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Rx Item-Tobi Inhalation 300Mg/5Ml Amp 56X5Ml By Mylan Specialty

NDC 00078-0494-71 UPC/GTIN No.3-00780-49471-7 Mfg.Part No.49471 Tobi. Item No.:RX166546 NDC No.78049471 UPC No.:300780494717 NDC No.00078-0494-71 00078-494-71  0007849471 7849471  00078049471   UPC/GTBRAND: TOBI INH NDC: 00078-0494-71,78049471 UPC: 3-00780-49471-7,300780494717 Novartis Pharma CorpOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Tobi Inhalation 300Mg/5Ml Amp 56X5Ml By Mylan Specialty

$8805.37$8000.32

Tobramycin in 0.225% sod chlor INHALATION AMPUL-NEB 300 MG/5ML Item No.: RX166546 NDC No.78049471 UPC No.:300780494717 NDC No.00078-0494-71 00078-494-71 0007849471 7849471 00078049471 UPC/GTIN No.3-00780-49471-7 300780-49471 7 300780494717 MPN 49471 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item

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TOBI- tobramycin solution
Mylan Specialty Pharmaceuticals Corporation

DESCRIPTION

TOBI� is a tobramycin solution for inhalation. It is a sterile, clear, slightly yellow, non-pyrogenic, aqueous solution with the pH and salinity adjusted specifically for administration by a compressed air driven reusable nebulizer. The chemical formula for tobramycin is C18 H37 N5 O9 and the molecular weight is 467.52. Tobramycin is O -3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O -[2,6-diamino-2,3,6-trideoxy-α-D-ribo -hexopyranosyl-(1→6)]-2-deoxy-L-streptamine. The structural formula for tobramycin is:

TOBI tobramycin solution structural formula.
(click image for full-size original)


Each single-use 5 mL ampule contains 300 mg tobramycin and 11.25 mg sodium chloride in sterile water for injection. Sulfuric acid and sodium hydroxide are added to adjust the pH to 6.0. Nitrogen is used for sparging. All ingredients meet USP requirements. The formulation contains no preservatives.

CLINICAL PHARMACOLOGY

TOBI is specifically formulated for administration by inhalation. When inhaled, tobramycin is concentrated in the airways.

Pharmacokinetics
TOBI contains tobramycin, a cationic polar molecule that does not readily cross epithelial membranes.(1) The bioavailability of TOBI may vary because of individual differences in nebulizer performance and airway pathology.(2) Following administration of TOBI, tobramycin remains concentrated primarily in the airways.

Sputum Concentrations: Ten minutes after inhalation of the first 300-mg dose of TOBI, the average concentration of tobramycin was 1237 mcg/g (ranging from 35 to 7417 mcg/g) in sputum. Tobramycin does not accumulate in sputum; after 20 weeks of therapy with the TOBI regimen, the average concentration of tobramycin at ten minutes after inhalation was 1154 mcg/g (ranging from 39 to 8085 mcg/g) in sputum. High variability of tobramycin concentration in sputum was observed. Two hours after inhalation, sputum concentrations declined to approximately 14% of tobramycin levels at ten minutes after inhalation.

Serum Concentrations: The average serum concentration of tobramycin one hour after inhalation of a single 300-mg dose of TOBI by cystic fibrosis patients was 0.95 mcg/mL. After 20 weeks of therapy on the TOBI regimen, the average serum tobramycin concentration one hour after dosing was 1.05 mcg/mL.

Elimination: The elimination half-life of tobramycin from serum is approximately 2 hours after intravenous (IV) administration. Assuming tobramycin absorbed following inhalation behaves similarly to tobramycin following IV administration, systemically absorbed tobramycin is eliminated principally by glomerular filtration. Unabsorbed tobramycin, following TOBI administration, is probably eliminated primarily in expectorated sputum.

Microbiology
Tobramycin is an aminoglycoside antibiotic produced by Streptomyces tenebrarius.(1) It acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, progressive disruption of the cell envelope, and eventual cell death.(3)

Tobramycin has in vitro activity against a wide range of gram-negative organisms including Pseudomonas aeruginosa. It is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.

NDC 00078-0494-71 UPC/GTIN No.3-00780-49471-7 Mfg.Part No.49471 Tobi. Item No.:RX166546 NDC No.78049471 UPC No.:300780494717 NDC No.00078-0494-71 00078-494-71  0007849471 7849471  00078049471   UPC/GT
RX ITEM-Tobi Inhalation 300Mg/5Ml Amp 56
NDC 00078-0494-71 UPC/GTIN No.3-00780-49471-7 Mfg.Part No.49471 Tobi. Item No.:RX166546 NDC No.78049471 UPC No.:300780494717 NDC No.00078-0494-71 00078-494-71 0007849471 7849471 00078049471 UPC/GT

BRAND: TOBI INH NDC: 00078-0494-71,78049471 UPC: 3-00780-49471-7,300780494717 Novartis Pharma Corp
Tobi Inhalation 300Mg/5Ml Amp 56X5Ml By
BRAND: TOBI INH NDC: 00078-0494-71,78049471 UPC: 3-00780-49471-7,300780494717 Novartis Pharma Corp

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
TOBRAMYCIN IN 0.225% NACL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.