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Rx Item-Cabometyx (Cabozantinib) 20mg (600 Mg) Tablets 1X30 Each By Exelixis P

NDC: 42388-0023-26  42388-023-26 
UPC: 342388-023265   342388023265
 
CABOMETYX 40mg tabItem No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426 Exelixis PharmaExelixis PharmacarbometyxVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comNDC: 42388-0023-26  42388-023-26 
UPC: 342388-023265   342388023265
 
CABOMETYX 40mg tabItem No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426

Rx Item-Cabometyx (Cabozantinib) 20mg (600 Mg) Tablets 1X30 Each By Exelixis P

$24181.73$21699.00

Cabometyx (Cabozantinib) 20mg (600 Mg) Tablets 1X30 Each By Exelixis P Item No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.Lab, Naturalist, Naturopath, NP, Optometrist, Pharmacist, PA, Physical Therapist, Podiatrist, Research Co., Uni., VA, Vet & Wholesalers In Scope Of their Practice Can Ord

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Cabometyx (Cabozantinib) 40mg (1200 Mg) Tablets 1X30 Each By Exelixis
Please call for availability and Rebate info on this item.

CABOMETYX- cabozantinib s-malate tablet
Exelixis, Inc.

1 INDICATIONS AND USAGE

CABOMETYX is indicated for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy.

2 DOSAGE AND ADMINISTRATION

2.1 Recommended Dose
Do not substitute CABOMETYX tablets with cabozantinib capsules.

The recommended daily dose of CABOMETYX is 60 mg. Do not administer CABOMETYX with food. Instruct patients not to eat for at least 2 hours before and at least 1 hour after taking CABOMETYX. Continue treatment until patient no longer experiences clinical benefit or experiences unacceptable toxicity.



Swallow CABOMETYX tablets whole. Do not crush CABOMETYX tablets.

Do not take a missed dose within 12 hours of the next dose.

Do not ingest foods (e.g., grapefruit, grapefruit juice) or nutritional supplements that are known to inhibit cytochrome P450 during CABOMETYX treatment.
DOSAGE FORMS AND STRENGTHS

60 mg CABOMETYX tablets are yellow film-coated, oval shaped with no score, and debossed with "XL" on one side and "60″ on the other side.

40 mg CABOMETYX tablets are yellow film-coated, triangle shaped with no score, and debossed with "XL" on one side and "40″ on the other side.

20 mg CABOMETYX tablets are yellow film-coated, round with no score, and debossed with "XL" on one side and "20″ on the other side.

4 CONTRAINDICATIONS

None.

5 WARNINGS AND PRECAUTIONS

5.1 Hemorrhage
Severe hemorrhage occurred with CABOMETYX. The incidence of Grade ≥ 3 hemorrhagic events was 2.1% in CABOMETYX-treated patients and 1.6% in everolimus-treated patients. Fatal hemorrhages also occurred in the cabozantinib clinical program.

Do not administer CABOMETYX to patients that have or are at risk for severe hemorrhage.
DESCRIPTION

COMETRIQ is the (S)-malate salt of cabozantinib, a kinase inhibitor. Cabozantinib (S)-malate is described chemically as N -(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N" -(4-fluorophenyl)cyclopropane- 1,1-dicarboxamide, (2S)-hydroxybutanedioate. The molecular formula is C28 H24 FN3 O5 �C4 H6 O5 and the molecular weight is 635.6 Daltons as malate salt. The chemical structure of cabozantinib (S)-malate salt is:

image of chemical structure of CABOMETYX
(click image for full-size original)
Cabozantinib (S)-malate salt is a white to off-white solid that is practically insoluble in aqueous media.

CABOMETYX (cabozantinib) tablets are supplied as film-coated tablets containing 20 mg, 40 mg, or 60 mg of cabozantinib, which is equivalent to 25 mg, 51 mg, or 76 mg of cabozantinib (S)-malate, respectively. CABOMETYX also contains the following inactive ingredients: microcrystalline cellulose, lactose anhydrous, hydroxypropyl cellulose, croscarmellose sodium, colloidal silicon dioxide, and magnesium stearate.

The film coating contains hypromellose, titanium dioxide, triacetin, and iron oxide yellow.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
In vitro biochemical and/or cellular assays have shown that cabozantinib inhibits the tyrosine kinase activity of MET, VEGFR-1, -2 and -3, AXL, RET, ROS1, TYRO3, MER, KIT, TRKB, FLT-3, and TIE-2. These receptor tyrosine kinases are involved in both normal cellular function and pathologic processes such as oncogenesis, metastasis, tumor angiogenesis, drug resistance, and maintenance of the tumor

NDC: 42388-0023-26  42388-023-26 
UPC: 342388-023265   342388023265
CABOMETYX 60mg tab
NDC: 42388-0023-26 42388-023-26 UPC: 342388-023265 342388023265

CABOMETYX 40mg tab
CABOMETYX 40mg tab
CABOMETYX 40mg tab

Item No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426
CABOMETYX 20mg tab
Item No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426

Exelixis Pharma
Exelixis Pharma
Exelixis Pharma

Exelixis Pharma
Exelixis Pharma
Exelixis Pharma

carbometyx
carbometyx
carbometyx

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com

NDC: 42388-0023-26  42388-023-26 
UPC: 342388-023265   342388023265
CABOMETYX 60mg tab
NDC: 42388-0023-26 42388-023-26 UPC: 342388-023265 342388023265

CABOMETYX 40mg tab
CABOMETYX 40mg tab
CABOMETYX 40mg tab

Item No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426
CABOMETYX 20mg tab
Item No.: RX42388-0024-26/C NDC No.42388002426 4238802426 UPC No.:342388024262 NDC No. 42388-0024-26 42388-024-26 UPC/GTIN No. 3-42388-02426-2 342388024262 342388-024262 MPN No. 2426