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RX ITEM-Sulfasalazine 500Mg Tab 100 By Greenstone Limited

Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.NDC 59762-0104-01 UPC/GTIN No.3-59762-01041-4 Mfg.Part No.10401BRAND: SULFASALAZINE NDC: 59762-0104-01,59762010401 UPC: 3-59762-01041-4,359762010414 Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005

RX ITEM-Sulfasalazine 500Mg Tab 100 By Greenstone Limited

$34.25$27.99

Item No.: RX916066 916066 NDC No. 59762-5000-05 59762500005 5976250005 59762-5000-5 UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005-2 359762500052 359762500052 MPN 50005 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx879054 Sulfasalazine 500mg Tab 100 by Greenstone Limi

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AZULFIDINE- sulfasalazine tablet
Pharmacia and Upjohn Company
DESCRIPTION
AZULFIDINE Tablets contain sulfasalazine, 500 mg, for oral administration.
Therapeutic Classification: Anti-inflammatory agent.
Chemical Designation: 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid.
Chemical Structure:

Molecular Formula: C18 H14 N4 O5 S
CLINICAL PHARMACOLOGY
Pharmacodynamics
The mode of action of sulfasalazine (SSZ) or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of SSZ, SP, and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety.
Pharmacokinetics
In vivo studies have indicated that the absolute bioavailability of orally administered SSZ is less than 15% for parent drug. In the intestine, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. Of the two species, SP is relatively well absorbed from the intestine and highly metabolized, while 5-ASA is much less well absorbed.
Absorption
Following oral administration of g of SSZ to healthy males, less than 15% of dose of SSZ is absorbed as parent drug. Detectable serum concentrations of SSZ have been found in healthy subjects within 90 minutes after the ingestion. Maximum concentrations of SSZ occur between and 12 hours post-ingestion, with the mean peak concentration g/mL) occurring at hours.
In comparison, peak plasma levels of both SP and 5-ASA occur approximately 10 hours after dosing. This longer time to peak is indicative of gastrointestinal transit to the lower intestine where bacteria mediated metabolism occurs. SP apparently is well absorbed from the colon with an estimated bioavailability of 60%. In this same study, 5-ASA is much less well absorbed from the gastrointestinal tract with an estimated bioavailability of from 10 to 30%.
Distribution
Following intravenous injection, the calculated volume of distribution (Vdss) for SSZ was 7.5 1.6 L. SSZ is highly bound to albumin (>99.3%) while SP is only about 70% bound to albumin. Acetylsulfapyridine (AcSP), the principal metabolite of SP, is approximately 90% bound to plasma proteins.
Metabolism
As mentioned above, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. Approximately 15% of dose of SSZ is absorbed as parent and is metabolized to some extent in the liver to the same two species. The observed plasma half-life for intravenous sulfasalazine is 7.6 3.4 hours. The primary route of metabolism of SP is via acetylation to form AcSP. The rate of metabolism of SP to AcSP is dependent upon acetylator phenotype. In fast acetylators, the mean plasma half-life of SP is 10.4 hours while in slow acetylators, it is 14.8 hours. SP can also be metabolized to 5-hydroxy-sulfapyridine (SPOH) and N-acetyl-5-hydroxy-sulfapyridine. 5-ASA is primarily metabolized in both the liver and intestine to N-acetyl-5-aminosalicylic acid via non-acetylation phenotype dependent route. Due to low plasma levels produced by 5-ASA after oral administration, reliable estimates of plasma half-life are not possible.
Excretion
Absorbed SP and 5-ASA and their metabolites are primarily eliminated in the urine either as free metabolites or as glucuronide conjugates. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. The calculated clearance of SSZ following intravenous administration was L/hr. Renal clearance was estimated to account for 37% of total clearance.
Special Populations
Elderly
Elderly patients with rheumatoid arthritis showed prolonged plasma half-life for SSZ, SP, and their metabolites. The clinical impact of this is unknown.
Pediatric
Small studies have been reported in the literature in children down to the age of years with ulcerative colitis and inflammatory bowel disease. In these populations, relative to adults, the pharmacokinetics of SSZ and SP correlated poorly with either age or dose.
Acetylator Status
The metabolism of SP to AcSP is mediated by polymorphic enzymes such that two distinct populations of slow and fast metabolizers exist. Approximately 60% of the Caucasian population can be classified as belonging to the slow acetylator phenotype. These subjects will display prolonged plasma half-life for SP (14.8 hours vs 10.4 hours) and an accumulation of higher plasma levels of SP than fast acetylators. The clinical implication of this is unclear; however, in small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed higher incidence of adverse events.
Gender
Gender appears not to have an effect on either the rate or the pattern of metabolites of SSZ, SP, or 5-ASA.
Azulfidine Indications and USAge
AZULFIDINE Tablets are indicated:
a)
in the treatment of mild to moderate ulcerative colitis, and as adjunctive therapy in severe ulcerative colitis; and
b)
for the prolongation of the remission period between acute attacks of ulcerative colitis.
CONTRAINDICATIONS
AZULFIDINE Tablets are contraindicated in:
Patients with intestinal or urinary obstruction,
Patients with porphyria as sulfonamides have been reported to precipitate an acute attack,
Patients hypersensitive to sulfasalazine, its metabolites, sulfonamides, or salicylates
PRECAUTIONS
General
AZULFIDINE Tablets should be given with caution to patients with severe allergy or bronchial asthma. Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation. Patients with glucose-6 phosphate dehydrogenase deficiency should be observed closely for signs of hemolytic anemia. This reaction is frequently dose related. If toxic or hypersensitivity reactions occur, the drug should be discontinued immediately.
Drug Interactions
Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine.
Drug/Laboratory Test Interactions
Several reports of possible interference with measurements, by liquid chromatography, of urinary normetanephrine causing false-positive test result have been observed in patients exposed to sulfasalazine or its metabolite, mesalamine/mesalazine.
Adverse Reactions to Azulfidine
Blood dyscrasias:
Hypersensitivity reactions:
Gastrointestinal reactions:
Rentral nervous system reactions
Renal reactions:
DOSAGE AND ADMINISTRATION
The dosage of AZULFIDINE Tablets should be adjusted to each individual?s response and tolerance.
Initial Therapy
Adults: to g daily in evenly divided doses with dosage intervals not exceeding eight hours. In some cases, it is advisable to initiate therapy with smaller dosage, e.g., to g daily, to reduce possible gastrointestinal intolerance. If daily doses exceeding g are required to achieve desired effects, the increased risk of toxicity should be kept in mind.
Children, six years of age and older: 40 to 60 mg/kg body weight in each 24-hour period, divided into to doses.
Maintenance Therapy
Adults: g daily.
Children, six years of age and older: 30 mg/kg body weight in each 24-hour period, divided into doses.

Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005
Sulfasalazine 500Mg Tab 100 By
Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05 59762500005 5976250005 59762-5000-5 UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005

Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005
Sulfasalazine 500Mg Tab 100 By
Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05 59762500005 5976250005 59762-5000-5 UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
Click above for Azulfidine
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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NDC 59762-0104-01 UPC/GTIN No.3-59762-01041-4 Mfg.Part No.10401
RX ITEM-Sulfasalazine 500Mg Tab 100 By G
NDC 59762-0104-01 UPC/GTIN No.3-59762-01041-4 Mfg.Part No.10401

BRAND: SULFASALAZINE NDC: 59762-0104-01,59762010401 UPC: 3-59762-01041-4,359762010414
Sulfasalazine 500Mg Tab 100 By Greenston
BRAND: SULFASALAZINE NDC: 59762-0104-01,59762010401 UPC: 3-59762-01041-4,359762010414

Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05  59762500005  5976250005  59762-5000-5  UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005
Sulfasalazine 500Mg Tab 100 By
Sulfasalazine 500Mg Tab 100 By Greenstone Limited Item No.: RX916066 NDC No. 59762-5000-05 59762500005 5976250005 59762-5000-5 UPC No.:359762010414 NDC No. 59762-0104-01 UPC/GTIN No. 3-59762-50005