ACETAMINOPHEN, USP (POWDER) 1KG by Letco Medical Safety Data Sheet
Section 1: Identification
Common Name/Trade Name ACETAMINOPHEN POWDER
Supplier Information
Letco Medical, LLC
1316 Commerce Drive NW
Decatur, AL 35601
1 (800) 239-5288
+1 (734) 843-4693
IN CASE OF EMERGENCY:
Chemtrec
1 (800) 424-9300 (24 hours)
Product Synonym(s) Paracetamol
Relevant Use(s) of Product Manuf acture or Compounding of Substances
Section 2: Hazards Identification
Classification of Substance
or Mixture Acute toxicity, Oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2)
Signal Word Warning
Hazard Statement(s) H302 Harmf ul if swallowed
H412 Harmf ul to aquatic lif e with long lasting ef f ects
Pictogram(s)
Precautionary Statement(s)
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED Call a POISON CENTER or doctor/physician if you f eel unwell.
Hazards Not Otherwise
Classified Possible sensitizer
Ingredient(s) with Unknown
Toxicity
No data Available
Section 3: Composition/Information on Ingredients
Chemical Name Acetamide, N-(4-hydroxyphenyl)-
Common Name Acetaminophen
CAS Number 103-90-2
Impurities and/or Stabilizing
Additives No data available
Section 4: First Aid Measures
General Advice
Remove from exposure. Remove contaminated clothing. . If person is not breathing, give artif icial respiration. If
breathing is dif f icult, give oxygen if available. Persons developing serious hypersensitivity (anaphylactic)reactions must
receive immediate medical attention.
If Inhaled Escape from the site to areas with fresh air immediately to keep breath smoothly. If breathing is dif f icult give oxygen.
In Case of Skin Contact Remove contaminated clothing. Clean the contaminated skin with lots of water.
In Case of Eye Contact Draw the eyelid, and clean with water. Obtain medical attention.
If Swallowed
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Human systemic ef f ects by ingestion: changes
in exocrine pancreas, diarrhea, nausea, irritability, somnolence, general anesthesia, f ever, hepatitis, kidney tubule
damage. Persons developing serious hypersensitivity (anaphylactic)reactions must receive immediate medical attention.
Most Important Symptoms
and Effects
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Section 5: Fire Fighting Measures
Suitable Extinguishing
Media Water spray, dry chemical, carbon dioxide, or f oam as appropriate f or surrounding f ire and materials
Special Hazards Arising
From the
Substance/Mixture
Explosion hazard: Avoid generating dust; f ine dust dispersed in air in suf f icient concentrations and in the presence of
an ignition source is a potential dust explosion hazard.
Special PPE and/or
Precautions for Firefighters
Wear suitable protective equipment. As with all f ires, evacuate personnel to a saf e area. Firef ighters should use selfcontained breathing equipment and protective clothing. Cool containers exposed to f lames with water until well af ter
the f ire is out. Page 1 of 4
Section 6: Accidental Release Measures
Personal Precautions,
Protective Equipment and
Emergency Procedures
Dust deposits should not be allowed to accumulate on surf aces, as these may f orm an explosive mixture if they are
released into the atmosphere in suf f icient concentration. Keep unnecessary personnel away. Do not touch damaged
containers or spilled material unless wearing appropriate protective clothing. Avoid inhalation of dust from the spilled material. Ensure adequate ventilation. Wear appropriate personal protective equipment.
Methods and Materials
Used for Containment
Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during
clean-up. For waste disposal, see section 13 of the SDS. Wash spill site.
Cleanup Procedures Sweep up or vacuum up spillage and collect in suitable container f or disposal. Avoid the generation of dusts during
clean-up. For waste disposal, see section 13 of the SDS. Wash spill site.
