Insulin
Trade Names:
Caninsulin� (cartridge)
Caninsulin� (vial)
ProZinc�
Vetsulin�
General Description:
Insulin is an injectable medication used to control diabetic patients" blood sugar levels. Your veterinarian has chosen this product to most closely match your pet's natural insulin. Special insulin syringes (U-40) will be necessary to administer this product. Review the material below now and each time you refill this prescription.
What is this drug?
Insulin is a hormone that is naturally produced by the pancreas. It helps regulate blood sugar. When the body doesn't produce enough insulin or when it is produced but not effective, the result is diabetes. Administration of commercial insulin will slowly release insulin into your pet's body tissue.
Insulin is a simple molecule, but they do vary slightly between species. Your veterinarian will choose the best insulin for your pet.
Insulin is not a cure for diabetes, but a tool to control blood sugars and alleviate clinical signs
Insulin is given by injection under the skin
Reasons for prescribing:
Used to control hyperglycemia in dogs and cats with diabetes mellitus
This medication will cause the blood sugar to go down
What dogs/cats should not take this medication?
The safety and effectiveness in puppies and kittens, as well as breeding, pregnant and nursing dogs and cats has not been evaluated
Pets who have stopped eating, are anorexic, vomiting, showing signs of extreme drowsiness or fatigue and/or showing signs of severe ketoacidosis
Pets known to have had an allergic reaction to Insulin
Pets allergic to pork or beef should not use Insulin from either of these sources
Directions:
Veterinary Insulin proucts should be given subcutaneously (under the skin) using a U-40 insulin syringe only. Most human products are 100 units per milliliter, therefore would use a U-100 syringe. Some syringes are marked in units and milliliters. Be sure to use the unit scale.
Consult with your veterinarian to ensure you are using the correct syringe for the product prescribed. Ensure you use the correct syringe or you will likely cause incorrect dosing. Accurate dosing/measuring is critical.
Insulin syringes bought at the drugstore may require a prescription.
Feed your pet, make sure that a reasonable amount has been eaten and then give the Insulin. If you think your pet is off food or not eating well, do not give the insulin and notify your vet.
Meals should be approximately equal and fed ~12 hours apart.
Giving the injection:
Just prior to use, gently roll the vial between the palms of your hands ~10 times. Do not shake.
When drawing up the Insulin, always hold the bottle vertically to avoid unnecessary bubbles in the syringe. If you get bubbles in the syringe, flick the syringe with fingers until the bubble rises to the top and simple plush the air out of the syringe with the plunger.
Before injecting Insulin, allow it to come to room temperature in the syringe. Pull up a handful of your pet's scruff. A triangle of skin is formed. Aim your needle for the center of this triangle and stick in the needle. Do not be shy or the needle will not penetrate the thick skin. Pull back slightly on the syringe plunger to ensure you do not get blood back in the syringe. If you see blood, pull the syringe and start over in a slightly different location. If you do not see blood, press the plunger forward and deliver the insulin dose. Reward your pet!
Remember to rotate the injection sites with each injection.
If there is struggling or your pet escapes and you are not sure if your pet got the entire dose of Insulin, do not give more, but wait until the next scheduled dose.
Dosage regimens vary greatly among patients. The goal is to maintain blood sugar levels in an acceptable range over the course of the day, by giving injections once or twice a day (usually twice).
Peak effect is ~4-10 hours after dose is given.
Keeping the sugars in proper range will control your pet's excessive urination and appetite. Trial and error with dosing will be necessary and will be adjusted based upon your pet's blood glucose levels and improvement of other clinical signs.
Further adjustments may be necessary to the pet's diet (high protein/low carbohydrate - cats; high fiber - dogs), body weight or other medications.
Follow any diet or exercise plan developed for your pet by your veterinarian.
Do not give a dose of Insulin if the pet is experiencing low blood glucose (hypoglycemia). Common causes for hypoglycemia include: excessive doses of Insulin, failure to eat, accidental doubling of Insulin dose, strenuous exercise, drug effects.
Do not give Insulin if the pet has not eaten for 12-24 hours.
