Please email us at [email protected] with our item No, NDC#, UPC# or the product link if you have any quetions. We are located in Oceanside, California. Search over 110,000 items by Name, Item No., NDC, UPC (without dashes) or by Mfg.Name. Please note, Prescription items can only be ordered by a Drug Manufacturer, Wholesaler, Hospital, Governmental Medical Facility, VA, Pharmacy, Physician, Physician Assistant, Nurse Practitioner, Dentist, Podiatrist, Optometrist, Veterinarian, Naturopath, Licensed Lab, Physical Therapist & Pharmacist in their scope of practice. No order will ship, unless you you have provided us the Medical License (and DEA Lic. in case of controlled drug) and we had verified that. Rx items can only be shipped to AZ, AR, CA, CT, DE, FL, GA, GU, HI, IL, KS, KY, LA, ME, MA, MI, NJ, NY, PA, PR, TX, TN, VA, WA, WI and WV. If you are an International Physician or Pharmacist, please contact us before ordering.


Menu

RX ITEM-Tiagabine Hcl 2Mg Tab 30 By Teva Pharma

NDC 55253-0600-30 UPC/GTIN No.3-55253-60030-0 Mfg.Part No.60030BRAND: TIAGABINE NDC: 55253-0600-30,55253060030 UPC: 3-55253-60030-0,355253600300 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Tiagabine Hcl 2Mg Tab 30 By Teva Pharma

$0.00

Item No.: RX289041/a NDC No.55253060030 UPC No.:355253600300 NDC No. New 00093-5030-56 55253-0600-30 UPC/GTIN No. 3-55253-60030-0 MPN 60030 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx289041 Tiagabine Hcl 2mg Tab 30 by Teva Pharma Item No. 3289041 NDC No. new 00093503056 55253060030 UPC No. 3

Have a question?

  Out of stock, please email us with the item number or product link at [email protected] for the quantity available, current pricing and eligibility to purchase.

TIAGABINE HYDROCHLORIDE - tiagabine hydrochloride tablet, film coated
Sun Pharmaceutical Industries Limited
DESCRIPTION

Tiagabine hydrochloride, USP is an antiepilepsy drug available as 2 mg and 4 mg tablets for oral administration. Its chemical name is (-)-(R)-1-[4,4-Bis(3- methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, its molecular formula is C20 H25 NO2 S2 HCl, and its molecular weight is 412. Tiagabine hydrochloride is a white to off-white, odorless, crystalline powder. It is insoluble in heptane, sparingly soluble in water, and soluble in aqueous base.
nactive Ingredients
Tiagabine hydrochloride tablets contain the following inactive ingredients: Hydrogenated vegetable oil, anhydrous lactose, butylated hydroxyanisole, pregelatinized maize starch, colloidal silicon dioxide, talc, crospovidone, titanium dioxide, hypromellose, polyethylene glycol.
In addition, individual tablets contain:
2 mg tablets: FD&C Yellow No. 6 and polysorbate 80.4 mg tablets: Lactose monohydrate and D&C Yellow No. 10.
CLINICAL PHARMACOLOGY

Mechanism of Action

The precise mechanism by which tiagabine exerts its antiseizure effect is unknown, although it is believed to be related to its ability, documented in in vitro experiments, to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. These experiments have shown that tiagabine binds to recognition sites associated with the GABA uptake carrier. It is thought that, by this action, tiagabine blocks GABA uptake into presynaptic neurons, permitting more GABA to be available for receptor binding on the surfaces of post-synaptic cells. Inhibition of GABA uptake has been shown for synaptosomes, neuronal cell cultures, and glial cell cultures. In rat-derived hippocampal slices, tiagabine has been shown to prolong GABA-mediated inhibitory post-synaptic potentials. Tiagabine increases the amount of GABA available in the extracellular space of the globus pallidus, ventral palladum, and substantia nigra in rats at the ED50 and ED85 doses for inhibition of pentylenetetrazol (PTZ)-induced tonic seizures. This suggests that tiagabine prevents the propagation of neural impulses that contribute to seizures by a GABA-ergic action.
Tiagabine has shown efficacy in several animal models of seizures. It is effective against the tonic phase of subcutaneous PTZ-induced seizures in mice and rats, seizures induced by the proconvulsant DMCM in mice, audiogenic seizures in genetically epilepsy-prone rats (GEPR), and amygdala-kindled seizures in rats. Tiagabine has little efficacy against maximal electroshock seizures in rats and is only partially effective against subcutaneous PTZ-induced clonic seizures in mice, picrotoxin-induced tonic seizures in the mouse, bicuculline-induced seizures in the rat, and photic seizures in photosensitive baboons. Tiagabine produces a biphasic dose-response curve against PTZ- and DMCM-induced convulsions, with attenuated effectiveness at higher doses.Based on in vitro binding studies, tiagabine does not significantly inhibit the uptake of dopamine, norepinephrine, serotonin, glutamate, or choline and shows little or no binding to dopamine D1 and D2, muscarinic, serotonin 5HT1A , 5HT2 , and 5HT3 , beta-1 and 2 adrenergic, alpha-1 and alpha-2 adrenergic, histamine H2 and H3, adenosine A1 and A2 , opiate � and K1 , NMDA glutamate, and GABAA receptors at 100 �M. It also lacks significant affinity for sodium or calcium channels. Tiagabine binds to histamine H1 , serotonin 5HT1B , benzodiazepine, and chloride channel receptors at concentrations 20 to 400 times those inhibiting the uptake of GABA.
INDICATIONS AND USAGE