Section 7: Handling and Storage
Precautions for Safe
Handling
Operate in sealed containers, and equip with local exhaust system. Operators should be trained bef ore starting
working. Ensure they could operate f ollowing related procedures strictly and wear rubber gloves. Keep away from f ire
and heat source. Prohibit from smoking at working site. Use explosive-proof ventilation system and equipment. Avoid
dust producing, oxidants or reduction alkali contacting. Load or unload lightly, to prevent containers damage. Equip with
appropriate quantity and type of f iref ighting f acilities and emergency response kits f or spillage.
Conditions for Safe Storage
Keep away from f ire and heat source. Prohibit from smoking at working site. Use explosive-proof ventilation system
and equipment. Avoid dust producing, oxidants or reduction alkali contacting. Load or unload lightly, to prevent
containers damage. Equip with appropriate quantity and type of f iref ighting f acilities and emergency response kits f or
spillage.
Section 8: Exposure Controls/Personal Protection
Components with
Workplace Control
Parameters
4000ug/m3 (8 hours)
Appropriate Engineering
Controls
Seal well, and install local exhaust system, and equip with saf ety shower and eye washing f acility. Exposure Controlling methods have been established based on the OEL, Occupational Hazard Category and risk assessment of special
operations. Local exhaust ventilation (LEV) is recommended. Prohibit smoking, eating or drinking at production site.
Change and clean working clothes in time. Don�?¢??t drink liquor bef ore working. Shower with warm water. Carry out
health examination bef ore employment and periodical re-examination af ter employment.
PPE - Eye/Face Protection Wear approved f ull f ace protection (e.g. saf ety glasses with side shields or cover goggles and a f ace shield) if eye
contact is possible
PPE - Skin Protection
The selection gloves of gloves f or a specif ic activity must be based on the material�?¢??s properties and on
possible permeation and degradation that may occur under the circumstances or use. Glove selection must take into
account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g.
Latex) and theref ore these should be avoided. Care must be exercised if insuf f icient data are available and f urther
guidance should be sought from your local EHS department.
PPE - Body Protection
The selection gloves of gloves f or a specif ic activity must be based on the material�?¢??s properties and on
possible permeation and degradation that may occur under the circumstances or use. Glove selection must take into
account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g.
Latex) and theref ore these should be avoided. Care must be exercised if insuf f icient data are available and f urther
guidance should be sought from your local EHS department.
PPE - Respiratory
Protection
If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations resent, required
protection f actor as well as hazards, physical properties and warning properties of substances present. Follow local
regulations f or respirator use in the workplace.
Page 2 of 4
Section 9: Physical and Chemical Properties
Appearance White powder
Upper/Lower Flammability
or Explosive Limits Not available.
Odor Odorless.
Vapor Pressure 0.0000003 kPa at 25 �C
Odor Threshold Not available.
Vapor Density Not available.
pH 5.5-6.5 of 10% solution at 20oC
Relative Density Not available.
Melting Point/Freezing
Point
168 � 172 ℃
Solubility Solubility in water: Soluble in hot water.
Initial Boiling Point and
Boiling Range
> 932 �F (> 500 �C)
Flash Point N/A
Evaporation Rate Not available.
Flammability (Solid, Gas) Not applicable.
Partition Coefficient Partition coef f icient (n-octanol/water: 0.46 - 0.51
Auto-Ignition Temperature > 356 �F (> 180 �C)
Decomposition
Temperature No data available
Viscosity No data available
Section 10: Stability and Reactivity
Reactivity No data available
Chemical Stability Stable
Possibility of Hazardous
Reactions No data available
Conditions to Avoid Strong acids. Strong bases. Strong oxidizing agents. Avoid direct sunlight, conditions that might generate heat and
dispersion as a dust cloud
Incompatible Materials Strong acids. Strong bases. Strong oxidizing agents.
