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Rx Item-Myobloc Inj 2500Un 0.5Ml Vial DS By Soltice Neuroscience(ASD )

Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104  MPN 71010BRAND: MYOBLOC NDC:     10454-0710-10,10454071010 UPC: 3-59730-42031-3,359730420313 Biotest PharmaOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104  MPN 71010

Rx Item-Myobloc Inj 2500Un 0.5Ml Vial DS By Soltice Neuroscience(ASD )

$348.60$332.00

Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104 MPN 71010 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.RX10454-0710-10 MYOBLOC INJ 2500UN 0.5ML VL by SOLTICE NEUROSCIENCE(ASD) Item No. 10454-0710-10 NDC No.1

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MYOBLOC- rimabotulinumtoxinb injection, solution
Solstice Neurosciences, LLC
Distant Spread of Toxin Effect

Postmarketing reports indicate that the effects of MYOBLOC and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including spasticity in children and adults, and in approved indications, cases of spread of effect have occurred at doses comparable to those used to treat cervical dystonia and at lower doses.
DESCRIPTION

Myobloc� (rimabotulinumtoxinB) injection is a sterile liquid formulation of a purified neurotoxin that acts at the neuromuscular junction to produce flaccid paralysis. The neurotoxin is produced by fermentation of the bacterium Clostridium botulinum type B (Bean strain) and exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.

MYOBLOC is provided as a clear and colorless to light-yellow sterile injectable solution in 3.5-mL glass vials. Each single-use vial of formulated MYOBLOC contains 5,000 Units of botulinum toxin type B per milliliter in 0.05% human serum albumin, 0.01 M sodium succinate, and 0.1 M sodium chloride at approximately pH 5.6.

One unit of MYOBLOC corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice. The method for performing the assay is specific to Solstice Neurosciences" manufacture of MYOBLOC. Due to differences in specific details such as the vehicle, dilution scheme and laboratory protocols for various mouse LD50 assays, units of biological activity of MYOBLOC cannot be compared to or converted into units of any other botulinum toxin or any toxin assessed with any other specific assay method. Therefore, differences in species sensitivities to different botulinum neurotoxin serotypes preclude extrapolation of animal dose-activity relationships to human dose estimates. The specific activity of MYOBLOC ranges between 70 to 130 Units/ng.
CLINICAL PHARMACOLOGY

The seven serologically distinct botulinum neurotoxins, designated A through G, share a common structural organization consisting of one Heavy Chain and one Light Chain polypeptide linked by a single disulfide bond. These toxins inhibit acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release. MYOBLOC specifically has been demonstrated to cleave synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release.

Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104  MPN 71010
10454-0710-10
Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104 MPN 71010

BRAND: MYOBLOC NDC:     10454-0710-10,10454071010 UPC: 3-59730-42031-3,359730420313 Biotest Pharma
Myobloc Inj 2500Un 0.5Ml Vial By Soltice
BRAND: MYOBLOC NDC: 10454-0710-10,10454071010 UPC: 3-59730-42031-3,359730420313 Biotest Pharma

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
HEPATITIS B IMMUNE GLOBUL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104  MPN 71010
10454-0710-10
Item No.:RX10454-0711-10 NDC No.10454-0710-10 10454-710-10 1045471010 10454071010 UPC/GTIN No.3-10454-71010-4 310454-710104 310454710104 MPN 71010