Tiagabine hydrochloride tablets are indicated as adjunctive therapy in adults and children 12 years and older in the treatment of partial seizures.
CONTRAINDICATIONS

Tiagabine hydrochloride tablets are contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
WARNINGS

Seizures in Patients Without Epilepsy: Postmarketing reports have shown that tiagabine hydrochloride use has been associated with new onset seizures and status epilepticus in patients without epilepsy. Dose may be an important predisposing factor in the development of seizures, although seizures have been reported in patients taking daily doses of tiagabine hydrochloride as low as 4 mg/day. In most cases, patients were using concomitant medications (antidepressants, antipsychotics, stimulants, narcotics) that are thought to lower the seizure threshold. Some seizures occurred near the time of a dose increase, even after periods of prior stable dosing.
DOSAGE AND ADMINISTRATION

General:
The blood level of tiagabine obtained after a given dose depends on whether the patient also is receiving a drug that induces the metabolism of tiagabine. The presence of an inducer means that the attained blood level will be substantially reduced. Dosing should take the presence of concomitant medications into account.
Tiagabine hydrochloride tablets are recommended as adjunctive therapy for the treatment of partial seizures in patients 12 years and older.
The following dosing recommendations apply to all patients taking tiagabine hydrochloride tablets:

Tiagabine hydrochloride tablets are given orally and should be taken with food.
Do not use a loading dose of tiagabine hydrochloride tablets
Dose titration: Rapid escalation and/or large dose increments of tiagabine hydrochloride tablets should not be used.
Missed dose(s): If the patient forgets to take the prescribed dose of tiagabine hydrochloride tablets at the scheduled time, the patient should not attempt to make up for the missed dose by increasing the next dose. If a patient has missed multiple doses, patient should refer back to his or her physician for possible re-titration as clinically indicated.
Dosage adjustment of tiagabine hydrochloride tablets should be considered whenever a change in patient's enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.
Medication Guide

Tiagabine Hydrochloride(tye-AG-a-been hye-droe-KLOR-ide)Tablets
Read this Medication Guide before you start taking tiagabine hydrochloride tablets and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

What is the most important information I should know about tiagabine hydrochloride tablets?
Do not stop taking tiagabine hydrochloride tablets without first talking to your healthcare provider.
Stopping tiagabine hydrochloride tablets suddenly can cause serious problems.
Tiagabine hydrochloride tablets can cause serious side effects, including:

Tiagabine hydrochloride tablets may cause seizures in people who do not have epilepsy. If you do not have a seizure disorder and you take tiagabine hydrochloride tablets, you may have a seizure or seizures that do not stop (status epilepticus). Call your healthcare provider right away if you have a seizure and you are not taking tiagabine hydrochloride tablets for epilepsy.
Like other antiepileptic drugs, tiagabine hydrochloride tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

� thoughts about suicide or dying � new or worse irritability
� attempts to commit suicide � acting aggressive, being angry, or violent
� new or worse depression � acting on dangerous impulses
� new or worse anxiety � an extreme increase in activity and panic attacks
� feeling agitated or restless talking (mania)
� trouble sleeping (insomnia) � other unusual changes in behavior or mood
Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.
How can I watch for early symptoms of suicidal thoughts and actions?

Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
Keep all follow-up visits with your healthcare provider as scheduled.
Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop tiagabine hydrochloride tablets without first talking to a healthcare provider.

Stopping tiagabine hydrochloride tablets suddenly can cause serious problems. If you have epilepsy and stop a seizure medicine suddenly, you may have more frequent seizures or seizures that will not stop (status epilepticus).

