METHOXSALEN, USP 5GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name METHOXSALEN USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) 8-MOP Xanthotoxin Ammoidin Methoxsalen 9-Methoxyf uro[3,2-g][1]benzopyran-7-one Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Acute toxicity, Oral (Category 4), Skin sensitization (Category 1) Signal Word Warning Hazard Statement(s) H302 Harmf ul if swallowed H317 May cause an allergic skin reaction Pictogram(s) Precautionary Statement(s) P261 Avoid breathing dust/f ume/gas/mist/vapours/spray. P264 Wash hands thoroughly af ter handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P301+P312 IF SWALLOWED Call a POISON CENTER or doctor/physician if you f eel unwell. P302+P352 IF ON SKIN Wash with soap and water. P330 Rinse mouth. P333+P313 If skin irritation or a rash occurs Get medical advice/attention. P363 Wash contaminated clothing bef ore reuse. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified Photosensitizer Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name 8-MOP Xanthotoxin Ammoidin Methoxsalen 9-Methoxyf uro[3,2-g][1]benzopyran-7-one Common Name 8-Methoxypsoralen CAS Number 298-81-7 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice Consult a physician. Show this saf ety data sheet to the doctor in attendance. Move out of dangerous area. If Inhaled If breathed in, move person into fresh air. If not breathing, give artif icial reparation. Consult a physician. In Case of Skin Contact Wash of f with soap and plenty of water. Consult a physician. In Case of Eye Contact Flush eyes with water as a precaution. If Swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most Important Symptoms and Effects The most important known symptoms and ef f ects are described in the labeling (see section 2.2) and/or in section 11. Page 1 of 4 Section 5: Fire Fighting Measures Suitable Extinguishing Media Use water spray, alcohol-resistant f oam, dry chemical or carbon dioxide. Special Hazards Arising From the Substance/Mixture Carbon oxides. Special PPE and/or Precautions for Firefighters Wear self contained breathing apparatus f or f ire f ighting if necessary. Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Use personal protective equipment. Avoid dust f ormation. Avoid breathing vapours, mist, or gas. Ensure adequate ventilation. Avoid breathing dust. Methods and Materials Used for Containment Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Cleanup Procedures Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Do not let product enter drains. Section 7: Handling and Storage Precautions for Safe Handling Avoid contact with skin and eyes. Avoid f ormation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is f ormed. Conditions for Safe Storage Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep in a dry place. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Contains no substances with occupational exposure limit values. Appropriate Engineering Controls Handle in accordance with good industrial hygiene and saf ety practice. Wash hands bef ore breaks and at the end of workday. PPE - Eye/Face Protection Face shield and saf ety glasses. Use equipment f or eye protection tested and approved under appropriate government standards such as NIOSH (US) or ENN 166 (EU). PPE - Skin Protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Body Protection Complete suit protecting against chemicals, the type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specif ic workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Respiratory Protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For high level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Page 2 of 4 Section 9: Physical and Chemical Properties Appearance Form: Powder Colour: Light Yellow Upper/Lower Flammability or Explosive Limits No data available Odor No data available Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH No data available Relative Density No data available Melting Point/Freezing Point Melting point/range: 148 - 150 �C (298 - 302 �F) - lit. Solubility No data available Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient No data available Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Section 10: Stability and Reactivity Reactivity No data available Chemical Stability Stable under recommended storage conditions. Possibility of Hazardous Reactions No data available Conditions to Avoid No data available Incompatible Materials Strong oxidizing agents. Hazardous Decomposition Products Other decomposition products-No data available Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Oral - rat - 791 mg/kg Remarks: Behavioral: Convulsions or ef f ect on seizure threshold. Behavioral: Change in motor activity (specif ic assay). Behavioral: Ataxia. Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal No data available Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation Causes photosensitivity. Exposure to light can result in allergic reactions resulting in dermatologic lesions, which can vary from sunburn like responses to edematous, vesiculated lesions, or bullae. Germ Cell Mutagenicity No data available Carcinogenicity IARC 1-Group-1: Carcinogenic to humans (9-Methoxyf uro[3,2-g]chromen-7-one) Carcinogenicity ACGIH No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by ACGIH. Carcinogenicity NTP Known to human carcinogen (9-Methoxyf uro[3,2-g]chromen-7-one) Carcinogenicity OSHA No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by OSHA. Reproductive Toxicity Laboratory experiments have shown teratogenic ef f ects. Specific Target Organ Toxicity - Single Exposure No data available Specific Target Organ Toxicity - Repeated Exposure No data available Aspiration Hazard No data available Page 3 of 4 Section 12: Ecological Information Toxicity No data available Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Of f er surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed prof essional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an af terburner and scrubber. Waste Treatment Methods Packaging Dispose of as unused product. Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number Not dangerous goods. UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards N/A Section 15: Regulatory Information SARA 302 Components: SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components: SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards: Acute Health Hazard, Chronic Health Hazard. Massachusetts Right To Know Components: No components are subject to the Massachusetts Right To Know Act. Pennsylvania Right To Know Components: 9- Methoxyf uro[3,2-g]chromen-7-one CAS-No. 298-81-7 Revision Date 1990-01-01. New Jersey Right To Know Components: 9-Methoxyf uro[3,2- g]chromen-7-one CAS-No. 298-81-7 Revision Date 1990-01-01. Calif ornia Prop. 65 Components: WARNING: This product contains a chemical known to the State of Calif ornia to cause cancer. 9-Methoxyf uro[3,2-g]chromen-7-one CAS-No. 298-81-7 Revision Date 1987-02-27. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/11/2019 09:33 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
