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RX ITEM-Protamine Sul 10Mg/Ml Vial 25X5Ml By Fresenius Kabi USA

NDC 63323-0229-05 UPC/GTIN No.3-63323-22905-4 Mfg.Part No.22905BRAND: PROTAMINE  NDC: 63323-0229-05,63323022905 UPC: 3-63323-22905-4,363323229054 Fresenius Kabi USA LlcOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Protamine Sul 10Mg/Ml Vial 25X5Ml By Fresenius Kabi USA

$351.00$334.99

item No.:RX600460 NDC No.63323022905 UPC No.:363323229054 NDC No. 63323-0229-05 UPC/GTIN No. 3-63323-22905-4 MPN 22905 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx600460 Protamine Sul 10mg/ml Vial 25X5ml by Fresenius Kabi USA Item No. 3600460 NDC No. 63323022905 UPC No. 363323229054 Other Nam

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PROTAMINE SULFATE- protamine sulfate injection, solution
Cardinal Health

For Intravenous Use
BOXED WARNING

Protamine sulfate can cause severe hypotension, cardiovascular collapse, noncardiogenic pulmonary edema, catastrophic pulmonary vasoconstriction, and pulmonary hypertension. Risk factors include high dose or overdose, rapid administration (see WARNINGS and DOSAGE AND ADMINISTRATION), repeated doses, previous administration of protamine, and current or previous use of protamine-containing drugs (NPH insulin, protamine zinc insulin, and certain beta-blockers). Allergy to fish, previous vasectomy, and severe left ventricular dysfunction and abnormal preoperative pulmonary hemodynamics also may be risk factors. In patients with any of these risk factors, the risk to benefit of administration of protamine sulfate should be carefully considered. Vasopressors and resuscitation equipment should be immediately available in case of a severe reaction to protamine. Protamine sulfate should not be given when bleeding occurs without prior heparin use.

DESCRIPTION



Protamines are simple proteins of low molecular weight that are rich in arginine and strongly basic. They occur in the sperm of salmon and certain other species of fish.

Protamine sulfate occurs as fine white or off-white amorphous or crystalline powder. It is sparingly soluble in water. The pH is between 6.0 and 7.0. The cationic hydrogenated protamine at a pH of 6.8 to 7.1 reacts with anionic heparin at a pH of 5.0 to 7.5 to form an inactive complex.

Protamine Sulfate Injection, USP is a sterile, isotonic solution of protamine sulfate. It acts as a heparin antagonist. It is also a weak anticoagulant.

Each mL contains: Protamine sulfate 10 mg; sodium chloride 9 mg; Water for Injection q.s. Sulfuric acid and/or dibasic sodium phosphate (heptahydrate) may have been added for pH adjustment.

The preparation is preservative free.

Protamine sulfate is administered intravenously.

CLINICAL PHARMACOLOGY

When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin (which is strongly acidic), a stable salt is formed and the anticoagulant activity of both drugs is lost.

Protamine sulfate has a rapid onset of action. Neutralization of heparin occurs within five minutes after intravenous administration of an appropriate dose of protamine sulfate. Although the metabolic fate of the heparin-protamine complex has not been elucidated, it has been postulated that protamine sulfate in the heparin-protamine complex may be partially metabolized or may be attacked by fibrinolysin, thus freeing heparin.

INDICATIONS AND USAGE

Protamine Sulfate Injection, USP is indicated in the treatment of heparin overdosage.

NDC 63323-0229-05 UPC/GTIN No.3-63323-22905-4 Mfg.Part No.22905
RX ITEM-Protamine Sul 10Mg/Ml Vial 25X5M
NDC 63323-0229-05 UPC/GTIN No.3-63323-22905-4 Mfg.Part No.22905

BRAND: PROTAMINE  NDC: 63323-0229-05,63323022905 UPC: 3-63323-22905-4,363323229054 Fresenius Kabi USA Llc
Protamine Sul 10Mg/Ml Vial 25X5Ml By Fre
BRAND: PROTAMINE NDC: 63323-0229-05,63323022905 UPC: 3-63323-22905-4,363323229054 Fresenius Kabi USA Llc

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
PROTAMINE SULFATE INTRAVE
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.