Do not change the pet's food, feeding schedule or exercise schedule once regulated. Unscheduled treats should be avoided.
Lantus is a clear liquid; the other insulins are cloudy when gently mixed. Discard opened bottles after 4 weeks.
Ensure you always have at least two bottles of Insulin on hand.
Ensure your pet has fresh, clean drinking water at all times. Monitoring water consumption and urination amount is a good indication of glucose control.
What if dose is missed?
If you miss a dose, give it as soon as you remember it, but if it is within a few hours of the regularly scheduled dose, wait and give it at the regular time. Occasional missed doses are easily tolerated; overdoses can be fatal.
What to tell/ask your veterinarian before giving this medication?
Talk to your veterinarian about:
The signs of diabetes mellitus that you've noticed
When will your pet need to be rechecked. Frequent blood glucose tests will need to be done initially to determine the type of insulin to use and the correct dose required. After this has been determined, follow up blood checks will need to be done according to your veterinarian's advice.
It is not uncommon for a pet's Insulin requirement to change over time. Watch for weight loss, excessive appetite, thirst and urination. An adjustment to the Insulin dose may be necessary.
The importance of consistent daily injections, consistent weight, diet and exercise and home monitoring
Risks and benefits of using this drug
Tell your veterinarian about:
If your pet has experienced side effects on other drugs/products
If your pet has experienced digestive upset now or ever
If your pet has experienced liver, pancreas, thyroid, adrenal gland or kidney disease now or ever
If your pet has experienced any other medical problems or allergies now or ever
All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
If your pet is pregnant or nursing. Spaying your intact pet will likely be necessary.
Storage and Warnings:
Some insulins need to be refrigerated and others do not. Follow the manufacturer's recommendations. Do not freeze. Protect from light.
Just prior to use, gently roll the vial between the palms of your hands ~10 times. Do not shake.
Do not re-use a syringe. Dispose of all syringes in a 'Sharps" container or another appropriate puncture-resistant disposal container. Discuss disposal options for this container with your veterinarian.
Do not use any Insulin product after the labeled expirat'ion date.
Do not use any Insulin that has been frozen or exposed to direct heat or light.
Do not use the Insulin if the product has become discolored, has particles in it, or looks different than previous vials.
Discard opened bottles after 4 weeks.
Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.
Pet owners allergic to Insulin and/or other antibiotics should avoid handling this drug.
Potential side effects:
Pets allergic to pork or beef should not use insulin from either of these sources
Allergies are rare, but an allergic reaction would show as difficult breathing, hives, scratching, swollen lips, tongue or face, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs or coma. If you observe any of these symptoms, contact your veterinarian immediately.
Low blood sugar (hypoglycemia) is the most common side effect. It is caused by giving too much Insulin, missing or delaying food, changing the food or amount fed, increasing exercise, an infection or illness or a drug interaction.
Symptoms include disorientation, weakness, hunger, nausea, rapid heartbeat, lethargy, staggering, cold, possibly seizures and coma. Hypoglycemic cats may simply be inactive. Offer the pet food. If s/he won't eat, give the pet sugar (e.g. light Karo syrup) rubbed carefully onto the pet's gums. Swallowing is not necessary as the sugars are absorbed directly through the mucous membranes of the mouth. This should revive the pet within 1-2 minutes. Once your pet has responded and is sitting up, feed s/he a high-protein meal. Contact your veterinarian for the next step(s).
High blood sugar (hyperglycemia): notify your veterinarian immediately if the pet experiences drowsiness, dry mouth, flushed dry skin, increased urination, loss of appetite, nausea, vomiting, trouble breathing or unusual thirst.
Contact your veterinarian if you notice excessive water consumption for more than 3 days, excessive urination, loss of appetite, weakness, seizures, behavior change, muscle twitching, anxiety, constipation, vomiting, diarrhea, signs of a bladder infection (small, frequent urinations, straining, blood in the urine) or swelling of the head or neck
Dogs who are poorly regulated have a greater risk of developing cataracts
Females should be spayed as estrus will change Insulin requirements
If you notice anything unusual, contact your veterinarian
Can this drug be given with other medications?
