RX ITEM-Zonisamide 100Mg Cap 100 By Camber Pharma

ZONEGRAN- zonisamide capsule
Eisai Inc.
DESCRIPTION
ZONEGRAN� (zonisamide) is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The active ingredient is zonisamide, 1,2-benzisoxazole-3-methanesulfonamide. The empirical formula is C8 H8 N2 O3 S with a molecular weight of 212.23. Zonisamide is a white powder, pKa = 10.2, and is moderately soluble in water (0.80 mg/mL) and 0.1 N HCl (0.50 mg/mL).
Mechanism of Action :
The precise mechanism(s) by which zonisamide exerts its antiseizure effect is unknown. Zonisamide demonstrated anticonvulsant activity in several experimental models. In animals, zonisamide was effective against tonic extension seizures induced by maximal electroshock but ineffective against clonic seizures induced by subcutaneous pentylenetetrazol. Zonisamide raised the threshold for generalized seizures in the kindled rat model and reduced the duration of cortical focal seizures induced by electrical stimulation of the visual cortex in cats. Furthermore, zonisamide suppressed both interictal spikes and the secondarily generalized seizures produced by cortical application of tungstic acid gel in rats or by cortical freezing in cats. The relevance of these models to human epilepsy is unknown.
INDICATIONS AND USAGE
ZONEGRAN is indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.
CONTRAINDICATIONS
ZONEGRAN is contraindicated in patients who have demonstrated hypersensitivity to sulfonamides or zonisamide.
WARNINGS
Potentially Fatal Reactions to Sulfonamides: Fatalities have occurred, although rarely, as a result of severe reactions to sulfonamides ( zonisamide is a sulfonamide) including Stevens-Johnson syndrome, toxic epidermalnecrolysis , fulminant hepatic necrosis, agranulocytosis , aplastic anemia, and other blood dyscrasias . Such reactions may occur when a sulfonamide is readministered irrespective of the route of administration. If signs of hypersensitivity or other serious reactions occur, discontinue zonisamide immediately. Specific experience with sulfonamide-type adverse reaction to zonisamide is described below.
DOSAGE AND ADMINISTRATION
ZONEGRAN (zonisamide) is recommended as adjunctive therapy for the treatment of partial seizures in adults. Safety and efficacy in pediatric patients below the age of 16 have not been established. ZONEGRAN should be administered once or twice daily, using 25 mg or 100 mg capsules. ZONEGRAN is given orally and can be taken with or without food. Capsules should be swallowed whole.

RX ITEM-Zonisamide 100Mg Cap 100 By Camb
NDC 31722-0228-01 UPC/GTIN No.3-37122-22801-5 Mfg.Part No.22801

Zonisamide 100Mg Cap 100 By Camber Pharm
BRAND: ZONISAMIDE NDC: 31722-0228-01,31722022801 UPC: 3-37122-22801-5,337122228015 Camber Pharmaceuticals

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