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RX ITEM-Tambocor 100Mg Tab 100 By Valeant Pharma

NDC 99207-0181-10 UPC/GTIN No.3-99207-18110-1 Mfg.Part No.18110BRAND: TAMBOCOR NDC: 99207-0181-10,99207018110 UPC: 3-99207-18110-1,399207181101 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Tambocor 100Mg Tab 100 By Valeant Pharma

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Item No.: RX167429 NDC No.99207018110 UPC No.:399207181101 NDC No. 99207-0181-10 UPC/GTIN No. 3-99207-18110-1 MPN 18110 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx167429 Tambocor 100mg Tab 100 by Valeant Pharma Item No. 3167429 NDC No. 99207018110 UPC No. 399207181101 Other Name Tambocor, Fl

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TAMBOCOR- flecainide acetate tablet
Medicis Pharmaceutical Corp

DESCRIPTION

TAMBOCOR� (flecainide acetate) is an antiarrhythmic drug available in tablets of 50, 100, or 150 mg for oral administration.

Flecainide acetate is benzamide, N-(2-piperidinyl-methyl) -2,5-bis (2,2,2-trifluoroethoxy)-monoacetate
Flecainide acetate is a white crystalline substance with a pKa of 9.3. It has an aqueous solubility of 48.4 mg/mL at 37�C.

TAMBOCOR tablets also contain: croscarmellose sodium, hydrogenated vegetable oil, magnesium stearate, microcrystalline cellulose and starch.

CLINICAL PHARMACOLOGY

TAMBOCOR has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
Tambocor Indications and Usage

In patients without structural heart disease, TAMBOCOR is indicated for the prevention of


paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disabling symptoms

paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms
TAMBOCOR is also indicated for the prevention of


documented ventricular arrhythmias, such as sustained ventricular tachycardia (sustained VT), that in the judgment of the physician are life-threatening.
Use of TAMBOCOR for the treatment of sustained VT, like other antiarrhythmics, should be initiated in the hospital. The use of TAMBOCOR is not recommended in patients with less severe ventricular arrhythmias even if the patients are symptomatic.

Because of the proarrhythmic effects of TAMBOCOR, its use should be reserved for patients in whom, in the opinion of the physician, the benefits of treatment outweigh the risks.

TAMBOCOR should not be used in patients with recent myocardial infarction. (See Boxed Warnings.)

Use of TAMBOCOR in chronic atrial fibrillation has not been adequately studied and is not recommended. (See Boxed Warnings.)

As is the case for other antiarrhythmic agents, there is no evidence from controlled trials that the use of TAMBOCOR favorably affects survival or the incidence of sudden death.
CONTRAINDICATIONS

TAMBOCOR is contraindicated in patients with pre-existing second- or third-degree AV block, or with right bundle branch block when associated with a left hemiblock (bifascicular block), unless a pacemaker is present to sustain the cardiac rhythm should complete heart block occur. TAMBOCOR is also contraindicated in the presence of cardiogenic shock or known hypersensitivity to the drug.

WARNINGS

Mortality. TAMBOCOR was included in the National Heart Lung and Blood Institute�s Cardiac Arrhythmia Suppression Trial (CAST), a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction more than six days but less than two years previously. An excessive mortality or non-fatal cardiac arrest rate was seen in patients treated with TAMBOCOR compared with that seen in patients assigned to a carefully matched placebo-treated group. This rate was 16/315 (5.1%) for TAMBOCOR and 7/309 (2.3%) for the matched placebo. The average duration of treatment with TAMBOCOR in this study was ten months. The applicability of the CAST results to other populations (e.g., those without recent myocardial infarction) is uncertain, but at present, it is prudent to consider the risks of Class IC agents (including TAMBOCOR), coupled with the lack of any evidence of improved survival, generally unacceptable in patients without life-threatening ventricular arrhythmias, even if the patients are experiencing unpleasant, but not life-threatening, symptoms or signs.

Ventricular Pro-arrhythmic Effects in Patients with Atrial Fibrillation/Flutter. A review of the world literature revealed reports of 568 patients treated with oral TAMBOCOR for paroxysmal atrial fibrillation/flutter (PAF). Ventricular tachycardia was experienced in 0.4% (2/568) of these patients. Of 19 patients in the literature with chronic atrial fibrillation (CAF), 10.5% (2) experienced VT or VF. FLECAINIDE IS NOT RECOMMENDED FOR USE IN PATIENTS WITH CHRONIC ATRIAL FIBRILLATION. Case reports of ventricular proarrhythmic effects in patients treated with TAMBOCOR for atrial fibrillation/flutter have included increased PVCs, VT, ventricular fibrillation (VF), and death.

As with other Class I agents, patients treated with TAMBOCOR for atrial flutter have been reported with 1:1 atrioventricular conduction due to slowing the atrial rate. A paradoxical increase in the ventricular rate also may occur in patients with atrial fibrillation who receive TAMBOCOR. Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication.
DOSAGE AND ADMINISTRATION

For patients with sustained VT, no matter what their cardiac status, TAMBOCOR, like other antiarrhythmics, should be initiated in-hospital with rhythm monitoring.

Flecainide has a long half-life (12 to 27 hours in patients). Steady-state plasma levels, in patients with normal renal and hepatic function, may not be achieved until the patient has received 3 to 5 days of therapy at a given dose. Therefore, increases in dosage should be made no more frequently than once every four days , since during the first 2 to 3 days of therapy the optimal effect of a given dose may not be achieved.

NDC 99207-0181-10 UPC/GTIN No.3-99207-18110-1 Mfg.Part No.18110
RX ITEM-Tambocor 100Mg Tab 100 By Valean
NDC 99207-0181-10 UPC/GTIN No.3-99207-18110-1 Mfg.Part No.18110

BRAND: TAMBOCOR NDC: 99207-0181-10,99207018110 UPC: 3-99207-18110-1,399207181101
Tambocor 100Mg Tab 100 By Valeant Pharma
BRAND: TAMBOCOR NDC: 99207-0181-10,99207018110 UPC: 3-99207-18110-1,399207181101

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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