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Rx Item-Ezetimibe Generic Zetia 10Mg Tab 90 By Actavis (Teva) Pharma

NDC 66582-0414-28 UPC/GTIN No.3-66582-41428-5 Mfg.Part No.386128BRAND: ZETIA NDC: 00591-3713-19,591371319 UPC: 30591371319,30591371319 Merck & Co.Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Image 5 of Rx Item-Ezetimibe Generic Zetia 10Mg Tab 90 By Actavis (Teva) PharmaZetiaEzetimibe Generic Zetia 10mg Tab 30 by Actavis (Teva) Pharma  713
tablet , white , oblong oblong
White to off-whiteDebossed

Rx Item-Ezetimibe Generic Zetia 10Mg Tab 90 By Actavis (Teva) Pharma

$1016.71$46.48

Item No.:RX672436/c, Item No. RX672436, 672436, NDC No.: 00591-3713-19, 00591-713-19, 0059171319, 00591371319, 3713-19, 371319 UPC No. 3-05913-71319-2, 305913-713192, 305913713192, Rx Item-Ezetimibe Generic Zetia 10Mg Tab 90 By Actavis (Teva) Pharma Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Metabolic Agents-Antihyperlipidemic Agents-Cholesterol Absorption InhibitorsDrug Class: 24060500 Cholesterol Absorption Inhibitors

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ZETIA- ezetimibe tablet
Merck Sharp & Dohme Corp.


INDICATIONS AND USAGE
Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is indicated as an adjunct to diet when the response to a diet restricted in saturated fat and cholesterol and other nonpharmacologic measures alone has been inadequate.
1.1 Primary Hyperlipidemia
Monotherapy
ZETIA � , administered alone, is indicated as adjunctive therapy to diet for the reduction of elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia.
Combination Therapy with HMG-CoA Reductase Inhibitors (Statins)
ZETIA, administered in combination with a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin), is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, Apo B, and non-HDL-C in patients with primary (heterozygous familial and non-familial) hyperlipidemia.
Combination Therapy with Fenofibrate
ZETIA, administered in combination with fenofibrate, is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, Apo B, and non-HDL-C in adult patients with mixed hyperlipidemia.
1.2 Homozygous Familial Hypercholesterolemia (HoFH)
The combination of ZETIA and atorvastatin or simvastatin is indicated for the reduction of elevated total-C and LDL-C levels in patients with HoFH, as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.
1.3 Homozygous Sitosterolemia
ZETIA is indicated as adjunctive therapy to diet for the reduction of elevated sitosterol and campesterol levels in patients with homozygous familial sitosterolemia.
1.4 Limitations of Use
The effect of ZETIA on cardiovascular morbidity and mortality has not been determined.
ZETIA has not been studied in Fredrickson Type I, III, IV, and V dyslipidemias.
2 DOSAGE AND ADMINISTRATION
2.1 General Dosing Information
The recommended dose of ZETIA is 10 mg once daily.
ZETIA can be administered with or without food.
2.2 Concomitant Lipid-Lowering Therapy
ZETIA may be administered with a statin (in patients with primary hyperlipidemia) or with fenofibrate (in patients with mixed hyperlipidemia) for incremental effect. For convenience, the daily dose of ZETIA may be taken at the same time as the statin or fenofibrate, according to the dosing recommendations for the respective medications.
DOSAGE FORMS AND STRENGTHS
10-mg tablets are white to off-white, capsule-shaped tablets debossed with "414″ on one side.
DESCRIPTION
ZETIA (ezetimibe) is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. The chemical name of ezetimibe is 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone. The empirical formula is C24 H21 F2 NO3 .
CLINICAL PHARMACOLOGY
12.1 Mechanism of Action
Ezetimibe reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. In a 2-week clinical study in 18 hypercholesterolemic patients, ZETIA inhibited intestinal cholesterol absorption by 54%, compared with placebo. ZETIA had no clinically meaningful effect on the plasma concentrations of the fat-soluble vitamins A, D, and E (in a study of 113 patients), and did not impair adrenocortical steroid hormone production (in a study of 118 patients).
The cholesterol content of the liver is derived predominantly from three sources. The liver can synthesize cholesterol, take up cholesterol from the blood from circulating lipoproteins, or take up cholesterol absorbed by the small intestine. Intestinal cholesterol is derived primarily from cholesterol secreted in the bile and from dietary cholesterol.
Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (statins, bile acid sequestrants [resins], fibric acid derivatives, and plant stanols). The molecular target of ezetimibe has been shown to be the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is involved in the intestinal uptake of cholesterol and phytosterols.
Ezetimibe does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion. Instead, ezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of statins and of fenofibrate


NDC 66582-0414-28 UPC/GTIN No.3-66582-41428-5 Mfg.Part No.386128
RX ITEM-Ezetimibe Generic Zetia 10Mg Tab
NDC 66582-0414-28 UPC/GTIN No.3-66582-41428-5 Mfg.Part No.386128

BRAND: ZETIA NDC: 00591-3713-19,591371319 UPC: 30591371319,30591371319 Merck & Co.
Ezetimibe Generic Zetia 10Mg Tab 90 By A
BRAND: ZETIA NDC: 00591-3713-19,591371319 UPC: 30591371319,30591371319 Merck & Co.

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
EZETIMIBE ORAL TABLET 10
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Ezetimibe Generic Zetia 10mg Tab 30 by Actavis (Teva) Pharma  713
tablet , white , oblong oblong
White to off-whiteDebossed
00591-3713-30
Ezetimibe Generic Zetia 10mg Tab 30 by Actavis (Teva) Pharma 713 tablet , white , oblong oblong White to off-whiteDebossed