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Cordran Tape 80x3 inch by Aqua Pharma

NDC 52544-0044-24 UPC/GTIN No.3-52544-04424-9 Mfg.Part No.4424Actavis PharmaThis Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).Actavis PharmaImage 4 of Cordran Tape 80x3 inch by Aqua Pharma

Cordran Tape 80x3 inch by Aqua Pharma

$816.46$710.99

Cordran Tape 80x3 inch by Aqua Pharma
NDC No. NEW 00023-5870-80 0023-5870-80 0023587080 00023587080 OLD 52544-0044-24 UPC/GTIN No. NEW 3-00235-87080-6 300235-870806 300235870806 OLD 3-52544-04424-9 MPN 7080 Only Physician,Pharmacy or Licensed Facility can order this Rx Item No. Rx030569 Cordran 4Mcg/Sq Cm Tpe by Actavis Pharma(TEVA) /Oclassen Ph Item No. 3030569 NDC No. 52544004424 UPC No. 352544044249 Other Name Flurandrenolide,Cordran Therapeutic Code 840600 Therapeutic Class Anti-Inflamma

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CORDRAN- flurandrenolide tape
Watson Pharma, Inc.

DESCRIPTION

Cordran Tape (Flurandrenolide Tape, USP) is a transparent, inconspicuous, plastic surgical tape, impervious to moisture. It contains Cordran (Flurandrenolide, USP), a potent corticosteroid for topical use. Flurandrenolide occurs as white to off-white, fluffy crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One g dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52.

The chemical name of flurandrenolide is Pregn-4-ene-3,20-dione, 6-fluoro-11,21 dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6?, 11�, 16?)-; its empirical formula is C24 H33 FO6 . The structural formula is as follows:

Cordran structural formula.
(click image for full-size original)


Each square centimeter contains 4 ?g (0.00916 ?mol) flurandrenolide uniformly distributed in the adhesive layer. The tape is made of a thin, matte-finish polyethylene film that is slightly elastic and highly flexible.

The adhesive is a synthetic copolymer of acrylate ester and acrylic acid that is free from substances of plant origin. The pressure-sensitive adhesive surface is covered with a protective paper liner to permit handling and trimming before application.

CLINICAL PHARMACOLOGY

Cordran is primarily effective because of its anti-inflammatory, antipruritic, and vasoconstrictive actions.

The mechanism of the anti-inflammatory effect of topical corticosteroids is not completely understood. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. Corticosteroids with anti-inflammatory activity may stabilize cellular and lysosomal membranes. There is also the suggestion that the effect on the membranes of lysosomes prevents the release of proteolytic enzymes and, thus, plays a part in reducing inflammation.

The tape serves as both a vehicle and an occlusive dressing. Retention of insensible perspiration by the tape results in hydration of the stratum corneum and improved diffusion of the medication. The skin is protected from scratching, rubbing, desiccation, and chemical irritation. The tape acts as a mechanical splint to fissured skin. Since it prevents removal of the medication by washing or the rubbing action of clothing, the tape formulation provides a sustained action.

Pharmacokinetics -The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION).

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to those of systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. They are metabolized primarily in the liver and then excreted in the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

INDICATIONS AND USAGE

For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dry, scaling localized lesions.

NDC 52544-0044-24 UPC/GTIN No.3-52544-04424-9 Mfg.Part No.4424
Cordran 4Mcg Sq Cm Tpe by Actavis Pharma
NDC 52544-0044-24 UPC/GTIN No.3-52544-04424-9 Mfg.Part No.4424

Actavis Pharma

Actavis Pharma

This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).
FLURANDRENOLIDE TOPICAL M
This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).