Please email us at [email protected] with our item No, NDC#, UPC# or the product link if you have any quetions. We are located in Oceanside, California. Search over 110,000 items by Name, Item No., NDC, UPC (without dashes) or by Mfg.Name. Please note, Prescription items can only be ordered by a Drug Manufacturer, Wholesaler, Hospital, Governmental Medical Facility, VA, Pharmacy, Physician, Physician Assistant, Nurse Practitioner, Dentist, Podiatrist, Optometrist, Veterinarian, Naturopath, Licensed Lab, Physical Therapist & Pharmacist in their scope of practice. No order will ship, unless you you have provided us the Medical License (and DEA Lic. in case of controlled drug) and we had verified that. Rx items can only be shipped to AZ, AR, CA, CT, DE, FL, GA, GU, HI, IL, KS, KY, LA, ME, MA, MI, NJ, NY, PA, PR, TX, TN, VA, WA, WI and WV. If you are an International Physician or Pharmacist, please contact us before ordering.


Menu

Rx Item-Stiolto olodaterol-tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim

Stiolto olodaterol and tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim item No.:RX410338 NDC No.00597-155-61 0059715561 597015561 UPC No.:305970155614 NDC No.00597-0155-61 UPC/GTIN No.3-05970-15BRAND: STIOLTO NDC: 00597-0155-61,597015561 UPC: 3-05970-15561-4,305970155614 Boehringer Ingelheim  Stiolto 2.5 2.5Mcg Inh by Boehringer IngelheimOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Stiolto olodaterol-tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim

$526.06$477.97

Stiolto olodaterol and tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim Item No.: RX410338 NDC No.00597-155-61 0059715561 597015561 UPC No.:305970155614 NDC No.00597-0155-61 UPC/GTIN No.3-05970-15561-4 305970155614 305970-155614 MPN 15561 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No.Rx410338

Have a question?

For: Chronic Obstructive Pulmonary Disease

Stiolto Respimat (olodaterol and tiotropium bromide) is a long-acting beta agonist (LABA) and long-acting muscarinic antagonist (LAMA) fixed-dose combination for the treatment of chronic obstructive pulmonary disease (COPD). STIOLTO RESPIMAT- tiotropium bromide monohydrate and olodaterol hydrochloride spray, metered
Boehringer Ingelheim Pharmaceuticals Inc.
WARNING: ASTHMA-RELATED DEATH

Long-acting beta2 -adrenergic agonists (LABA) such as olodaterol, one of the active ingredients in STIOLTO RESPIMAT, increase the risk of asthma-related death. Data from a large, placebo-controlled US study that compared the safety of another long-acting beta2 -adrenergic agonist (salmeterol) with placebo added to usual asthma therapy showed an increase in asthma-related deaths in patients receiving salmeterol. This finding with salmeterol is considered a class effect of all LABA, including olodaterol, one of the active ingredients in STIOLTO RESPIMAT. The safety and efficacy of STIOLTO RESPIMAT in patients with asthma have not been established. STIOLTO RESPIMAT is not indicated for the treatment of asthma [see Contraindications (4), Warnings and Precautions (5.1)].
1  INDICATIONS AND USAGE
1.1 Maintenance Treatment of COPD

STIOLTO RESPIMAT is a combination of tiotropium and olodaterol indicated for long-term, once-daily maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

Important Limitations of Use

STIOLTO RESPIMAT is not indicated to treat acute deteriorations of COPD [See Warnings and Precautions (5.2)].
STIOLTO RESPIMAT is not indicated to treat asthma. The safety and effectiveness of STIOLTO RESPIMAT in asthma have not been established.

2  DOSAGE AND ADMINISTRATION
2.1 Recommended Dosage

The recommended dose of STIOLTO RESPIMAT is two inhalations once-daily at the same time of the day. Do not use STIOLTO RESPIMAT more than two inhalations every 24 hours.
DOSAGE FORMS AND STRENGTHS

Inhalation Spray: STIOLTO RESPIMAT consists of a STIOLTO RESPIMAT inhaler and an aluminum cylinder (STIOLTO RESPIMAT cartridge) containing a combination of tiotropium bromide (as the monohydrate) and olodaterol (as the hydrochloride). The STIOLTO RESPIMAT cartridge is intended only for use with the STIOLTO RESPIMAT inhaler.

