RX ITEM-Vasopressi N+ 20 Unit Ml Vial 25X1Ml By Fresenius Kabi USA

PITRESSIN- vasopressin injection
JHP Pharmaceuticals LLC

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DESCRIPTION

Pitressin (Vasopressin Injection, USP) Synthetic is a sterile, aqueous solution of synthetic vasopressin (8-Arginine vasopressin) of the posterior pituitary gland. It is substantially free from the oxytocic principle and is standardized to contain 20 USP units/mL. The solution contains 0.5% Chlorobutanol (chloroform derivative) as a preservative. The acidity of the solution is adjusted with acetic acid.

CLINICAL PHARMACOLOGY



The antidiuretic action of vasopressin is ascribed to increasing reabsorption of water by the renal tubules.

Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of all parts of the vascular bed, especially the capillaries, small arterioles, and venules with less effect on the smooth musculature of the large veins. The direct effect on the contractile elements is neither antagonized by adrenergic blocking agents nor prevented by vascular denervation.

Following subcutaneous or intramuscular administration of vasopressin injection, the duration of antidiuretic activity is variable but effects are usually maintained for 2 to 8 hours.

The majority of a dose of vasopressin is metabolized and rapidly destroyed in the liver and kidneys. Vasopressin has a plasma half-life of about 10 to 20 minutes. Approximately 5% of a subcutaneous dose of vasopressin is excreted in urine unchanged after 4 hours.

CONTRAINDICATION

Anaphylaxis or hypersensitivity to the drug or its components.

Pitressin Indications and Usage

Pitressin is indicated for prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus.
DOSAGE AND ADMINISTRATION

Pitressin may be administered subcutaneously or intramuscularly.

Ten units of Pitressin (0.5 mL) will usually elicit full physiologic response in adult patients; 5 units will be adequate in many cases. Pitressin should be given intramuscularly at 3- or 4-hour intervals as needed. The dosage should be proportionately reduced for pediatric patients. (For an additional discussion of dosage, consult the sections below.)

When determining the dose of Pitressin for a given case, the following should be kept in mind.

It is particularly desirable to give a dose not much larger than is just sufficient to elicit the desired physiologic response. Excessive doses may cause undesirable side effects-blanching of the skin, abdominal cramps, nausea-which, though not serious, may be alarming to the patient. Spontaneous recovery from such side effects occurs in a few minutes. It has been found that one or two glasses of water given at the time Pitressin is administered reduce such symptoms.

RX ITEM-Vasopressi N+ 20 Unit Ml Vial 25
NDC 63323-0302-09 UPC/GTIN No.3-63323-30209-2 Mfg.Part No.30209

Vasopressi N+ 20 Unit Ml Vial 25X1Ml By
BRAND: VASOPRESSIN NDC: 63323-0302-09,63323030209 UPC: 3-63323-30209-2,363323302092 Fresenius Kabi USA Llc

VASOPRESSIN INJECTION VIA
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