AMOXICILLIN, USP (TRIHYDRATE) (POWDER) 25KG by Letco Medical Safety Data Sheet Section 1: Identification Common Name/Trade Name AMOXICILLIN TRIHYDRATE POWDER USP Supplier Information Letco Medical, LLC 1316 Commerce Drive NW Decatur, AL 35601 1 (800) 239-5288 +1 (734) 843-4693 IN CASE OF EMERGENCY: Chemtrec 1 (800) 424-9300 (24 hours) Product Synonym(s) N/A Relevant Use(s) of Product Manuf acture or Compounding of Substances Section 2: Hazards Identification Classification of Substance or Mixture Respiratory sensitization (Category 1), Skin sensitization (Category 1) Signal Word Danger Hazard Statement(s) H317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing dif f iculties if inhaled Pictogram(s) Precautionary Statement(s) P261 Avoid breathing dust/f ume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/f ace protection. P285 In case of inadequate ventilation wear respiratory protection. P302+P352 IF ON SKIN Wash with soap and water. P304+P341 IF INHALED If breathing is dif f icult, remove victim to fresh air and keep at rest in a position comf ortable f or breathing. P333+P313 If skin irritation or a rash occurs Get medical advice/attention. P342+P311 If experiencing respiratory symptoms Call a POISON CENTER or doctor/physician. P501 Dispose of contents/container to an approved waste disposal plant. Hazards Not Otherwise Classified No data available Ingredient(s) with Unknown Toxicity No data Available Section 3: Composition/Information on Ingredients Chemical Name Amoxicillin Trihydrate Common Name Amoxicillin Trihydrate CAS Number 61336-70-7 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice In all cases of doubt, or when symptoms persist, seek medical attention. If Inhaled Remove victim to fresh air and keep at rest in a position comf ortable f or breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician In Case of Skin Contact Wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Take of f contaminated clothing and wash bef ore reuse. In Case of Eye Contact Rinse cautiously with water f or several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If Swallowed Rinse mouth with water. Never give anything by mouth to an unconscious person. Call a POISON Center or doctor/physician if you f eel unwell. Most Important Symptoms and Effects May cause sensitisation by inhalation and skin contact. May cause an allergic reaction, especially in case of existing sensitivity to penicillins. Acute ef f ects: Possible eye, skin, gastrointestinal and/or respiratory tract irritation. Chronic ef f ects: Possible hypersensitization, superinf ections, and antibiotic-associated pseudomembranous colitis. Symptoms may be delayed. Treat symptomatically. Page 1 of 4 Section 5: Fire Fighting Measures Suitable Extinguishing Media Water spray, dry chemical, carbon dioxide or f oam as appropriate f or surrounding f ire and materials. Do not use a heavy water stream. Special Hazards Arising From the Substance/Mixture Emits toxic f umes under f ire conditions: Carbon monoxide. Carbon dioxide. Sulf ur compounds. Nitrogen oxides. Special PPE and/or Precautions for Firefighters Evacuate personnel to a saf e area. Firef ighters should use self-contained breathing equipment and protective clothing. Do not f lush into surf ace water or sanitary sewer system. Section 6: Accidental Release Measures Personal Precautions, Protective Equipment and Emergency Procedures Prevention of skin and eye contact. Avoid breathing dust. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to saf e areas. Methods and Materials Used for Containment Avoid release to the environment. Avoid discharge into drains, surf ace water or groundwater. Cleanup Procedures Wipe up spillage or collect spillage using a high ef f iciency vacuum cleaner. Place spillage in appropriately labeled container f or disposal Wash spill site. Section 7: Handling and Storage Precautions for Safe Handling Use personal protective equipment as required. Minimize dust generation and accumulation. Do not get in eyes on skin or clothing. Wash thoroughly af ter handling. Remove contaminated clothing and wash bef ore reuse. Use with adequate ventilation. Do not eat, drink or smoke when using this product. Take precautionary measures against electrostatic charging. Handle in accordance with good industrial hygiene and saf ety procedures. Conditions for Safe Storage Preserve in tightly closed containers, protected from light. Keep away from