Yes, but the dose may need to be adjusted. These drugs may interact with Insulin: anabolic steroids, alcohol, aspirin and other salicylates, beta-adrenergic blockers, cardiac glycosides, dextrothyroxine, dobutamine, epinephrine, estrogen/progesterone combinations, furosoemide, glucocorticoids, guanethidine, monoamine oxidase inhibitors, phenylbutazone, sulfinpyrazone, tetracycline, thiazide diuretics and thyroid medications.
Do not give any other prescription or over-the-counter drugs, including vitamins, minerals and herbal products, without first talking to your veterinarian.
If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
What should I do if I know of or suspect there has been an overdose?
Contact your veterinarian immediately if you inject more than the prescribed amount.
What else should I know?
Have your pet wear an identification tag that indicates it is a diabetic. Perhaps include your veterinarian's name and phone number.
Never leave home without sugar or corn syrup. Liquid glucose packets can be bought at your pharmacy. Become very aware of your pet's 'normal" behavior in order to determine when something is wrong.
There are urine dipstick tests that can help you measure urine glucose. If you detect ketones in the urine, this can be a very bad sign. Contact your veterinarian if urine ketones persist more than a couple of days.
Litter additives that detect glucose in urine are also available.
Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.
As with all prescribed medicines, Insulin should only be given to the dog/cat for which it was prescribed.
This is just a summary of information about Insulin. If you have any questions or concerns about Insulin or diabetes, contact your veterinarian.
CVP Number: 63000521
ProZinc� (Rx) Boehringer Ingelheim Ingredient(s):
insulin
Use:
Hyperglycemia associated with diabetes mellitus, control
Species:
Cats
RoA:
S.C.
Dose:
Dosage regimens will vary among patients.
Starting dose: 0.1-0.3 U/lb (0.2-0.7 U/kg) b.w. q12h, given with or right after a meal. Adjust dose based on changes in blood glucose levels and resolution of clinical signs. Further adjustments in dosage may be necessary with changes in diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.
ResiCort� Leave-On Lotion (Rx) Virbac Ingredient(s):
hydrocortisone
Use:
Pruritus, topical treatment
Species:
Cats, Dogs, Horses
RoA:
Topical
Dose:
After shampooing or wetting hair coat, apply sufficient amount of lotion to cover entire hair coat along animal's back. Amount will vary according to size and length of hair coat. Massage well into skin and hair coat. Apply more prn. May be used in localized areas or generally between shampoos.
Initially use 2-3 times/week for 2 weeks, then as directed by your veterinarian.
Salix� Tablets (Rx) Intervet/Merck Animal Health Ingredient(s):
furosemide
Use:
Edema (cardiac insufficiency), treatment
Species:
Cats
RoA:
Oral
Dose:
12.5 mg tablet: 1 per 5-10 lb b.w. once or twice daily with 6-8h between treatments. Lower dose is suggested for cats. Adjust dose to individual's response.
Severe edematous or refractory cases: Double dose or increase by increments of 1 mg/lb b.w.
Long-term treatment: Lower dose after edema has been reduced.
Use:
Edema (cardiac insufficiency), treatment
Species:
Dogs
RoA:
Oral
Dose:
50 mg tablet: 1/2-1 per 25 lb b.w. once or twice daily with 6-8h between treatments.
12.5 mg tablet: 1 per 5-10 lb b.w. once or twice daily with 6-8h between treatments.
Adjust dose to individual's response.
Severe edematous or refractory cases: Double dose or increase by increments of 1 mg/lb b.w.
Long-term treatment: Lower dose after edema has been reduced.
Tri-Heart� Plus Chewable Tablets (Rx) Intervet/Merck Animal Health Ingredient(s):
ivermectin, pyrantel pamoate
Use:
Heartworm disease, prevention
Roundworms/Hookworms, control/treatment
Species:
Dogs
RoA:
Oral
Dose:
Dogs >=6 weeks of age: Give at monthly intervals at recommended minimum dose level of 6 mcg ivermectin/kg (2.72 mcg/lb) and 5 mg pyrantel (as pamoate salt)/kg (2.27 mg/lb) b.w. The recommended dosing schedule is as follows:
Weight: Chewables/month: Ivermectin/pyrantel content: Color coded packaging
<25 lb: 1: 68 mcg/57 mg: Blue.
