Please email us at [email protected] with our item No, NDC#, UPC# or the product link if you have any quetions. We are located in Oceanside, California. Search over 110,000 items by Name, Item No., NDC, UPC (without dashes) or by Mfg.Name. Please note, Prescription items can only be ordered by a Drug Manufacturer, Wholesaler, Hospital, Governmental Medical Facility, VA, Pharmacy, Physician, Physician Assistant, Nurse Practitioner, Dentist, Podiatrist, Optometrist, Veterinarian, Naturopath, Licensed Lab, Physical Therapist & Pharmacist in their scope of practice. No order will ship, unless you you have provided us the Medical License (and DEA Lic. in case of controlled drug) and we had verified that. Rx items can only be shipped to AZ, AR, CA, CT, DE, FL, GA, GU, HI, IL, KS, KY, LA, ME, MA, MI, NJ, NY, PA, PR, TX, TN, VA, WA, WI and WV. If you are an International Physician or Pharmacist, please contact us before ordering.


Rx Item-Zejula 100Mg Capsules 1X30 Ea By Tesaro Inc.

item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comZEJULA 100MG CAPSULES 1X90 EA by Tesaro Incitem No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com

Rx Item-Zejula 100Mg Capsules 1X30 Ea By Tesaro Inc.

$9146.16$0.01

Item No.: RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx70183-125-03 ZEJULA 100MG CAPSULES 1X30 EA by Tesaro Inc.ZEJULA 100MG CAPSULES 1X90 EA by Tesa

Have a question?

  Out of stock, please email us with the item number or product link at [email protected] for the quantity available, current pricing and eligibility to purchase.

For: Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

Zejula (niraparib) is an oral, poly ADP-ribose polymerase (PARP) inhibitor for the treatment of patients with ovarian, fallopian tube, or primary peritoneal cancer. ZEJULA- niraparib capsule
TESARO, Inc.

1 INDICATIONS AND USAGE

ZEJULA� is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy.

2 DOSAGE AND ADMINISTRATION

2.1 Recommended Dosage
The recommended dose of ZEJULA as monotherapy is 300 mg (three 100 mg capsules) taken orally once daily.

Instruct patients to take their dose of ZEJULA at approximately the same time each day. Each capsule should be swallowed whole. ZEJULA may be taken with or without food. Bedtime administration may be a potential method for managing nausea.



Patients should start treatment with ZEJULA no later than 8 weeks after their most recent platinum-containing regimen.

ZEJULA treatment should be continued until disease progression or unacceptable toxicity.

In the case of a missed dose of ZEJULA, instruct patients to take their next dose at its regularly scheduled time. If a patient vomits or misses a dose of ZEJULA, an additional dose should not be taken.

2.2 Dose Adjustments for Adverse Reactions
To manage adverse reactions, consider interruption of treatment, dose reduction, or dose discontinuation. The recommended dose modifications for adverse reactions are listed in Tables 1, 2 and 3.
DOSAGE FORMS AND STRENGTHS

100 mg capsule having a white body with "100 mg" printed in black ink, and a purple cap with "Niraparib" printed in white ink.
DESCRIPTION

Niraparib is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor.

The chemical name for niraparib tosylate monohydrate is 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole 7-carboxamide 4-methylbenzenesulfonate hydrate (1:1:1). The molecular formula is C26 H30 N4 O5 S and it has a molecular weight of 510.61 amu. The molecular structure is shown below:

Chemical Structure
(click image for full-size original)
Niraparib tosylate monohydrate is a white to off-white, non-hygroscopic crystalline solid. Niraparib solubility is pH independent below the pKa of 9.95, with an aqueous free base solubility of 0.7 mg/mL to 1.1 mg/mL across the physiological pH range.

Each ZEJULA capsule contains 159.4 mg niraparib tosylate monohydrate equivalent to 100 mg niraparib free base as the active ingredient. The inactive ingredients in the capsule fill are magnesium stearate and lactose monohydrate. The capsule shell consists of titanium dioxide, gelatin in the white capsule body; and FD&C Blue #1, FD&C Red #3, FD&C Yellow #5 and gelatin in the purple capsule cap. The black printing ink consists of shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, purified water, strong ammonia solution, potassium hydroxide and black iron oxide. The white printing ink consists of shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, sodium hydroxide, povidone and titanium oxide.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
Niraparib is an inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, PARP-1 and PARP-2, which play a role in DNA repair. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death. Increased niraparib-induced cytotoxicity was observed in tumor cell lines with or without deficiencies in BRCA1/2. Niraparib decreased tumor growth in mouse xenograft models of human cancer cell lines with deficiencies in BRCA1/2 and in human patient-derived xenograft tumor models with homologous recombination deficiency that had either mutated or wild type BRCA1/2.

item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390
AmericanPharmaWholesale.com
item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390

item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390
ZEJULA 100MG CAPSULES 1X90 EA
item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

ZEJULA 100MG CAPSULES 1X90 EA by Tesaro Inc
ZEJULA 100MG CAPSULES 1X90 EA
ZEJULA 100MG CAPSULES 1X90 EA by Tesaro Inc

item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390
AmericanPharmaWholesale.com
item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390

item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390
ZEJULA 100MG CAPSULES 1X90 EA
item No.:RX69656-0103-90 NDC No.69656010330 UPC No.:10369656103303 NDC No.69656-0103-30 69656-103-30 UPC/GTIN No. 103696-56103303 10369656103303 MPN 10390

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]