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Rx Item-Valsartan-HCTZ 320/12.5Mg Tab 500 By Lupin Pharma

NDC 68180-0101-02 UPC/GTIN No.3-68180-10102-4 Mfg.Part No.10102BRAND: VALSARTAN-HCTZ NDC: 68180-0101-02,68180010102 UPC: 3-68180-10102-4,368180101024 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Valsartan-HCTZ 320/12.5Mg Tab 500 By Lupin Pharma

$2707.39$3094.16

Item No.:RX286885/A, Item No. RX286885, 286885, NDC No.: 68180-0101-02, 68180-101-02, 6818010102, 68180010102, 0101-02, 010102 UPC No. 3-68180-10102-4, 368180-101024, 368180101024, Rx Item-Valsartan-HCTZ 320/12.5Mg Tab 500 By Lupin Pharma Only Physician, Pharmacy Or Licensed Facility Can purchase this RX Item Brand/Generic: , Drug Category: Angiotensin Receptor Blockers With ThiazideDrug Class: 24320800 Angiotensin Ii Receptor Antagonists
40282000 Thiazide Diuretics
24082420 Thiazide Diur

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DIOVAN HCT- valsartan and hydrochlorothiazide tablet, film coated
Novartis Pharmaceuticals Corporation

WARNING: FETAL TOXICITY

When pregnancy is detected, discontinue Diovan HCT as soon as possible. (5.1)
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (5.1)
1 INDICATIONS AND USAGE



Diovan HCT (valsartan and hydrochlorothiazide, USP) is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including hydrochlorothiazide and the ARB class to which valsartan principally belongs. There are no controlled trials demonstrating risk reduction with Diovan HCT.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).
DOSAGE AND ADMINISTRATION

2.1 General Considerations
The usual starting dose is Diovan HCT 160/12.5 mg once daily. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 320/25 tablet once daily as needed to control blood pressure [see Clinical Studies (14.2)]. Maximum antihypertensive effects are attained within 2 to 4 weeks after a change in dose.
DESCRIPTION

Diovan HCT (valsartan and hydrochlorothiazide, USP) is a combination of valsartan, an orally active, specific angiotensin II receptor blocker (ARB) acting on the AT1 receptor subtype, and hydrochlorothiazide, a diuretic.

Valsartan, a nonpeptide molecule, is chemically described as N -(1-oxopentyl)-N -[[2?-(1H -tetrazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-L-Valine. Its empirical formula is C24 H29 N5 O3 , its molecular weight is 435.5,
Valsartan is a white to practically white fine powder. It is soluble in ethanol and methanol and slightly soluble in water.

Hydrochlorothiazide USP is a white, or practically white, practically odorless, crystalline powder. It is slightly soluble in water; freely soluble in sodium hydroxide solution, in n -butylamine, and in dimethylformamide; sparingly soluble in methanol; and insoluble in ether, in chloroform, and in dilute mineral acids. Hydrochlorothiazide is chemically described as 6-chloro-3,4-dihydro-2H -1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.

Hydrochlorothiazide is a thiazide diuretic. Its empirical formula is C7 H8 ClN3 O4 S2 , its molecular weight is 297.73
Diovan HCT tablets are formulated for oral administration to contain valsartan and hydrochlorothiazide, USP 80/12.5 mg, 160/12.5 mg, 160/25 mg, 320/12.5 mg, and 320/25 mg. The inactive ingredients of the tablets are colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, iron oxides, magnesium stearate, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.

NDC 68180-0101-02 UPC/GTIN No.3-68180-10102-4 Mfg.Part No.10102
RX ITEM-Valsartan-HCTZ 320/12.5Mg Tab 50
NDC 68180-0101-02 UPC/GTIN No.3-68180-10102-4 Mfg.Part No.10102

BRAND: VALSARTAN-HCTZ NDC: 68180-0101-02,68180010102 UPC: 3-68180-10102-4,368180101024
Valsartan-HCTZ 320/12.5Mg Tab 500 By Lup
BRAND: VALSARTAN-HCTZ NDC: 68180-0101-02,68180010102 UPC: 3-68180-10102-4,368180101024

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