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Rx Item-Xtandi (Enzalutamide) 40Mg Gelcap 1X120 Ea By Astellas Pharma

XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas PharmaXTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas PharmaThis Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma

Rx Item-Xtandi (Enzalutamide) 40Mg Gelcap 1X120 Ea By Astellas Pharma

$14730.84$0.01

Item No.: RX00469-0125-99 NDC No.469012599 UPC No.:304690125990 NDC No.00469-0125-99 00469-125-99 UPC/GTIN No. 3-04690-12599-0 MPN 823412 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx661607 XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma Item No.3661607 NDC No.00469012599 00469125

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XTANDI- enzalutamide capsule
Astellas Pharma US, Inc.

1 INDICATIONS AND USAGE

XTANDI� is indicated for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC).

2 DOSAGE AND ADMINISTRATION

2.1 Dosing Information
The recommended dose of XTANDI is 160 mg (four 40 mg capsules) administered orally once daily. XTANDI can be taken with or without food [see Clinical Pharmacology (12.3)]. Swallow capsules whole. Do not chew, dissolve, or open the capsules.
DOSAGE FORMS AND STRENGTHS

XTANDI 40 mg capsules are white to off-white oblong soft gelatin capsules imprinted in black ink with ENZ
DESCRIPTION

Enzalutamide is an androgen receptor inhibitor. The chemical name is 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluoro-N -methylbenzamide.

The molecular weight is 464.44 and molecular formula is C21 H16 F4 N4 O2 S. The structural formula is:

Structural formula of Enzalutamide
(click image for full-size original)
Enzalutamide is a white crystalline non-hygroscopic solid. It is practically insoluble in water.

XTANDI is provided as liquid-filled soft gelatin capsules for oral administration. Each capsule contains 40 mg of enzalutamide as a solution in caprylocaproyl polyoxylglycerides. The inactive ingredients are caprylocaproyl polyoxylglycerides, butylated hydroxyanisole, butylated hydroxytoluene, gelatin, sorbitol sorbitan solution, glycerin, purified water, titanium dioxide, and black iron oxide.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
Enzalutamide is an androgen receptor inhibitor that acts on different steps in the androgen receptor signaling pathway. Enzalutamide has been shown to competitively inhibit androgen binding to androgen receptors and inhibit androgen receptor nuclear translocation and interaction with DNA. A major metabolite, N‑desmethyl enzalutamide, exhibited similar in vitro activity to enzalutamide. Enzalutamide decreased proliferation and induced cell death of prostate cancer cells in vitro , and decreased tumor volume in a mouse prostate cancer xenograft model.

XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma
RX ITEM-Xtandi (Enzalutamide) 40Mg Gelca
XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma

XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma
00469-0125-99
XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma

This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).
XTANDI ENZALUTAMIDE
This Item Can Only Be Ordered By A Drug Mfg, Wholesaler,Pharmacy,Physician, Dentist, Podiatrist, Optometrist,Veterinarian,Naturopath,Licensed Lab, Physical Therapist & Pharmacist(scope).

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma
00469-0125-99
XTANDI (ENZALUTAMIDE) 40MG GELCAP 1X120 EA by Astellas Pharma