What are tiagabine hydrochloride tablets?
Tiagabine hydrochloride tablets are a prescription medicine used with other medicines to treat partial seizures in adults and children age 12 and older.
Who should not take tiagabine hydrochloride tablets?
Do not take tiagabine hydrochloride tablets if you are allergic to tiagabine hydrochloride or any of the other ingredients in tiagabine hydrochloride tablets. See the end of this Medication Guide for a complete list of ingredients in tiagabine hydrochloride tablets.

What should I tell my healthcare provider before taking tiagabine hydrochloride tablets?
Before taking tiagabine hydrochloride tablets, tell your healthcare provider if you:

have or have had depression, mood problems, or suicidal thoughts or behavior
have liver problems
have a history of seizures that do not stop (status epilepticus)
have any other medical conditions
are pregnant or plan to become pregnant. It is not known if tiagabine hydrochloride tablets can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking tiagabine hydrochloride tablets. You and your healthcare provider will decide if you should take tiagabine hydrochloride tablets while you are pregnant.
If you become pregnant while taking tiagabine hydrochloride tablets, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. The purpose of this registry is to collect information about the safety of antiepileptic medicines during pregnancy. You can enroll in this registry by calling 1-888-233-2334.
are breastfeeding or plan to breastfeed. It is not known if tiagabine passes into breast milk or if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take tiagabine hydrochloride tablets.

Tell your healthcare provider about all the medicines you take , including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking tiagabine hydrochloride tablets with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.
Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine. Always tell your healthcare provider if there are any changes in any other medicines that you take.
How should I take tiagabine hydrochloride tablets?

Take tiagabine hydrochloride tablets exactly as your healthcare provider tells you.
Your healthcare provider may change your dose.
Tiagabine hydrochloride tablets should be taken with food.
Do not stop taking tiagabine hydrochloride tablets without talking to your healthcare provider. Stopping tiagabine hydrochloride tablets suddenly can increase your chances of having a seizure or cause seizures that will not stop.
If you miss a dose of tiagabine hydrochloride tablets, do not take 2 doses of tiagabine hydrochloride tablets at the same time. Contact your healthcare provider if you miss more than one dose.

If you take too many tiagabine hydrochloride tablets, call your healthcare provider or local Poison Control Center right away.
What should I avoid while taking tiagabine hydrochloride tablets?

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking tiagabine hydrochloride tablets without first talking to your healthcare provider. Taking tiagabine hydrochloride tablets with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse.
Do not drive, operate heavy machinery, or do other dangerous activities until you know how tiagabine hydrochloride tablets affect you. Tiagabine hydrochloride tablets can slow your thinking and motor skills.

What are possible side effects of tiagabine hydrochloride tablets?
See "What is the most important information I should know about tiagabine hydrochloride tablets?"

Tiagabine hydrochloride tablets may cause other serious side effects including:

s eizures that can happen more often or become worse
trouble concentrating, problems with speech and language, feeling confused, feeling sleepy and tired, and problems thinking
weakness all over your body
eye and vision problems
serious rash

Call your healthcare provider right away if you have any of the serious side effects listed above.
The most common side effects of tiagabine hydrochloride tablets include:

dizziness
lack of energy
drowsiness
nausea
nervousness
tremor
stomach pain
abnormal thinking
difficulty with concentration or attention

These are not all the possible side effects of tiagabine hydrochloride tablets. For more information, ask your healthcare provider or pharmacist. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store tiagabine hydrochloride tablets?

Store tiagabine hydrochloride tablets at 20� to 25�C (68� to 77�F); excursions permitted between 15� and 30�C (59� and 86�F).
Keep tiagabine hydrochloride tablets out of light
Keep tiagabine hydrochloride tablets dry

Keep tiagabine hydrochloride tablets and all medicines out of the reach of children.

General Information about Tiagabine Hydrochloride Tablets
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use tiagabine hydrochloride tablets for a condition for which it was not prescribed. Do not give tiagabine hydrochloride tablets to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about tiagabine hydrochloride tablets. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about tiagabine hydrochloride tablets that is written for health professionals.
For more information, call 1-800-818-4555.
What are the ingredients in tiagabine hydrochloride tablets?

Active Ingredient: tiagabine hydrochloride, USP

NDC 55253-0600-30 UPC/GTIN No.3-55253-60030-0 Mfg.Part No.60030
RX ITEM-Tiagabine Hcl 2Mg Tab 30 By Teva
NDC 55253-0600-30 UPC/GTIN No.3-55253-60030-0 Mfg.Part No.60030

BRAND: TIAGABINE NDC: 55253-0600-30,55253060030 UPC: 3-55253-60030-0,355253600300
Tiagabine Hcl 2Mg Tab 30 By Teva Pharma
BRAND: TIAGABINE NDC: 55253-0600-30,55253060030 UPC: 3-55253-60030-0,355253600300

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
Click above for Gabiril
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.