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RX ITEM-Zofran 8Mg Tab 100 By Glaxosmithkline Rx

NDC 00173-0447-02 UPC/GTIN No.3-01730-44702-9 Mfg.Part No.44702BRAND: ZOFRAN NDC: 00173-0447-02,173044702 UPC: 3-01730-44702-9,301730447029 Glaxosmithkline/RxOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Zofran 8Mg Tab 100 By Glaxosmithkline Rx

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Item No.: RX450338 NDC No.173044702 UPC No.:301730447029 NDC No.00173-0447-02 UPC/GTIN No.3-01730-44702-9 MPN 44702 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx450338 Zofran 8mg Tab 100 by Glaxosmithkline/Rx Item No.3450338 NDC No.00173044702 UPC No.301730447029 Other Name Zofran Therapeutic C

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ZOFRAN- ondansetron hydrochloride solution
ZOFRAN ODT- ondansetron tablet, orally disintegrating
ZOFRAN- ondansetron hydrochloride tablet, film coated
GlaxoSmithKline LLC


1 INDICATIONS AND USAGE
ZOFRAN� is indicated for the prevention of nausea and vomiting associated with:

highly emetogenic cancer chemotherapy, including cisplatin greater than or equal to 50 mg/m2.

initial and repeat courses of moderately emetogenic cancer chemotherapy.

radiotherapy in patients receiving either total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
ZOFRAN is also indicated for the prevention of postoperative nausea and/or vomiting.
2 DOSAGE AND ADMINISTRATION
2.1 Dosage
The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2, respectively.
Corresponding doses of ZOFRAN tablets, ZOFRAN ODT� orally disintegrating tablets and ZOFRAN oral solution may be used interchangeably.
DOSAGE FORMS AND STRENGTHS
ZOFRAN tablets are oval, film-coated tablets engraved with �Zofran" on one side and are available in the following strengths:

4 mg � white tablet with �4" engraved on the other side.

8 mg � yellow tablet with �8" engraved on the other side.
ZOFRAN ODT orally disintegrating tablets are white, round, and plano-convex tablets available in the following strengths:

4 mg � debossed with �Z4" on one side.

8 mg � debossed with �Z8" on one side.
ZOFRAN oral solution, 4 mg/5 mL, is a clear, colorless to light yellow liquid with a characteristic strawberry odor available in a 50-mL bottle.
4 CONTRAINDICATIONS
ZOFRAN is contraindicated in patients:
1.
known to have hypersensitivity (e.g., anaphylaxis) to ondansetron or any of the components of the formulation [see Adverse Reactions (6.2)].
2.
receiving concomitant apomorphine due to the risk of profound hypotension and loss of consciousness.
DESCRIPTION
The active ingredient in ZOFRAN tablets and ZOFRAN oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5?HT3receptor type. Chemically it is (�) 1, 2, 3, 9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one, monohydrochloride, dihydrate
Mechanism of Action
Ondansetron is a selective 5?HT3 receptor antagonist. While its mechanism of action has not been fully characterized, ondansetron is not a dopamine?receptor antagonist. Serotonin receptors of the 5?HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron�s antiemetic action is mediated centrally, peripherally, or in both sites. However, cytotoxic chemotherapy appears to be associated with release of serotonin from the enterochromaffin cells of the small intestine. In humans, urinary 5?hydroxyindoleacetic acid (5?HIAA) excretion increases after cisplatin administration in parallel with the onset of emesis. The released serotonin may stimulate the vagal afferents through the 5?HT3 receptors and initiate the vomiting reflex.


NDC 00173-0447-02 UPC/GTIN No.3-01730-44702-9 Mfg.Part No.44702
RX ITEM-Zofran 8Mg Tab 100 By Glaxosmith
NDC 00173-0447-02 UPC/GTIN No.3-01730-44702-9 Mfg.Part No.44702

BRAND: ZOFRAN NDC: 00173-0447-02,173044702 UPC: 3-01730-44702-9,301730447029 Glaxosmithkline/Rx
Zofran 8Mg Tab 100 By Glaxosmithkline Rx
BRAND: ZOFRAN NDC: 00173-0447-02,173044702 UPC: 3-01730-44702-9,301730447029 Glaxosmithkline/Rx

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.