Hazardous Decomposition
Products Polymerization hazard No polymerizations Decomposing material CO, CO2, NO
Section 11: Toxicological Information
Acute Toxicity - LD50 Oral Adverse ef f ects might occur f ollowing ingestion Acute: Rat LD50: 1944mg/kg
Acute Toxicity - Inhalation No studies have been conducted
Acute Toxicity - Dermal Minor irritation might occur f ollowing direct contact with intact skin Primary Irritation Index: 0.3 Intact
Acute Toxicity - Eye Minor irritation might occur f ollowing direct contact with eyes Kay and Calandra Class: 4
Skin Corrosion/Irritation No data available
Serious Eye
Damage/Irritation No data available
Respiratory or Skin
Sensitazation
Sensitisation (allergic skin reaction) is not expected. Assessment based upon ef f ects of structurally similar
substances..
Germ Cell Mutagenicity Not expected to be genotoxic under occupational exposure conditions
Carcinogenicity IARC No data available. Not expected to produce cancer in humans under occupational exposure conditions
Carcinogenicity ACGIH No data available. Not expected to produce cancer in humans under occupational exposure conditions
Carcinogenicity NTP No data available. Not expected to produce cancer in humans under occupational exposure conditions
Carcinogenicity OSHA No data available. Not expected to produce cancer in humans under occupational exposure conditions
Reproductive Toxicity
Not expected to produce adverse ef f ects on f ertility or development under occupational exposure conditions, Not
expected to impair the quantity of human breast milk under occupational exposure conditions.
Specific Target Organ
Toxicity - Single Exposure Adverse ef f ects might occur in the f ollowing organ(s) f ollowing overexposure: liver
Specific Target Organ
Toxicity - Repeated
Exposure
No data available
Aspiration Hazard No data available Page 3 of 4
Section 12: Ecological Information
Toxicity
Water: 0.0092mg/L ECOTOXIY Aquatic Microtox Microtox is a general toxicity test which utilizes a sensitive marine
photo bacteria as the test species. This material is not toxic to these Microorganisms. EC50: 1000mg/l, 30 minutes
Algal This material is not toxic to algae IC50: 134mg/l, 72Hours, Scenedesmus subspicatus, Green algae Daphnid This material is toxic to daphnids EC50: 9.2mg/l, 48 Hours, Daphnia magna, magna, Static test Fish This material is mot toxic
to f ish. Juvenile pimephales promelas, f athead minnow EC50: 814mg/l, 96 Hours, Flow-through test
Persistence and
Degradability
No data available
Bio-accumulative Potential No data available
Mobility in Soil
Solubility Based on this material�?¢??s aqueous solubility, f or environmental f ate predictions this material has
solubility in water. Volatility This material will not readily enter into the air from water. Henry�?¢??s Law Constant
6.42E-13atm m�???3/mol, Estimated Partitioning Based on this material�?¢??s octanol /water partition coef f icient,
f or environmental f ate predictions this material will not have the tendency to distribute into f ats.
Other Adverse Effects No data available
Section 13: Disposal Considerations
Waste Treatment Methods
Product Burn and control the waste gas. Remove the NO materials with syringe.
Waste Treatment Methods
Packaging
No data available
Special Precautions Landfill
or Incinerations No data available
Other Information No data available
Section 14: Transport Information
UN Number Not dangerous goods
UN Proper Shipping Name N/A
Transport Hazard Class(es) N/A
Packaging Group N/A
Environmental Hazards N/A
Section 15: Regulatory Information
Saf ety, health and environmental regulations/legislation specif ic f or the substance or mixture The product is not concerned by any specif ic regulation.
Nevertheless, check the conf ormity to regulations such as the directive 96/82/CE (Seveso) or directives relatives to wastes. Chemical saf ety
assessment No chemical saf ety assessment was made f or the substance.
Section 16: Other Information
Additional Information N/A
Prepared By Lisa Russell
Revision Date 01/15/2019 15:21
Disclaimer
Letco Medical, LLC believes that the above information is correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is
based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. If the product is used as a component in another
product, this information may not be applicable. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF MERCHANTABILITY OR ANY OTHER
WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED ABOVE. Letco Medical shall not be held liable for any loss or damage
resulting from handling, storage, use or from contact with the above product.
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