Rx Item-Synercid I.V. 500Mg Vial 10 By Pfizer Pharma

SYNERCID- quinupristin and dalfopristin injection, powder, lyophilized, for solution
Pfizer Laboratories Div Pfizer Inc

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Synercid and other antibacterial drugs, Synercid should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Microbiology
The streptogramin components of Synercid , quinupristin and dalfopristin, are present in a ratio of 30 parts quinupristin to 70 parts dalfopristin. These two components act synergistically so that Synercid's microbiologic in vitro activity is greater than that of the components individually. Quinupristin's and dalfopristin's metabolites also contribute to the antimicrobial activity of Synercid. In vitro synergism of the major metabolites with the complementary parent compound has been demonstrated.

Mechanism of Action
The site of action of quinupristin and dalfopristin is the bacterial ribosome. Dalfopristin has been shown to inhibit the early phase of protein synthesis while quinupristin inhibits the late phase of protein synthesis. Synercid is bactericidal against isolates of methicillin-susceptible and methicillin-resistant staphylococci. The mode of action of Synercid differs from that of other classes of antibacterial agents such as �-lactams, aminoglycosides, glycopeptides, quinolones, macrolides, lincosamides and tetracyclines. Therefore, there is no cross resistance between Synercid and these agents when tested by the minimum inhibitory concentration (MIC) method.

Synercid� (quinupristin and dalfopristin powder for injection) I.V., a streptogramin antibacterial agent for intravenous administration, is a sterile lyophilized formulation of two semisynthetic pristinamycin derivatives, quinupristin (derived from pristinamycin I) and dalfopristin (derived from pristinamycin IIA) in the ratio of 30:70 (w/w).

DOSAGE AND ADMINISTRATION

Synercid should be administered by intravenous infusion in 5% Dextrose in Water solution over a 60-minute period. (See WARNINGS.) An infusion pump or device may be used to control the rate of infusion. If necessary, central venous access (e.g., PICC) can be used to administer Synercid to decrease the incidence of venous irritation. The recommended dosage for the treatment of complicated skin and skin structure infections is 7.5 mg/kg q12h. The minimum recommended treatment duration for complicated skin and skin structure infections is seven days.

RX ITEM-Synercid I.V. 500Mg Vial 10 By P
NDC 61570-0260-10 UPC/GTIN No.3-61570-26010-3 Mfg.Part No.26010 vial , off-white Powder is off-white to pale yellow QUINUPRISTIN/DALFOPRISTIN

Synercid I.V. 500Mg Vial 10 By Pfizer Ph
BRAND: SYNERCID NDC: 61570-0260-10,61570026010 UPC: 3-61570-26010-3,361570260103 Pfizer Pharmaceutical

QUINUPRISTIN/DALFOPRISTIN
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