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Rx Item-Kyprolis 30Mg Vial By Onyx Pharma

Kyprolis by ONYX  PharmaKyprolis by ONYX  PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Kyprolis by ONYX  PharmaKyprolis by ONYX  Pharma

Rx Item-Kyprolis 30Mg Vial By Onyx Pharma

$1547.47$1473.78

item No.:RX76075-0102-01 NDC No.76075010201 UPC No.:376075102018 NDC No. 76075-0102-01 UPC/GTIN No. 3-76075-10201-8 MPN 10201 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx184341 Kyprolis 30mg Vial by ONYX PHARMA Item No. 3184341 NDC No. 76075-0102-01 UPC No.376075-102018 376075102018 Other Nam

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KYPROLIS- carfilzomib injection, powder, lyophilized, for solution
Onyx Pharmaceuticals, Inc.


1 INDICATIONS AND USAGE

1.1 Relapsed or Refractory Multiple Myeloma
Kyprolis is indicated in combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy [see Clinical Studies ( 14.1)].
Kyprolis is indicated as a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy [see Clinical Studies ( 14.2, 14.3)].
2 DOSAGE AND ADMINISTRATION

3. Use a 21 gauge or larger gauge needle (0.8 mm or smaller external diameter needle) to aseptically reconstitute each vial by slowly injecting 29 mL (for 60 mg vial) or 15 mL (for 30 mg vial) Sterile Water for Injection, USP, through the stopper and directing the solution onto the INSIDE WALL OF THE VIAL to minimize foaming.
2.1 Administration Precautions


� Hydration - Adequate hydration is required prior to dosing in Cycle 1, especially in patients at high risk of tumor lysis syndrome or renal toxicity. The recommended hydration includes both oral fluids (30 mL per kg at least 48 hours before Cycle 1, Day 1) and intravenous fluids (250 mL to 500 mL of appropriate intravenous fluid prior to each dose in Cycle 1). If needed, give an additional 250 mL to 500 mL of intravenous fluids following Kyprolis administration. Continue oral and/or intravenous hydration, as needed, in subsequent cycles. Monitor patients for evidence of volume overload and adjust hydration to individual patient needs, especially in patients with or at risk for cardiac failure [see Warnings and Precautions ( 5.1, 5.3)].

� Electrolyte Monitoring - Monitor serum potassium levels regularly during treatment with Kyprolis.

� Premedications - Premedicate with the recommended dose of dexamethasone for monotherapy or the recommended dexamethasone dose if on combination therapy [see Dosage and Administration ( 2.2)]. Administer dexamethasone orally or intravenously at least 30 minutes but no more than 4 hours prior to all doses of Kyprolis during Cycle 1 to reduce the incidence and severity of infusion reactions [see Warnings and Precautions ( 5.9)]. Reinstate dexamethasone premedication if these symptoms occur during subsequent cycles.

� Administration - Infuse over 10 or 30 minutes depending on the Kyprolis dose regimen [see Dosage and Administration ( 2.2)]. Do not administer as a bolus. Flush the intravenous administration line with normal saline or 5% dextrose injection, USP immediately before and after Kyprolis administration. Do not mix Kyprolis with or administer as an infusion with other medicinal products.

� Dose Calculation - Calculate the Kyprolis dose [see Dosage and Administration ( 2.2)] using the patient's actual body surface area at baseline. In patients with a body surface area greater than 2.2 m2 , calculate the dose based upon a body surface area of 2.2 m2.

?� Thromboprophylaxis - Thromboprophylaxis is recommended for patients being treated with the combination of Kyprolis with dexamethasone or with lenalidomide plus dexamethasone. The thromboprophylaxis regimen should be based on an assessment of the patient's underlying risks [see Warnings and Precautions ( 5.8)].

?� Infection Prophylaxis - Consider antiviral prophylaxis for patients being treated with Kyprolis to decrease the risk of herpes zoster reactivation.

?� Patients on Hemodialysis - Administer Kyprolis after the hemodialysis procedure.

Kyprolis by ONYX  Pharma
Kyprolis by ONYX Pharma
Kyprolis by ONYX Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CARFILZOMIB INTRAVEN VIAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Kyprolis by ONYX  Pharma
Kyprolis by ONYX Pharma
Kyprolis by ONYX Pharma