/L - - -
Safe Work Australia HSIS N/L N/L N/L - - -
HSE N/L N/L N/L - - -
N/L = Not Listed
Consult local authorities for provincial or state exposure limits. Particulates not otherwise regulated, respirable
fraction: 5 mg/m³
EXPOSURE GUIDELINES
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by WHMIS or OSHA's
eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate
gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators: Follow WHMIS or OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are
exceeded or if irritation or other symptoms are experienced.
PERSONAL PROTECTIVE EQUIPMENT
SPECIFIC ENGINEERING CONTROLS Adequate mechanical ventilation. Fumehood, eye wash station, and safety shower.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE Solid
DESCRIPTION White to off-white hygroscopic powder.
SOLUBILITY Freely soluble in water, practically insoluble in hexane and acetone.
ODOR Odorless
FLAMMABILITY May be combustible at high temperature
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SAFETY DATA SHEET
ODOR THRESHOLD Not available pH 0.9 - 1.5 (5%) MELTING POINT Not available
Not available (115 - 120)°C,
(239-248)°F
BOILING POINT FREEZING POINT Not available FLASH POINT
SPECIFIC GRAVITY 0.250 EVAPORATION RATE Not available EXPLOSIVE LIMIT Not available
UPPER FLAMMABLE/ Not available Not available Not available
EXPLOSIVE LIMIT(S)
LOWER FLAMMABLE/
EXPLOSIVE LIMIT(S)
VAPOR PRESSURE
VAPOR DENSITY Not available Not available -2.270
(AIR = 1)
RELATIVE DENSITY
(WATER = 1)
log P
(OCTANOL-WATER)
Not available DECOMPOSITION Not available Not available
TEMPERATURE
AUTO-IGNITION VISCOSITY
TEMPERATURE
NOTES The physical data presented above are typical values and should not be construed as a specification.
SECTION 10: STABILITY AND REACTIVITY
REACTIVITY Not established
STABILITY Stable under recommended storage conditions
MATERIALS TO AVOID Bases. Reducing agents. Strong oxidizers.
HAZARDOUS DECOMPOSITION Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and other gases may occur
PRODUCTS
HAZARDOUS POLYMERIZATION Will not occur
POSSIBLITY OF HAZARDOUS Not established
REACTION
CONDITIONS TO AVOID Moisture, sunlight and extreme temperatures
SECTION 11: TOXICOLOGICAL INFORMATION
Oral: Rat: LD50: (mg/kg): 3320
Dermal: Rabbit LD50: (mg/kg): Not available
Inhalation: Rat: LC50: (mg/L/4hr): Not available
ACUTE TOXICITY
SKIN CORROSION/IRRITATION May be corrosive to skin (pH: 0.9 - 1.5)
SERIOUS EYE DAMAGE/EYE Causes severe eye damage (pH: 0.9 - 1.5)
IRRITATION
RESPIRATORY OR SKIN Due to lack of data the classification is not possible.
SENSITIZATION
GERM CELL MUTAGENICITY Due to lack of data the classification is not possible.
CARCINOGENICITY OSHA ADEMETIONINE DISULFATE TOSYLATE is not listed.
NTP ADEMETIONINE DISULFATE TOSYLATE is not listed.
IARC ADEMETIONINE DISULFATE TOSYLATE is not evaluated.
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SAFETY DATA SHEET
This product does not contain any chemicals known to the State of California to cause
cancer, birth defects, or any other reproductive harm.
California
Proposition 65
ADDITIONAL CARCINOGENICITY
INFORMATION
Due to lack of data the classification is not possible.
Based on available data, the classification criteria are not met.
Tests on rats and rabbits did not show adverse effects on fertility, reproductive performance or fetal
development. Ademetionine has been used therapeutically in pregnant women.
REPRODUCTIVE TOXICITY
SPECIFIC TARGET ORGAN TOXICITY - Due to lack of data the classification is not possible.
SINGLE EXPOSURE
SPECIFIC TARGET ORGAN TOXICITY - Due to lack of data the classification is not possible.
REPEATED EXPOSURE
ASPIRATION HAZARDS Based on available data, the classification criteria are not met.
Symptoms related to the physical, chemical, and toxicological characteristics:
Headache. Frequent urination. Gastrointestinal disturbances. Mood changes.