26-50 lb: 1: 136 mcg/114 mg: Green.
51-100 lb: 1: 272 mcg/227 mg: Brown.
>100 lb: Use appropriate combination of chewables.
Give at monthly intervals during period of year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. Initial dose must be given within 30d after dog's first exposure to mosquitoes. The final dose must be given within 30d after dog's last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart Plus must be given within 30d of the last dose of former medication.
Tri-Otic� (Rx) Med-Pharmex Ingredient(s):
betamethasone, clotrimazole, gentamicin
Use:
Otitis externa (with yeast), local treatment
Species:
Dogs
RoA:
Otic
Dose:
Clean and dry external ear well. Remove excessive hair. After verifying that eardrum is intact, instill 4 drops (2 drops from the 215 g bottle) q12h into ear canal of dogs <30 lb b.w. Use 8 drops (4 drops from the 215 g bottle) q12h for dogs >30 lb b.w. Continue for 7d.
Tumil-K� Powder (Rx) Virbac Ingredient(s):
potassium gluconate
Use:
Hypokalemia, treatment
Potassium supplementation
Kidney function support
Species:
Cats, Dogs
RoA:
Oral
Dose:
0.65 g (1/4 tsp)/10 lb (4.5 kg) b.w. BID with food. Adjust dosage prn.
Vetmedin� Chewable Tablets (Rx) Boehringer Ingelheim Ingredient(s):
pimobendan
Use:
Heart failure (caused by mitral regurgitation), treatment
Heart failure (caused by dilated cardiomyopathy), treatment
Species:
Dogs
RoA:
Oral
Dose:
0.23 mg/lb (0.5 mg/kg) b.w. Divide dose into two, and give q12h.
Zubrin� Tablets (Rx) Intervet/Merck Animal Health Ingredient(s):
tepoxalin
Use:
Pain/inflammation due to osteoarthritis, control of
Species:
Dogs
RoA:
Oral
Dose:
10 mg/kg (4.5 mg/lb) or 20 mg/kg (9.1 mg/lb) on initial day of treatment, followed by a daily maintenance dose of 10 mg/kg. Due to observed variability in tepoxalin metabolism, a higher initial dose of 20 mg/kg may be given to increase likelihood that plasma active metabolite levels will reach a minimum effective concentration following first oral administration (especially beneficial to dogs that show signs of severe osteoarthritic pain).
Duration of treatment at 10 mg/kg should be based on clinical response and patient tolerance of drug treatment.
Administer with food or within 1-2h after feeding. Due to tablet sizes, dogs weighing <3 kg (6.6 lb) cannot be accurately dosed.
ProZinc�
Boehringer Ingelheim
(protamine zinc recombinant human insulin)
NADA 141-297, Approved by FDA
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Description: ProZinc� insulin is a sterile aqueous protamine zinc suspension of recombinant human insulin.
Each mL contains:
recombinant human insulin
40 International Units (IU)
protamine sulfate
0.466 mg
zinc oxide
0.088 mg
glycerin
16.00 mg
dibasic sodium phosphate, heptahydrate
3.78 mg
phenol (added as preservative)
2.50 mg
hydrochloric acid
1.63 mg
water for injection (maximum)
1005 mg
pH is adjusted with hydrochloric acid and/or sodium hydroxide.
Indications: ProZinc (protamine zinc recombinant human insulin) is indicated for the reduction of hyperglycemia and hyperglycemia-associated clinical signs in cats with diabetes mellitus.
Dosage and Administration: USE OF A SYRINGE OTHER THAN A U-40 SYRINGE WILL RESULT IN INCORRECT DOSING.
FOR SUBCUTANEOUS INJECTION IN CATS ONLY.
DO NOT SHAKE OR AGITATE THE VIAL.
ProZinc insulin should be mixed by gently rolling the vial prior to withdrawing each dose from the vial. Once mixed, ProZinc suspension has a white, cloudy appearance. Clumps or visible white particles can form in insulin suspensions: do not use the product if clumps or visible white particles persist after gently rolling the vial.