heat and ignition sources. Section 8: Exposure Controls/Personal Protection Components with Workplace Control Parameters No exposure limit values available Appropriate Engineering Controls Provide local exhaust or process enclosure ventilation system. PPE - Eye/Face Protection Wear Saf ety glasses or goggles. PPE - Skin Protection Wear rubber gloves PPE - Body Protection Wear rubber gloves PPE - Respiratory Protection Wear approved mask. In case of insuf f icient ventilation, wear suitable respiratory equipment. Section 9: Physical and Chemical Properties Appearance White to of f-white crystalline powder Upper/Lower Flammability or Explosive Limits Not available Odor Practically odorless Vapor Pressure Not applicable Odor Threshold Not available Vapor Density Not applicable pH 3.5 - 5.5 (0.2% aqueous solution) Relative Density Not available Melting Point/Freezing Point >194°C Solubility Slightly soluble in water, very soluble in ethanol (96 percent), practically insoluble in f atty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides. Initial Boiling Point and Boiling Range Not available Flash Point Not applicable Evaporation Rate Not applicable Flammability (Solid, Gas) Not available Partition Coefficient Log Pow: -0,124 at 20°C Auto-Ignition Temperature 530°C (dust cloud) Decomposition Temperature Not available Viscosity Not applicable Page 2 of 4 Section 10: Stability and Reactivity Reactivity Stable under normal conditions of use. Chemical Stability Stable if stored according to specif ication Possibility of Hazardous Reactions Will not polymerize under normal temperature and pressure Conditions to Avoid Moisture, heat, light, sources of ignition, incompatible materials Incompatible Materials Oxidizing agents. Hazardous Decomposition Products Emits toxic f umes under f ire conditions: Carbon monoxide. Carbon dioxide. Sulf ur compounds. Nitrogen oxides. Section 11: Toxicological Information Acute Toxicity - LD50 Oral Oral LD50 > 15,000 mg/kg (rat) Acute Toxicity - Inhalation No data available Acute Toxicity - Dermal No data available Acute Toxicity - Eye No data available Skin Corrosion/Irritation No data available Serious Eye Damage/Irritation No data available Respiratory or Skin Sensitazation May cause allergic respiratory reaction. May cause allergic skin reaction. Shows cross-allergencity with penicillin. May cause allergic respiratory and skin reactions. Germ Cell Mutagenicity No data available Carcinogenicity IARC No carcinogenicity Carcinogenicity ACGIH No carcinogenicity Carcinogenicity NTP No carcinogenicity Carcinogenicity OSHA No carcinogenicity Reproductive Toxicity No reproductive toxicity. Specific Target Organ Toxicity - Single Exposure No inf ormation available Specific Target Organ Toxicity - Repeated Exposure No inf ormation available Aspiration Hazard No inf ormation available Section 12: Ecological Information Toxicity Ecology - general: Small amounts: Hazardous waste. Use suitable disposal containers. Large amounts: Not applicable. Ecology - water: Soluble in water. Ecological toxicity: Fish: LC50: > 1000 mg/L/96h. Daphnia: EC50: >2300 ml/l (48h) Persistence and Degradability Biodegradable 88% Bio-accumulative Potential Log Pow: -0,124 at 20�?°C Mobility in Soil No inf ormation available Other Adverse Effects No inf ormation available Section 13: Disposal Considerations Waste Treatment Methods Product Dispose of this material and its container at hazardous or special waste collection point. Dispose of material in accordance with applicable local, state, and f ederal regulations. Waste Treatment Methods Packaging No data available Special Precautions Landfill or Incinerations No data available Other Information No data available Section 14: Transport Information UN Number Not dangerous goods UN Proper Shipping Name N/A Transport Hazard Class(es) N/A Packaging Group N/A Environmental Hazards N/A Page 3 of 4 Section 15: Regulatory Information EINECS: CAS # 64485-93-4 is not listed. DSD (67/548/EEC): CAS # 64485-93-4 is not listed. USA - TSCA: not listed. Canada - DSL: not listed. Australia - AICS: not listed. Korea - ECL: not listed. Japan - ENCS: not listed. China - IECSC: not listed. Section 16: Other Information Additional Information N/A Prepared By Lisa Russell Revision Date 01/15/2019 14:58 Disclaimer Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage resulting from handling, storage, use or from contact with the above product. Page 4 of 4
