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RX ITEM-Sildenafil 100Mg Tab 30 Generic Viagra By Torrent Pharma

SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma.  Generic Name:
SILDENAFIL CITRATE
Description:
SILDENAFIL CITRATE TB 100MG 30 
NDC:
13668-0188-30  13668-188-30  13668018830  1366818830 BRAND: VIAGRA NDC: 13668-0188-30,13668018830 UPC: 3-13668-18830-1,313668188301 SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma.  Generic Name:
SILDENAFIL CITRATE
Description:
SILDENAFIL CITRATE TB 100MG 30 
NDC:
13668-0188-30  13668-188-30  13668018830  1366818830

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VIAGRA - sildenafil citrate tablet, film coated
DESCRIPTION

VIAGRA® , an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Sildenafil citrate is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d ]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
ildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7. VIAGRA (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration. In addition to the active ingredient, sildenafil citrate, each tablet contains the following inactive ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, lactose, triacetin, and FD & C Blue #2 aluminum lake.

CLINICAL PHARMACOLOGY

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). The approximately 4,000-fold selectivity for PDE5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see Pharmacodynamics).

In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro , an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.

VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 2563%). Its pharmacokinetics are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly cytochrome P450 3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil. The concomitant use of potent cytochrome P450 3A4 inhibitors (e.g., erythromycin, ketoconazole, itraconazole) as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil (see DOSAGE AND ADMINISTRATION). Both sildenafil and the metabolite have terminal half lives of about 4 hours
INDICATIONS & USAGE

VIAGRA is indicated for the treatment of erectile dysfunction.
OVERDOSAGE

In studies with healthy volunteers of single doses up to 800 mg, adverse events were similar to those seen at lower doses but incidence rates and severities were increased.

In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine.

DOSAGE & ADMINISTRATION

For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 4 hours to 0.5 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.

The following factors are associated with increased plasma levels of sildenafil: age >65 (40% increase in AUC), hepatic impairment (e.g., cirrhosis, 80%), severe renal impairment (creatinine clearance <30 mL/min, 100%), and concomitant use of potent cytochrome P450 3A4 inhibitors [ketoconazole, itraconazole, erythromycin (182%), saquinavir (210%)]. Since higher plasma levels may increase both the efficacy and incidence of adverse events, a starting dose of 25 mg should be considered in these patients.

Ritonavir greatly increased the systemic level of sildenafil in a study of healthy, non-HIV infected volunteers (11-fold increase in AUC, see Drug Interactions.) Based on these pharmacokinetic data, it is recommended not to exceed a maximum single dose of 25 mg of VIAGRA in a 48 hour period.

VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors or nitrates in any form is therefore contraindicated.

When VIAGRA is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment and VIAGRA should be initiated at the lowest dose (see Drug Interactions).

HOW SUPPLIED

VIAGRA (sildenafil citrate) is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to the nominally indicated amount of sildenafil as follows:

25 mg 50 mg 100 mg
Obverse VGR25 VGR50 VGR100
Reverse PFIZER PFIZER PFIZER
Bottle of 30 NDC-0069-4200-30 NDC-0069-4210-30 NDC-0069-4220-30
Bottle of 100 N/A NDC-0069-4210-66 NDC-0069-4220-66
Store at 25°C (77°F); excursions permitted to 1530°C (5986°F) [see USP Controlled Room Temperature].

SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma.  Generic Name:
SILDENAFIL CITRATE
Description:
SILDENAFIL CITRATE TB 100MG 30 
NDC:
13668-0188-30  13668-188-30  13668018830  1366818830
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SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma. Generic Name: SILDENAFIL CITRATE Description: SILDENAFIL CITRATE TB 100MG 30 NDC: 13668-0188-30 13668-188-30 13668018830 1366818830

BRAND: VIAGRA NDC: 13668-0188-30,13668018830 UPC: 3-13668-18830-1,313668188301 SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma
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BRAND: VIAGRA NDC: 13668-0188-30,13668018830 UPC: 3-13668-18830-1,313668188301 SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma.  Generic Name:
SILDENAFIL CITRATE
Description:
SILDENAFIL CITRATE TB 100MG 30 
NDC:
13668-0188-30  13668-188-30  13668018830  1366818830
RX ITEM-Sildenafil 100Mg Tab 30 Generic
SILDENAFIL 100MG TAB 30 Generic Viagra by Torrent Pharma. Generic Name: SILDENAFIL CITRATE Description: SILDENAFIL CITRATE TB 100MG 30 NDC: 13668-0188-30 13668-188-30 13668018830 1366818830