Using a U-40 insulin syringe, the injection should be administered subcutaneously on the back of the neck or on the side of the cat.
Always provide the Cat Owner Information Sheet with each prescription.
The initial recommended ProZinc dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2 - 0.7 IU/kg) every 12 hours. The dose should be given concurrently with or right after a meal. The veterinarian should re-evaluate the cat at appropriate intervals and adjust the dose based on both clinical signs and glucose nadirs until adequate glycemic control has been attained. In the effectiveness field study, glycemic control was considered adequate if the glucose nadir from a 9-hour blood glucose curve was between 80 and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia, and weight loss were improved.
Further adjustments in the dosage may be necessary with changes in the cat's diet, body weight, or concomitant medication, or if the cat develops concurrent infection, inflammation, neoplasia, or an additional endocrine or other medical disorder.
Contraindications: ProZinc insulin is contraindicated in cats sensitive to protamine zinc recombinant human insulin or any other ingredients in the ProZinc product. ProZinc insulin is contraindicated during episodes of hypoglycemia.
Warnings: User Safety: For use in cats only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.
Animal Safety: Owners should be advised to observe for signs of hypoglycemia (see Cat Owner Information Sheet). Use of this product, even at established doses, has been associated with hypoglycemia. An animal with signs of hypoglycemia should be treated immediately. Glucose should be given orally or intravenously as dictated by clinical signs. Insulin should be temporarily withheld and, if indicated, the dosage adjusted.
Any change in insulin should be made cautiously and only under a veterinarian's supervision. Changes in insulin strength, manufacturer, type, species (human, animal) or method of manufacture (rDNA versus animal-source insulin) may result in the need for a change in dosage.
Appropriate diagnostic tests should be performed to rule out other endocrinopathies in diabetic cats that are difficult to regulate.
Precautions: Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdosage can result in profound hypoglycemia and death. Progestogens, certain endocrinopathies and glucocorticoids can have an antagonistic effect on insulin activity. Progestogen and glucocorticoid use should be avoided.
Reproductive Safety: The safety and effectiveness of ProZinc insulin in breeding, pregnant, and lactating cats has not been evaluated.
Use in Kittens: The safety and effectiveness of ProZinc insulin in kittens has not been evaluated.
Adverse Reactions: Effectiveness Field Study
In a 45-day effectiveness field study, 176 cats received ProZinc insulin. Hypoglycemia (defined as a blood glucose value of < 50 mg/dL) occurred in 71 of the cats at various times throughout the study. Clinical signs of hypoglycemia were generally mild in nature (described as lethargic, sluggish, weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). In 17 cases, the veterinarian provided oral glucose supplementation or food as treatment. Most cases were not associated with clinical signs and received no treatment. One cat had a serious hypoglycemic event associated with stupor, lateral recumbency, hypothermia and seizures. All cases of hypoglycemia resolved with appropriate therapy and if needed, a dose reduction.
Three cats had injection site reactions which were described as either small, punctate, red lesions; lesions on neck; or palpable subcutaneous thickening. All injection site reactions resolved without cessation of therapy.
Four cats developed diabetic neuropathy during the study as evidenced by plantigrade stance. Three cats entered the study with plantigrade stance, one of which resolved by Day 45. Four cats were diagnosed with diabetic ketoacidosis during the study. Two were euthanized due to poor response to treatment. Five other cats were euthanized during the study, one of which had hypoglycemia. Four cats had received ProZinc insulin for less than a week and were euthanized due to worsening concurrent medical conditions.
The following additional clinical observations or diagnoses were reported in cats during the effectiveness field study: vomiting, lethargy, diarrhea, cystitis/hematuria, upper respiratory infection, dry coat, hair loss, ocular discharge, abnormal vocalization, black stool, and rapid breathing.
