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Rx Item-Carboplatin 600mg 10Mg/ml Vial 60ml Ppx By Teva Pharma

Item No.: RX502346 NDC No.703423901 UPC No.:307034239018 NDC No. 00703-4239-81 UPC/GTIN No. 3-07034-23901-8 307034-239018 MPN No. 423981 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, HBRAND: CARBOPLATIN NDC: 00703-4239-01,703423901 UPC: 3-07034-23901-8,307034239018 Teva Pharmaceuticals USAOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Carboplatin 600mg 10Mg/ml Vial 60ml Ppx By Teva Pharma

$79.30$53.14

Item No.: RX502346 NDC No.703423901 UPC No.:307034239018 NDC No. 00703-4239-81 UPC/GTIN No. 3-07034-23901-8 307034-239018 MPN No. 423981 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, Hospital, Lic.Lab, Naturalist, Naturopath, NP, Optometrist, Pharmacist, PA, Physical Therapist, Podiatrist, Research Co., Uni., VA, Vet & Wholesalers In Scope Of their Practice Can Order RX Item. RX Item No. RX502346 Carboplatin 10Mg/ml Vial 60ml By Teva Pharma Item No. 502346 NDC No. 00703423981 UPC

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CARBOPLATIN- carboplatin injection, solution
Hospira Worldwide, Inc.

Rx onlyHospira logo

WARNING

Carboplatin Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.



Bone marrow suppression is dose related and may be severe, resulting in infection and/or bleeding. Anemia may be cumulative and may require transfusion support. Vomiting is another frequent drug-related side effect.

Anaphylactic-like reactions to Carboplatin Injection have been reported and may occur within minutes of Carboplatin Injection administration. Epinephrine, corticosteroids, and antihistamines have been employed to alleviate symptoms.

DESCRIPTION

Carboplatin Injection is supplied as a sterile, aqueous solution available in 50 mg/5 mL, 150 mg/15 mL, 450 mg/45 mL or 600 mg/60 mL multi-dose vials containing 10 mg/mL of carboplatin for administration by intravenous infusion. Each mL contains 10 mg carboplatin and Water for Injection, USP.

Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. The chemical name for carboplatin is platinum, diammine [1,1-cyclobutane-dicarboxylato(2-)-0,0�]-,(SP-4-2), and has the following structural formula:

structural formula carboplatin
(click image for full-size original)
Carboplatin is a crystalline powder with the molecular formula of C6 H12 N2 04 Pt and a molecular weight of 371.25. It is soluble in water at a rate of approximately 14 mg/mL, and the pH of a 1% solution is 5-7. It is virtually insoluble in ethanol, acetone, and dimethylacetamide.

CLINICAL PHARMACOLOGY

Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA -protein cross-links. This effect is apparently cell-cycle nonspecific. The aquation of carboplatin, which is thought to produce the active species, occurs at a slower rate than in the case of cisplatin. Despite this difference, it appears that both carboplatin and cisplatin induce equal numbers of drug-DNA cross-links, causing equivalent lesions and biological effects. The differences in potencies for carboplatin and cisplatin appear to be directly related to the difference in aquation rates.

In patients with creatinine clearances of about 60 mL/min or greater, plasma levels of intact carboplatin decay in a biphasic manner after a 30-minute intravenous infusion of 300 to 500 mg/m2 of Carboplatin Injection. The initial plasma half-life (alpha) was found to be 1.1 to 2 hours (N=6), and the postdistribution plasma half-life (beta) was found to be 2.6 to 5.9 hours (N=6). The total body clearance, apparent volume of distribution and mean residence time for carboplatin are 4.4 L/hour, 16 L and 3.5 hours, respectively. The Cmax values and areas under the plasma concentration vs. time curves from 0 to infinity (AUC inf) increase linearly with dose, although the increase was slightly more than dose proportional. Carboplatin, therefore, exhibits linear pharmacokinetics over the dosing range studied (300 � 500 mg/m2).

Carboplatin is not bound to plasma proteins. No significant quantities of protein-free, ultrafilterable platinum-containing species other than carboplatin are present in plasma. However, platinum from carboplatin becomes irreversibly bound to plasma proteins and is slowly eliminated with a minimum halflife of 5 days.

The major route of elimination of carboplatin is renal excretion. Patients with creatinine clearances of approximately 60 mL/min or greater excrete 65% of the dose in the urine within 12 hours and 71% of the dose within 24 hours. All of the platinum in the 24-hour urine is present as carboplatin. Only 3% to 5% of the administered platinum is excreted in the urine between 24 and 96 hours. There are insufficient data to determine whether biliary excretion occurs.

In patients with creatinine clearances below 60 mL/min the total body and renal clearances of carboplatin decrease as the creatinine clearance decreases. Carboplatin Injection dosages should therefore be reduced in these patients (see DOSAGE AND ADMINISTRATION).

The primary determinant of Carboplatin Injection clearance is glomerular filtration rate (GFR) and this parameter of renal function is often decreased in elderly patients. Dosing formulas incorporating estimates of GFR (see DOSAGE AND ADMINISTRATION) to provide predictable Carboplatin Injection plasma AUCs should be used in elderly patients to minimize the risk of toxicity.

Item No.: RX502346 NDC No.703423901 UPC No.:307034239018 NDC No. 00703-4239-81 UPC/GTIN No. 3-07034-23901-8 307034-239018 MPN No. 423981 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, H
Rx Item-Carboplatin 600mg 10Mg/ml Vial 6
Item No.: RX502346 NDC No.703423901 UPC No.:307034239018 NDC No. 00703-4239-81 UPC/GTIN No. 3-07034-23901-8 307034-239018 MPN No. 423981 Only Lic.-Physician, Pharmacy, Dentist, Drug Mfg, Dist., Gov, H

BRAND: CARBOPLATIN NDC: 00703-4239-01,703423901 UPC: 3-07034-23901-8,307034239018 Teva Pharmaceuticals USA
Carboplatin 600Mg 10Mg/Ml Vial 60Ml PPX
BRAND: CARBOPLATIN NDC: 00703-4239-01,703423901 UPC: 3-07034-23901-8,307034239018 Teva Pharmaceuticals USA

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
CARBOPLATIN INTRAVEN VIAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.