BUSPIRONE HCL, USP 5GM by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name BUSPIRONE HCL USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dionehydrochloride Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Acute toxicity, Oral (Category 3) Signal Word Danger Hazard Statement(s) H301 Toxic if swallowed Pictogram(s) Precautionary Statement(s) P301+P310 IF SWALLOWED Immediately call a POISON CENTER or doctor/physician. Hazards Not Otherwise Classified No data Available Ingredient(s) with Unknown Toxicity No data available Section 3: Composition/Information on Ingredients Chemical Name Buspirone Hydrochloride Common Name Buspirone Hydrochloride CAS Number 33386-08-2 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice Consult a physician. Show this saf ety data sheet to the doctor in attendance. Move out of dangerous area. If Inhaled If breathed in, move person into fresh air. If not breathing, give artif icial respiration. Consult a physician. In Case of Skin Contact Wash of f with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In Case of Eye Contact Flush eyes with water as a precaution If Swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most Important Symptoms and Effects No data available Section 5: Fire Fighting Measures Suitable Extinguishing Media Use water spray, alcohol-resistant f oam, dry chemical or carbon dioxide. Special Hazards Arising From the Substance/Mixture Hazardous decomposition products f ormed under f ire conditions. - Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas. Special PPE and/or Precautions for Firefighters Wear self contained breathing apparatus f or f ire f ighting if necessary. Page 1 of 4 Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Wear respiratory protection. Avoid dust f ormation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to saf e areas. Avoid breathing dust. Methods and Materials Used for Containment Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Cleanup Procedures Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers f or disposal. Section 7: Handling and Storage Precautions for Safe Handling Avoid contact with skin and eyes. Avoid f ormation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is f ormed. Normal measures f or preventative f ire protection. Conditions for Safe Storage Preserve in tight, light-resistant containers, at controlled room temperature. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters Contains no substances with occupational exposure limit values. Appropriate Engineering Controls No data available PPE - Eye/Face Protection Face shield and saf ety glasses Use equipment f or eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). PPE - Skin Protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specif ic workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surf ace) to avoid skin contact with this product. Dispose of contaminated gloves af ter use in accordance with applicable laws and good laboratory practices. Wash and dry hands. PPE - Respiratory Protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirators cartridges. Use respirators and components tested and approved under appropriate Section 9: Physical and Chemical Properties Appearance Form: Solid, Color: No data available Upper/Lower Flammability or Explosive Limits No data available Odor No data available Vapor Pressure No data available Odor Threshold No data available Vapor Density No data available pH No data available Relative Density No data available Melting Point/Freezing Point No data available Solubility No data available Initial Boiling Point and Boiling Range No data available Flash Point No data available Evaporation Rate No data available Flammability (Solid, Gas) No data available Partition Coefficient No data available Auto-Ignition Temperature No data available Decomposition Temperature No data available Viscosity No data available Page 2 of 4 Section 10: Stability and Reactivity Reactivity No data available Chemical Stability Stable under recommended storage conditions. Possibility of Hazardous Reactions No data available Conditions to Avoid No data available Incompatible Materials Strong oxidizing agents. Hazardous Decomposition Products Hazard decomposition products f ormed under f ire conditions. - Carbon oxides, nitrogen oxides (NOx), hydrogen chloride gas Section 11: Toxicological Information Acute Toxicity - LD50 Oral LD50 Oral - rat - 196 mg/kg. Other inf ormation on acute toxicity: LD50 Intraperitoneal - mouse - 146 mg/kg. Remarks: Behavioral: Antipsychotic. Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal No data available Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation No data available Germ Cell Mutagenicity No data available Carcinogenicity IARC No component of this product present at levels greater than or equal to 0.1% is identif ied as probable, possible or conf irmed human carcinogen by IARC. Carcinogenicity ACGIH No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by ACGIH. Carcinogenicity NTP No component of this product present at levels greater than or equal to 0.1% is identif ied as a known or anticipated carcinogen by NTP. Carcinogenicity OSHA No component of this product present at levels greater than or equal to 0.1% is identif ied as a carcinogen or potential carcinogen by OSHA. Reproductive Toxicity Reproductive toxicity - rat - Oral. Ef f ects on Newborn: Stillbirth. Ef f ects on Newborn: Viability index (e.g., # alive at day 4 per # born alive). Ef f ects on Newborn: Other postnatal measures or ef f ects. No data available. Teratogenicity: Developmental Toxicity - rat - Oral. Ef f ects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted f etus). Specif ic Developmental Abnormalities: Musculoskeletal system. No data available. Specific Target Organ Toxicity - Single Exposure No data available Specific Target Organ Toxicity - Repeated Exposure No data available Aspiration Hazard No data available Section 12: Ecological Information Toxicity No data available Persistence and Degradability No data available Bio-accumulative Potential No data available Mobility in Soil No data available Other Adverse Effects No data available Section 13: Disposal Considerations Waste Treatment Methods Product Of f er surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed prof essional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an af terburner and scrubber. Waste Treatment Methods Packaging Dispose of as unused product. Special Precautions Landfill or Incinerations No data available Other Information No data available Page 3 of 4 Section 14: Transport Information UN Number 2811 UN Proper Shipping Name Toxic solids, organic, n.o.s. (8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione monohydrochloride) Transport Hazard Class(es) 6.1 Packaging Group III Environmental Hazards No Section 15: Regulatory Information OSHA Hazards: Toxic by ingestion. SARA 302 Components: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards: Acute Health Hazard. Massachusetts Right To Know Components: No components are subject to the Massachusetts Right To Know Act. Pennsylvania Right To Know Components: 8-[4-[4-(2-Pyrimidinyl)- 1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione monohydrochoride, CAS-No. 33386-08-2, Revision Date. New Jersey Right To Know Components: 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-8-azaspiro[4.5]decane-7,9-dione monohydrochloride. Calif ornia Prop. 65 components: This product does not contain any chemicals known to State of Calif ornia to cause cancer, birth def ects, or any other reproductive harm. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/15/2019 09:48 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
