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RX ITEM-Zinecard 500Mg Vial By Pfizer Pharma Inj

NDC 00013-8727-89 UPC/GTIN No.3-00138-72789-4 Mfg.Part No.872789BRAND: ZINECARD NDC: 00013-8727-89,13872789 UPC: 3-00138-72789-4,300138727894 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Zinecard 500Mg Vial By Pfizer Pharma Inj

$563.72$541.17

item No.:RX022756 NDC No.13872789 UPC No.:300138727894 NDC No.00013-8727-89 UPC/GTIN No.3-00138-72789-4 MPN 872789 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No.Rx022756 Zinecard 500mg Vial by Pfizer Pharm/Inj Item No.3022756 NDC No.00013872789 UPC No.300138727894 Other Name Zinecard,Dexrazoxane I

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ZINECARD- dexrazoxane hydrochloride injection, powder, lyophilized, for solution
Pharmacia and Upjohn Company


INDICATIONS AND USAGE
ZINECARD is indicated for reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m2 and who will continue to receive doxorubicin therapy to maintain tumor control. Do not use with the initiation of doxorubicin therapy [see Warnings and Precautions (5.2)].
2 DOSAGE AND ADMINISTRATION
2.1 Recommended Dose
Administer ZINECARD Injection via intravenous infusion over 15 minutes. DO NOT ADMINISTER VIA AN INTRAVENOUS PUSH.
The recommended dosage ratio of ZINECARD to doxorubicin is 10:1 (e.g., 500 mg/m2 ZINECARD to 50 mg/m2 doxorubicin). Do not administer doxorubicin before ZINECARD. Administer doxorubicin within 30 minutes after the completion of ZINECARD infusion.
Preparation and Administration
Preparation and Handling of Infusion Solution
Reconstitute ZINECARD with Sterile Water for Injection, USP. Reconstitute with 25 mL for a ZINECARD 250 mg vial and 50 mL for a ZINECARD 500 mg vial to give a concentration of 10 mg/mL. Dilute the reconstituted solution further with Lactated Ringer's Injection, USP to a concentration of 1.3 to 3.0 mg/mL in intravenous infusion bags for intravenous infusion
DOSAGE FORMS AND STRENGTHS
ZINECARD (dexrazoxane for injection) is available in 250 mg or 500 mg single dose vials as sterile, pyrogen-free lyophilizates.
DESCRIPTION
ZINECARD (dexrazoxane for injection), a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate intended for intravenous administration.
Chemically, dexrazoxane is (S)-4,4′-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione.
Mechanism of Action
The mechanism by which ZINECARD exerts its cytoprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane is converted intracellularly to a ring-opened chelating agent that interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy.
HOW SUPPLIED/STORAGE AND HANDLING
ZINECARD (dexrazoxane for injection) is available in the following strengths as sterile, pyrogen-free lyophilizates.
NDC 0013-8717-62
250 mg single dose vial with a red flip-top seal, packaged in single vial packs.
NDC 0013-8727-89
500 mg single dose vial with a blue flip-top seal, packaged in single vial packs.
Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].


NDC 00013-8727-89 UPC/GTIN No.3-00138-72789-4 Mfg.Part No.872789
RX ITEM-Zinecard 500Mg Vial By Pfizer Ph
NDC 00013-8727-89 UPC/GTIN No.3-00138-72789-4 Mfg.Part No.872789

BRAND: ZINECARD NDC: 00013-8727-89,13872789 UPC: 3-00138-72789-4,300138727894
Zinecard 500Mg Vial By Pfizer Pharma Inj
BRAND: ZINECARD NDC: 00013-8727-89,13872789 UPC: 3-00138-72789-4,300138727894

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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