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Rx Item-Piroxicam 20Mg Cap 100 By Greenstone Limited

NDC 59762-0145-01 UPC/GTIN No.3-59762-01451-1 Mfg.Part No.14501BRAND: PIROXICAM NDC: 59762-0145-01,59762014501 UPC: 3-59762-01451-1,359762014511 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Piroxicam 20Mg Cap 100 By Greenstone Limited

$448.63$80.39

Item No.: RX355693 NDC No.59762014501 UPC No.:359762014511 NDC No. 59762-0145-01 UPC/GTIN No. 3-59762-01451-1 MPN 14501 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx355693 Piroxicam 20mg Cap 100 by Greenstone Limited Item No. 3355693 NDC No. 59762014501 UPC No. 359762014511 Other Name Piroxica

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PIROXICAM- piroxicam capsule
GENPHARM INC.
Cardiovascular Risk
� NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (See WARNINGS).

� Piroxicam is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (See WARNINGS).

Gastrointestinal Risk



� NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).

DESCRIPTION

Piroxicam is a member of the oxicam group of nonsteroidal anti-inflammatory drugs (NSAIDs). The chemical name for piroxicam is 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Piroxicam occurs as a white crystalline solid, sparingly soluble in water, dilute acid and most organic solvents. It is slightly soluble in alcohols and in aqueous alkaline solution. It exhibits a weakly acidic 4-hydroxy proton (pKa 5.1) and a weakly basic pyridyl nitrogen (pKa 1.8). It has the following structural formula:


Molecular Formula: N3O4S

Molecular Weight: 331.35

Each capsule, for oral administration, contains 10 mg or 20 mg piroxicam. In addition each capsule contains the following inactive ingredients: black iron oxide, corn starch, D&C Yellow #10, FD&C Blue #1, FD&C Blue #2, FD&C Green #3, FD&C Red #40, gelatin, lactose, magnesium stearate, methylparaben, propylparaben, sodium lauryl sulfate, titanium dioxide and other ingredients. In addition to these ingredients, the 10 mg capsules contain yellow iron oxide.

CLINICAL PHARMACOLOGY

Pharmacodynamics

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities in animal models. The mechanism of action of Piroxicam, like that of other NSAID, is not completely understood but may be related to prostaglandin synthetase inhibition.

Pharmacokinetics

Absorption: Piroxicam is well absorbed following oral administration. Drug plasma concentrations are proportional for 10 and 20 mg doses and generally peak within three to five hours after medication. The prolonged half-life (50 hours) results in the maintenance of relatively stable plasma concentrations throughout the day on once daily doses and to significant accumulation upon multiple dosing. A single 20 mg dose generally produces peak piroxicam plasma levels of 1.5 to 2 mcg/mL, while maximum drug plasma concentrations, after repeated daily ingestion of 20 mg piroxicam, usually stabilize at 3 to 8 mcg/mL. Most patients approximate steady state plasma levels within 7 to 12 days. Higher levels, which approximate steady state at two to three weeks, have been observed in patients in whom longer plasma half-lives of piroxicam occurred.

With food there is a slight delay in the rate but not the extent of absorption following oral administration. The concomitant administration of antacids (aluminum hydroxide or aluminum hydroxide with magnesium hydroxide) have been shown to have no effect on the plasma levels of orally administered piroxicam.

Distribution: The apparent volume of distribution of piroxicam is approximately 0.14L/kg. Ninety-nine percent of plasma piroxicam is bound to plasma proteins. Piroxicam is excreted into human milk. The presence in breast milk has been determined during initial and long-term conditions (52 days). Piroxicam appeared in breast milk at about 1% to 3% of the maternal concentration. No accumulation of piroxicam occurred in milk relative to that in plasma during treatment.

Metabolism: Metabolism of piroxicam occurs by hydroxylation at the 5 position of the pyridyl side chain and conjugation of this product; by cyclodehydration; and by a sequence of reactions involving hydrolysis of the amide linkage, decarboxylation, ring contraction, and N-demethylation. The biotransformation products of piroxicam metabolism are reported to not have any anti-inflammatory activity.

Excretion: Piroxicam and its biotransformation products are excreted in urine and feces, with about twice as much appearing in the urine as in the feces. Approximately 5 % of a piroxicam dose is excreted unchanged. The plasma half-life (T1/2) for piroxicam is approximately 50 hours.

NDC 59762-0145-01 UPC/GTIN No.3-59762-01451-1 Mfg.Part No.14501
RX ITEM-Piroxicam 20Mg Cap 100 By Greens
NDC 59762-0145-01 UPC/GTIN No.3-59762-01451-1 Mfg.Part No.14501

BRAND: PIROXICAM NDC: 59762-0145-01,59762014501 UPC: 3-59762-01451-1,359762014511
Piroxicam 20Mg Cap 100 By Greenstone Lim
BRAND: PIROXICAM NDC: 59762-0145-01,59762014501 UPC: 3-59762-01451-1,359762014511

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
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Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.