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Rx Item-Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma

Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201

Rx Item-Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma

$28828.80$20203.11

Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma Item No.: RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201312 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx483487 Strensiq 28mg/0.7ml Vial 12 by Alexio

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For: Hypophosphatasia

Strensiq (asfotase alfa) is a tissue nonspecific alkaline phosphatase enzyme replacement therapy indicated for the treatment of patients with perinatal, infantile and juvenile-onset hypophosphatasia (HPP). STRENSIQ- asfotase alfa solution
Alexion Pharmaceuticals Inc.
1 INDICATIONS AND USAGE

STRENSIQ� is indicated for the treatment of patients with perinatal/infantile- and juvenile-onset hypophosphatasia (HPP).
2 DOSAGE AND ADMINISTRATION
2.1 Dosage for Perinatal/Infantile-Onset HPP

The recommended dosage regimen of STRENSIQ for the treatment of perinatal/infantile-onset HPP is 6 mg/kg per week administered subcutaneously as either:

2 mg/kg three times per week, or
1 mg/kg six times per week. Injection site reactions may limit the tolerability of the six times per week regimen [see Adverse Reactions (6.1)].

The dose of STRENSIQ may be increased for lack of efficacy (e.g., no improvement in respiratory status, growth, or radiographic findings) up to 9 mg/kg per week administered subcutaneously as 3 mg/kg three times per week.
2.2 Dosage for Juvenile-Onset HPP

The recommended dosage regimen of STRENSIQ for the treatment of juvenile-onset HPP is 6 mg/kg per week administered subcutaneously as either:

2 mg/kg three times per week, or
1 mg/kg six times per week. Injection site reactions may limit the tolerability of the six times per week regimen [see Adverse Reactions (6.1)].

2.3 Preparation and Weight-Based Dosing Tables

Caution: Do not use the 80 mg/0.8 mL vial of STRENSIQ in pediatric patients weighing less than 40 kg because the systemic exposure of asfotase alfa achieved with the 80 mg/0.8 mL vial (higher concentration) is lower than that achieved with the other strength vials (lower concentration). A lower exposure may not be adequate for this subgroup of patients [see Dosage Forms and Strengths (3), Clinical Pharmacology (12.3)].
DOSAGE FORMS AND STRENGTHS

STRENSIQ is supplied as a sterile, preservative-free, nonpyrogenic, clear, slightly opalescent or opalescent, colorless to slightly yellow aqueous solution; few small translucent or white particles may be present. The product is available as:

Injection: 18 mg/0.45 mL, 28 mg/0.7 mL, 40 mg/mL, or 80 mg/0.8 mL solution in single-use vials
DESCRIPTION

STRENSIQ is a formulation of asfotase alfa, which is a soluble glycoprotein composed of two identical polypeptide chains. Each chain contains 726 amino acids with a theoretical mass of 161 kDa. Each chain consists of the catalytic domain of human tissue non-specific alkaline phosphatase (TNSALP), the human immunoglobulin G1 Fc domain and a deca-aspartate peptide used as a bone targeting domain. The two polypeptide chains are covalently linked by two disulfide bonds.

STRENSIQ is a tissue nonspecific alkaline phosphatase produced by recombinant DNA technology in a Chinese hamster ovary cell line. TNSALP is a metallo-enzyme that catalyzes the hydrolysis of phosphomonoesters with release of inorganic phosphate and alcohol. Asfotase alfa has a specific activity of 620 to 1250 units/mg. One activity unit is defined as the amount of asfotase alfa required to form 1 �mol of p-nitrophenol from pNPP per minute at 37�C.

STRENSIQ (asfotase alfa) is a sterile, preservative-free, nonpyrogenic, clear, slightly opalescent or opalescent, colorless to slightly yellow, with few small translucent or white particles, aqueous solution for subcutaneous administration. STRENSIQ is supplied in glass single-use vials containing asfotase alfa; dibasic sodium phosphate, heptahydrate; monobasic sodium phosphate, monohydrate; and sodium chloride at a pH between 7.2 and 7.6.

Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201
RX ITEM-Strensiq 28Mg 0.7Ml Vial 12 By A
Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201

Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201
Strensiq asfotase alfa 28Mg
Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ASFOTASE ALFA SUB-Q VIAL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201
Strensiq asfotase alfa 28Mg
Strensiq asfotase alfa 28Mg 0.7Ml Vial 12 By Alexion Pharma item No.:RX483487 NDC No.25682001312 25682-013-12 2568201312 UPC No.:325682013125 NDC No. 25682-0013-12 UPC/GTIN No. 3-25682-01312-5 MPN 201