Each actuation from the STIOLTO RESPIMAT inhaler delivers 3.124 mcg tiotropium bromide monohydrate (equivalent to 2.5 mcg tiotropium) and 2.736 mcg olodaterol hydrochloride (equivalent to 2.5 mcg olodaterol) from the mouthpiece.

Two actuations equal one dose.
4  CONTRAINDICATIONS

All LABAs are contraindicated in patients with asthma without use of a long-term asthma control medication [see Warnings and Precautions (5.1)]. STIOLTO RESPIMAT is not indicated for the treatment of asthma.

STIOLTO RESPIMAT is contraindicated in patients with a hypersensitivity to tiotropium, ipratropium, olodaterol, or any component of this product [see Warnings and Precautions (5.4)].

In clinical trials and postmarketing experience with tiotropium, immediate hypersensitivity reactions, including angioedema (including swelling of the lips, tongue, or throat), itching, or rash have been reported. Hypersensitivity reactions were also reported in clinical trials with STIOLTO RESPIMAT.
DESCRIPTION

STIOLTO RESPIMAT is a combination of tiotropium, an anticholinergic, and olodaterol, a long-acting beta2 -adrenergic agonist (LABA).

The drug substance tiotropium bromide monohydrate is chemically described as (1α, 2�, 4�, 5α, 7�)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4 ] nonane bromide monohydrate. It is a synthetic, non-chiral, quaternary ammonium compound. Tiotropium bromide is a white or yellowish white powder. It is sparingly soluble in water and soluble in methanol.
CLINICAL PHARMACOLOGY
12.1 Mechanism of Action

STIOLTO RESPIMAT
STIOLTO RESPIMAT contains both tiotropium and olodaterol. The properties described below for the individual components apply to STIOLTO RESPIMAT. These drugs represent 2 different classes of medication (an anticholinergic and a beta-agonist) that have different effects on clinical and physiological indices.

Tiotropium
Tiotropium is a long-acting, muscarinic antagonist which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M1 to M5 . In the airways, it exhibits pharmacological effects through inhibition of M3 -receptors at the smooth muscle leading to bronchodilation. The competitive and reversible nature of antagonism was shown with human and animal origin receptors and isolated organ preparations. In preclinical in vitro as well as in vivo studies, prevention of methacholine-induced bronchoconstriction effects was dose-dependent and lasted longer than 24 hours. The bronchodilation following inhalation of tiotropium is predominantly a site-specific effect.

Olodaterol
Olodaterol is a long-acting beta2 -adrenergic agonist (LABA). The compound exerts its pharmacological effects by binding and activation of beta2 -adrenoceptors after topical administration by inhalation. Activation of these receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3', 5" adenosine monophosphate (cAMP). Elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells. In vitro studies have shown that olodaterol has 241-fold greater agonist activity at beta2 -adrenoceptors compared to beta1 -adrenoceptors and 2299-fold greater agonist activity compared to beta3 -adrenoceptors. The clinical significance of these findings is unknown.

Stiolto olodaterol and tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim item No.:RX410338 NDC No.00597-155-61 0059715561 597015561 UPC No.:305970155614 NDC No.00597-0155-61 UPC/GTIN No.3-05970-15
RX ITEM-Stiolto 2.5 2.5Mcg Inhaler By Bo
Stiolto olodaterol and tiotropium 2.5 2.5Mcg Inhaler By Boehringer Ingelheim item No.:RX410338 NDC No.00597-155-61 0059715561 597015561 UPC No.:305970155614 NDC No.00597-0155-61 UPC/GTIN No.3-05970-15

BRAND: STIOLTO NDC: 00597-0155-61,597015561 UPC: 3-05970-15561-4,305970155614 Boehringer Ingelheim  Stiolto 2.5 2.5Mcg Inh by Boehringer Ingelheim
Stiolto 2.5 2.5Mcg Inhaler By Boehringer
BRAND: STIOLTO NDC: 00597-0155-61,597015561 UPC: 3-05970-15561-4,305970155614 Boehringer Ingelheim Stiolto 2.5 2.5Mcg Inh by Boehringer Ingelheim

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
TIOTROPIUM BR/OLODATEROL
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
Buy More Save More!
Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.