Extended Use Field Study
Cats that completed the effectiveness study were enrolled into an extended use field study. In this study, 145 cats received ProZinc insulin for up to an additional 136 days. Adverse reactions were similar to those reported during the 45-day effectiveness study and are listed in order of decreasing frequency: vomiting, hypoglycemia, anorexia/poor appetite, diarrhea, lethargy, cystitis/hematuria, and weakness. Twenty cats had signs consistent with hypoglycemia described as: sluggish, lethargic, unsteady, wobbly, seizures, trembling, or dazed. Most of these were treated by the owner or veterinarian with oral glucose supplementation or food; others received intravenous glucose. One cat had a serious hypoglycemic event associated with seizures and blindness. The cat fully recovered after supportive therapy and finished the study. All cases of hypoglycemia resolved with appropriate therapy and if needed, a dose reduction.
Fourteen cats died or were euthanized during the extended use study. In two cases, continued use of insulin despite anorexia and signs of hypoglycemia contributed to the deaths. In one case, the owner decided not to continue therapy after a presumed episode of hypoglycemia. The rest were due to concurrent medical conditions or worsening of the diabetes mellitus.
To report suspected adverse reactions, or to obtain a copy of the Material Safety Data Sheet (MSDS), call 1-866-638-2226.
Information for Cat Owners: Please refer to the Cat Owner Information Sheet for more information about ProZinc insulin. ProZinc insulin, like other insulin products, is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the associated clinical signs. Potential adverse reactions include: hypoglycemia, insulin antagonism/resistance, rapid insulin metabolism, insulin-induced hyperglycemia (Somogyi Effect), and local or systemic reactions. The most common adverse reaction observed is hypoglycemia. Signs may include: weakness, depression, behavioral changes, muscle twitching, and anxiety. In severe cases of hypoglycemia, seizures and coma can occur.
Hypoglycemia can be fatal if an affected cat does not receive prompt treatment. Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. The attending veterinarian should evaluate other adverse reactions on a case-by-case basis to determine if an adjustment in therapy is appropriate, or if alternative therapy should be considered.
Effectiveness: A total of 187 client-owned cats were enrolled in a 45-day field study, with 176 receiving ProZinc insulin. One hundred and fifty-one cats were included in the effectiveness analysis. The patients included various purebred and mixed breed cats ranging in age from 3 to 19 years and in weight from 4.6 to 20.8 pounds. Of the cats included in the effectiveness analysis, 101 were castrated males, 49 were spayed females, and 1 was an intact female.
Cats were started on ProZinc insulin at a dose of 0.1-0.3 IU/lb (0.2-0.7 IU/kg) twice daily. Cats were evaluated at 7, 14, 30, and 45 days after initiation of therapy and the dose was adjusted based on clinical signs and results of 9-hour blood glucose curves on Days 7, 14, and 30.
Effectiveness was based on successful control of diabetes which was defined as improvement in at least one blood glucose variable (glucose curve mean, nadir, or fructosamine) and at least one clinical sign (polyuria, polydipsia, or body weight). Based on this definition, 115 of 151 cases (76.2%) were considered successful. Blood glucose curve means decreased from 415.3 mg/dL on Day 0 to 203.2 mg/dL by Day 45 and the mean blood glucose nadir decreased from 407.9 mg/dL on Day 0 to 142.4 mg/dL on Day 45. Mean fructosamine values decreased from 505.9 �mol/L on Day 0 to 380.7 �mol/L on Day 45.
Cats that completed the effectiveness study were enrolled in an extended use field study. The mean fructosamine value was 342.0 �mol/L after a total of 181 days of ProZinc therapy.
How Supplied: ProZinc insulin is supplied as a sterile injectable suspension in 10 mL multidose vials. Each mL of ProZinc product contains 40 IU recombinant human insulin.
Storage Conditions: Store in an upright position under refrigeration at 36-46�F (2-8�C). Do not freeze. Protect from light.
Manufactured for: Boehringer Ingelheim Vetmedica, Inc., St. Joseph, MO 64506 U.S.A.
Manufactured by: Alcami Carolinas Corporation, Charleston, SC 29405
ProZinc� is a registered trademark of Boehringer Ingelheim Vetmedica, Inc.
� 2016 Boehringer Ingelheim Vetmedica, Inc. All Rights Reserved.
449901-02
Revised 06/2016
CPN: 1028175.2
