ISOXSUPRINE HCL, USP 25KG by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name ISOXSUPRINE HCL USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) (1RS,2SR,1'SR)-1-(p-Hydroxyphenyl)-2-(1'-methyl-2'- pheNOxyethylamino)-1-propanol hydrochloride, mixture of enantiomers Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Acute toxicity, Oral (Category 4), Acute aquatic toxicity (Category 1), Chronic aquatic toxicity (Category 1) Signal Word Warning Hazard Statement(s) H302 Harmf ul if swallowed H410 Very toxic to aquatic lif e with long lasting ef f ects Pictogram(s) Precautionary Statement(s) P264 Wash hands thoroughly af ter handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301+P312 IF SWALLOWED Call a POISON CENTER or doctor/physician if you f eel unwell. P330 Rinse mouth. P391 Collect spillage. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name (1RS,2SR,1'SR)-1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-pheNOxyethylamino)-1-propanol hydrochloride, mixture of enantiomers Common Name Isoxsuprine HCL CAS Number 579-56-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice Consult a physician. Show this saf ety data sheet to the doctor in attendance. Move out of the dangerous area. If Inhaled If breathed in, move person into fresh air. If not breathing, give artif icial respiration. Consult a physician In Case of Skin Contact Wash of f with soap and plenty of water. Consult a physician. In Case of Eye Contact Flush eyes with water as a precaution. If Swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most Important Symptoms and Effects The most important known symptoms and ef f ects are described in the labeling (see section 2.2) and/or section11. Section 5: Fire Fighting Measures Suitable Extinguishing Media Use water spray, alcohol-resistant f oam, dry chemical or carbon dioxide. Special Hazards Arising From the Substance/Mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas. Special PPE and/or Precautions for Firefighters Wear self contained breathing apparatus f or f ire f ighting if necessary. Page 1 of 4 Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Use personal protective equipment. Avoid dust f ormation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Methods and Materials Used for Containment Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Cleanup Procedures Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Prevent f urther leakage and spillage if saf e to do so. Do not let product enter drains. Discharge into the environment must be avoided. Section 7: Handling and Storage Precautions for Safe Handling Avoid contact with skin and eyes. Avoid f ormation of dust and aerosols. Further processing of solid materials may result in the f ormation of combustible dusts. The potential f or combustible dust f ormation should be taken into consideration bef ore additional processing occurs. Provide appropriate exhaust ventilation at places where dust is f ormed. Conditions for Safe Storage Keep container tightly closed in dry and well-ventilated place. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Contains no substances with occupational exposure limit values. Appropriate Engineering Controls Handle in accordance with good industrial hygiene and saf ety practice. Wash hands bef ore breaks and at the end of workday. PPE - Eye/Face Protection Saf ety glasses with side-shields conf orming to EN166 Use equipment f or eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU). PPE - Skin Protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Body Protection Complete suit protecting against chemicals. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specif ic workplace. Handle with gloves. Glove must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Respiratory Protection For nuisance exposure use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH or (US) or CEN (EU). Section 9: Physical and Chemical Properties Appearance Form: Crystalline Colour: Colourless Upper/Lower Flammability or Explosive Limits No data available Odor odourless Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH No data available Relative Density No data available Melting Point/Freezing Point Melting point/range: 220 - 222 �C (428 - 432 �F) Solubility No data available Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient log Pow: 1.387 Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Page 2 of 4 Section 10: Stability and Reactivity Reactivity No data available Chemical Stability Stable under recommended storage conditions. Possibility of Hazardous Reactions No data available Conditions to Avoid No data available Incompatible Materials Strong oxidizing agents. Hazardous Decomposition Products Other decomposition products-No data available Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Oral - rat - 1,750 mg/kg Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal LD50 Intraperitoneal - rat - 164 mg/kg LD50 Intraperitoneal - mouse - 185 mg/kg Remarks: Behavioral: Excitement. Respiratory disorder Gastrointestinal: Changes in structure or f unction of salivary glands. LD50 Intravenous - rat - 77 mg/kg LD50 Subcutaneous - dog - 143 mg/kg LD50 Intravenous - mouse - 61 mg/kg Remarks: Behavioral: Excitement. Respiratory disorder Gastrointestinal: Changes in structure or f unction of salivary glands. LD50 Intravenous - dog - 57 mg/kg Remarks: Behavioral: Ataxia. Cardiac: Change in rate. Prolonged skin contact may cause skin irritation and/or dermatitis. LD50 Subcutaneous - mouse - 1,500 mg/kg Remarks: Behavioral: Excitement. Respiratory disorder Gastrointestinal: Changes in structure or f unction of salivary glands. Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation No data available Germ Cell Mutagenicity No data available Carcinogenicity IARC No component of this product present at levels greater than or equal to 0.1% is identif ied as probable, possible or conf irmed human carcinogen by IARC. Carcinogenicity ACGIH No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by ACGIH. Carcinogenicity NTP No component of this product present at levels greater than or equal to 0.1% is identif ied as a known or anticipated carcinogen by NTP. Carcinogenicity OSHA No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by OSHA. Reproductive Toxicity Damage to f etus cannot be excluded. Developmental Toxicity - rat - Intravenous Specif ic Developmental Abnormalities: Hepatobiliary system. Specif ic Developmental Abnormalities: Endocrine system. Specific Target Organ Toxicity - Single Exposure No data available Specific Target Organ Toxicity - Repeated Exposure No data available Aspiration Hazard No data available Section 12: Ecological Information Toxicity No data available Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects An environmental hazard cannot be excluded in the event of unprof essional handling and disposal. Very toxic to aquatic lif e with long lasting ef f ects. Section 13: Disposal Considerations Waste Treatment Methods Product Of f er surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed prof essional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an af terburner and scrubber. Waste Treatment Methods Packaging Dispose of as unused product. Special Precautions Landfill or Incinerations No data available Other Information No data available Page 3 of 4 Section 14: Transport Information UN Number UN Proper Shipping Name Transport Hazard Class(es) Packaging Group Environmental Hazards Marine Pollutant: Marine Pollutant. Section 15: Regulatory Information Reach No. A registration number is not available f or this substance as the substance or its uses are exempted from registration, the annual tonnage does not require registration or the registration is envisaged f or a later registration deadline. SARA 302 Components: SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components: SARA 313: This material does not contain any chemical components with know CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards: Acute Health Hazard, Chronic Health Hazard. Massachusetts Right To Know Components: No components are subject to the Massachusetts Right To Know Act. Pennsylvania Right To Know Components: Isoxsuprine hydrochloride CAS-No. 579-56-6. New Jersey Right To Know Components: Isoxsuprine hydrochloride CAS-No. 579-56-6. Calif ornia Prop. 65 Components: This product does not contain any chemicals know to State of Calif ornia to cause cancer, birth def ects, or any other reproductive harm. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/11/2019 12:40 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
