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Rx Item-Timolol O-S 0.25% Drops 10Ml By Sandoz Falcon Pharma

Timolol O-S 0.25% Drops 10Ml By Sandoz Item No.: RX002295 NDC No.61314022610 61314-226-10 61314022610  UPC No.:361314226105 NDC No. 61314-0226-10 UPC/GTIN No. 3-61314-22610-5 361314226105 361314-22610NDC 61314-0226-10 UPC/GTIN No.3-61314-22610-5 Mfg.Part No.22610Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.BRAND: TIMOLOL NDC: 61314-0226-10,61314022610 UPC: 3-61314-22610-5,361314226105

Rx Item-Timolol O-S 0.25% Drops 10Ml By Sandoz Falcon Pharma

$27.75$19.99

Item No.: RX002295 NDC No.61314022610 61314-226-10 61314022610 UPC No.:361314226105 NDC No. 61314-0226-10 UPC/GTIN No. 3-61314-22610-5 361314226105 361314-226105 MPN 22610 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx002295 Timolol O-S 0.25% drops 10ml by Sandoz/Falcon Pharma Item No. 3002295

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TIMOLOL GFS- timolol maleate solution, gel forming, extended release
Sandoz Inc

1 INDICATIONS AND USAGE

Timolol GFS 0.25% and 0.5% are indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

2 DOSAGE AND ADMINISTRATION



Instill one drop of Timolol GFS (either 0.25% or 0.5%) in the affected eye(s) once daily. It may be used alone or in combination with other intraocular pressure lowering medications.

3 DOSAGE FORMS AND STRENGTHS

5 mL size bottle filled with 2.5 mL or 5 mL of 0.25% or 0.5% sterile ophthalmic gel forming solution

4 CONTRAINDICATIONS

Timolol GFS is contraindicated in patients with:

� bronchial asthma

� history of bronchial asthma

� severe chronic obstructive pulmonary disease

� sinus bradycardia

� second or third degree atrioventricular block

� overt cardiac failure

� cardiogenic shock

� hypersensitivity to any component of this product.
DESCRIPTION

Timolol GFS (timolol maleate ophthalmic gel forming solution) is a non-selective beta-adrenergic receptor inhibitor. Its chemical name is (-)-1-(tert -butylamino)-3-[(4-morpholino-1,2,5-thia diazol-3-yl)oxy]-2-propanol maleate (1:1) (salt).

Timolol maleate possesses an asymmetric carbon atom in its structure and is provided at the levo-isomer. The nominal optical rotation of timolol maleate is:

[?] 25� in 0.1N HCl (C=5%) = -12.2�

405 nm

Its molecular formula is C13 H24 N4 O3 S�C4 H4 O4
Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol. Timolol GFS is a colorless to nearly colorless, slightly opalescent, and slightly viscous, is supplied as a sterile, isotonic, buffered, aqueous topical ophthalmic solution of timolol maleate in two dosage strengths. Timolol GFS has a pH of approximately 6.9 and an osmolality of approximately 290 mOsmol/kg. Each mL of Timolol GFS 0.25% contains 2.5 mg of timolol (3.4 mg of timolol maleate). Each mL of Timolol GFS 0.5% contains 5.0 mg of timolol (6.8 mg of timolol maleate). Inactive ingredients: xanthan gum, tromethamine, boric acid, mannitol, polysorbate-80, and purified water. Preservative: benzododecinium bromide 0.012%.

Xanthan gum is a purified high molecular weight polysaccharide gum produced from the fermentation by bacterium Xanthomonas campestris. An aqueous solution of xanthan gum, in the presence of tear protein (lysozyme), forms a gel. Upon contact with the precorneal tear film, Timolol GFS forms a gel that is subsequently removed by the flow of tears.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor inhibitor that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Timolol GFS, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. The precise mechanism of the ocular hypotensive action of Timolol GFS is not clearly established at this time. Tonography and fluorophotometry studies of Timolol GFS in man suggest that its predominant action may be related to reduced aqueous formation. However, in some studies, a slight increase in outflow facility was also observed. Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients with heart disease. In patients with severe impairment of myocardial function beta-adrenergic receptor inhibitors may inhibit the stimulatory effect of the sympathetic nervous system necessary to maintain adequate cardiac function. Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activities. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous.
Pharmacodynamics
Because in some patients the intraocular pressure-lowering response to Timolol GFS may require a few weeks to stabilize, evaluation should include a determination of intraocular pressure after approximately 4 weeks of treatment with Timolol GFS. If the patient's intraocular pressure is still not at a satisfactory level on this regimen, concomitant therapy can be considered.

Timolol O-S 0.25% Drops 10Ml By Sandoz Item No.: RX002295 NDC No.61314022610 61314-226-10 61314022610  UPC No.:361314226105 NDC No. 61314-0226-10 UPC/GTIN No. 3-61314-22610-5 361314226105 361314-22610
Timolol O-S 0.25% Sandoz
Timolol O-S 0.25% Drops 10Ml By Sandoz Item No.: RX002295 NDC No.61314022610 61314-226-10 61314022610 UPC No.:361314226105 NDC No. 61314-0226-10 UPC/GTIN No. 3-61314-22610-5 361314226105 361314-22610

NDC 61314-0226-10 UPC/GTIN No.3-61314-22610-5 Mfg.Part No.22610
RX ITEM-Timolol O-S 0.25% Drops 10Ml By
NDC 61314-0226-10 UPC/GTIN No.3-61314-22610-5 Mfg.Part No.22610

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
Clik above for TIMOLOL MALEATE OPHTHALMI
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

BRAND: TIMOLOL NDC: 61314-0226-10,61314022610 UPC: 3-61314-22610-5,361314226105
Timolol O-S 0.25% Drops 10Ml By Sandoz F
BRAND: TIMOLOL NDC: 61314-0226-10,61314022610 UPC: 3-61314-22610-5,361314226105