SIGNS AND SYMPTOMS OF
EXPOSURE
POTENTIAL HEALTH EFFECTS Inhalation May be harmful if inhaled. Corrisive to the respiratory tract.
Ingestion Harmful if swallowed.
Skin May be harmful if absorbed through skin. May be corrosive to skin.
Eyes Causes severe eye damage.
SECTION 12: ECOLOGICAL INFORMATION
EC50: 48 Hr: Crustacea: (mg/L): Not available
LC50: 96 Hr: Fish: (mg/L): Not available
EC50: 72 or 96 Hr: Algae (or other aqua plants): (mg/L): Not available
TOXICITY
PERSISTENCE AND DEGRADABILITY Not available
BIOACCUMULATIVE POTENTIAL Moderate; Log Pow: -2.270.
MOBILITY IN SOIL Freely soluble in water
OTHER ADVERSE EFFECTS Not available
This product is not intended to be released into the environment
SECTION 13: DISPOSAL CONSIDERATIONS
WASTE DISPOSAL Dispose of in accordance with federal / local laws and regulations. Avoid release into the environment.
SECTION 14: TRANSPORT INFORMATION
UNITED STATES & CANADA
UN PROPER SHIPPING NAME Not dangerous good
UN NUMBER Not applicable
CLASS Not applicable
PACKING GROUP Not applicable
AUSTRALIA
UN PROPER SHIPPING NAME Not dangerous good
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SAFETY DATA SHEET
UN NUMBER Not applicable
CLASS Not applicable
PACKING GROUP Not applicable
HAZCHEM Not applicable
ENVIRONMENTAL HAZARDS Not available
SPECIAL SHIPPING INFORMATION Not applicable
SECTION 15: REGULATORY INFORMATION
CERCLA
40 CFR
Part 302.4
SARA (Title III)
40 CFR
Part 372.65
California
New Jersey Massachusetts Prop 65
Right-to-know
Pennsylvania
EPA 40 CFR Part 355
Appendix A Appendix B
Chemical Name
& CAS
ADEMETIONINE DISULFATE N/L N/L N/L N/L N/L N/L N/L N/L
TOSYLATE 97540-22-2
N/L = Not Listed; X = Listed
AUSTRALIAN REGULATIONS
Poisons and Therapeutic
Goods Regulation
Therapeutic Goods
Act
Chemical Name
& CAS
Code of Practices -
Illicit Drug
Precursors
ADEMETIONINE DISULFATE
TOSYLATE 97540-22-2
N/L N/L N/L
SECTION 16: OTHER INFORMATION
REFERENCES Available upon request
CAS �" Chemical Abstract Service; GHS �" Global Harmonized System; OSHA PEL �" Occupational Safety &
Health Administration Permissible Exposure Limits; TWA �" Time Weighted Average; HSIS �" Hazardous
Substances Information System; STEL �" Short Term Exposure Limit; AIHA WEEL �" American Industrial
Hygiene Association Workplace Environment Exposure Levels; LD50 �" Lethal Dose, 50%; IARC �" International
Agency for Research on Cancer; NTP �" National Toxicology Program; WHMIS �" Workplace Hazardous
Materials Information System; SARA �" Superfund Amendments and Reauthorization Act; EPA �" Environmental
Protection Agency; CERCLA �" Comprehensive Environmental Response, Compensation, and Liability Act;
HMIS �" Hazardous Materials Information System; NIOSH �" National Institute for Occupational Safety and
Health; MSHA - Mine Safety and Health Administration; ACGIH - American Conference of Governmental
Industrial Hygienists; IDHL - Immediately Dangerous to Health or Life; TLV �" Threshold Limit Value; HSE �"
Health and Safety Executive; REL - Recommended Exposure Limit
ABBREVIATIONS AND ACRONYMS
LAST REVISION 09/2018
SUPERSEDES 07/2015
This document was created in accordance with OSHA, Safe Work Australia and WHMIS regulations. The above
information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide.
The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of
the product. MEDISCA® shall not be held liable for any damage resulting from handling or from contact with the
above product. Recipients of the product must take responsibility for observing existing laws and regulations.
DISCLAIMER
Last Revision: 09/2
