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Rx Item-Olmesartan-Amlodipine Generic Azor 5-20Mg Tab 30 By Sun Pharma

NDC No. 57664-0772-83 UPC/GTIN No. 3-57664-77283-6 MPN 077283BRAND: AZOR NDC: 57664-0772-83,57664077283 UPC: 3-57664-77283-6,357664772836 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Olmesartan-Amlodipine Generic Azor 5-20Mg Tab 30 By Sun Pharma

$90.75$103.71

item No.:RX57664-0772-83 NDC No.57664077283 UPC No.:357664772836 NDC No. 57664-0772-83 UPC/GTIN No. 3-57664-77283-6 MPN 077283 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx57664-0772-83 Olmesartan-Amlodipine Generic Azor 5-20MG TAB 30 by Sun Pharma Item No 57664-0772-83 NDC No. 57664077283 UPC

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AZOR- amlodipine besylate and olmesartan medoxomil tablet, film coated
Daiichi Sankyo, Inc.

WARNING: FETAL TOXICITY
When pregnancy is detected, discontinue Azor as soon as possible .
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetu


Azor? (amlodipine and olmesartan medoxomil) tablets
DESCRIPTION
Azor provided as tablet for oral administration, is combination of the calcium channel blocker (CCB) amlodipine besylate and the angiotensin II receptor blocker (ARB) olmesartan medoxomil.
The amlodipine besylate component of Azor is chemically described as 3-ethyl-5-methyl (?)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is C20 H25 CIN2 O5 ?C6 H6 O3 S.
Olmesartan medoxomil, prodrug, is hydrolyzed to olmesartan during absorption from the gastrointestinal tract.
The olmesartan medoxomil component of Azor is chemically described as 2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p- (o- 1H -tetrazol-5-ylphenyl)benzyl]imidazole-5-carboxylate, cyclic 2,3-carbonate. Its empirical formula is C29 H30 N6 O6 .

Mechanism of Action
Azor. Azor is combination of two antihypertensive drugs: dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker), amlodipine besylate, and an angiotensin II receptor blocker, olmesartan medoxomil. The amlodipine component of Azor inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, and the olmesartan medoxomil component of Azor blocks the vasoconstrictor effects of angiotensin II.

Azor contains amlodipine besylate, white to off-white crystalline powder, and olmesartan medoxomil, white to light yellowish-white powder or crystalline powder. The molecular weights of amlodipine besylate and olmesartan medoxomil are 567.1 and 558.59, respectively. Amlodipine besylate is slightly soluble in water and sparingly soluble in ethanol. Olmesartan medoxomil is practically insoluble in water and sparingly soluble in methanol.
INDICATIONS AND USAGE
Azor is indicated for the treatment of hypertension, alone or with other antihypertensive agents to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Azor.
DOSAGE AND ADMINISTRATION
General Considerations
The side effects of olmesartan medoxomil are generally rare and apparently independent of dose. Those of amlodipine are generally dose-dependent (mostly edema).
Maximum antihypertensive effects are attained within weeks after change in dose.
Azor may be taken with or without food.
Azor may be administered with other antihypertensive agents.
Dosage may be increased after weeks. The maximum recommended dose of Azor is 10/40 mg.
DOSAGE FORMS AND STRENGTHS
Azor tablets are formulated for oral administration in the following strength combinations:


5/20
5/40
10/20
10/40
Amlodipine equivalent (mg)
5
5
10
10
Olmesartan medoxomil (mg)
20
40
20
40
4 CONTRAINDICATIONS
Do not co-administer aliskiren with Azor in patients with diabetes [See Drug Interactions ].
5 WARNINGS AND PRECAUTIONS
5.1 Fetal toxicity
Pregnancy Category D
Hypotension in Volume- or Salt-Depleted Patients
Vasodilation
Patients with Severe Obstructive Coronary Artery Disease
Patients with Congestive Heart Failure
Patients with Impaired Renal Function
Olmesartan medoxomil. Changes in renal function may be anticipated in susceptible individuals treated with olmesartan medoxomil as consequence of inhibiting the renin-angiotensin-aldosterone system.
Patients with Hepatic Impairment
Sprue-like Enteropathy
Electrolyte and Metabolic Imbalances
Pregnancy
Pregnancy Category D
The antihypertensive effects of olmesartan medoxomil have been demonstrated in seven placebo-controlled studies at doses ranging from 2.5 mg to 80 mg for to 12 weeks, each showing statistically significant reductions in peak and trough blood pressure. total of 2693 patients (2145 olmesartan medoxomil; 548 placebo) with essential hypertension were studied. The blood pressure lowering effect was maintained throughout the 24-hour period with olmesartan medoxomil once daily, with trough-to-peak ratios for systolic and diastolic response between 60% and 80%.
16 HOW SUPPLIED/STORAGE AND HANDLING
Azor tablets contain amlodipine besylate at dose equivalent to or 10 mg amlodipine and olmesartan medoxomil in the strengths described below.
Azor tablets are differentiated by tablet color/size and are debossed with an individual product tablet code on one side.


NDC No. 57664-0772-83 UPC/GTIN No. 3-57664-77283-6 MPN 077283
RX ITEM-Olmesartan-Amlodipine Generic Az
NDC No. 57664-0772-83 UPC/GTIN No. 3-57664-77283-6 MPN 077283

BRAND: AZOR NDC: 57664-0772-83,57664077283 UPC: 3-57664-77283-6,357664772836
Olmesartan-Amlodipine Generic Azor 5-20M
BRAND: AZOR NDC: 57664-0772-83,57664077283 UPC: 3-57664-77283-6,357664772836

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
Click above for Brand.
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.