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RX ITEM-Paliperidone 3Mg Tab 30 By Actavis Pharma

Paliperidone 3Mg Tab 30 By Actavis Pharmaitem No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330  UPC/GTIN No. 3-05913-69330-2 MPN 369330 Paliperidone 3Mg Tab 30 By Actavis Pharma item No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330  UPC/GTIN No. 3-05913-69330-2 MPN 369330 BRAND: PALIPERIDONE NDC: 00591-3693-30,591369330 UPC: 3-05913-69330-2,305913693302 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comNDC 00591-3693-30 UPC/GTIN No.3-05913-69330-2 Mfg.Part No.369330 Brand Equivalent: INVEGA 3MG
NDC: 00591369330UPC: 305913693302
Item: 453337
Size: 30
Form: TABLET
Manufacturer: TEVAVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

RX ITEM-Paliperidone 3Mg Tab 30 By Actavis Pharma

$917.88$499.00

item No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330 UPC/GTIN No. 3-05913-69330-2 MPN 369330 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX item. Rx Item No. Rx468512 Paliperidone 3mg Tab 30 by Actavis Pharma Item No. 3468512 NDC No. 00591369330 UPC No

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INVEGA- paliperidone tablet, extended release
Janssen Pharmaceuticals, Inc.

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. INVEGA� (paliperidone) Extended-Release Tablets is not approved for the treatment of patients with dementia-related psychosis. [see Warnings and Precautions (5.1)]

1 INDICATIONS AND USAGE

1.1 Schizophrenia


INVEGA� (paliperidone) Extended-Release Tablets are indicated for the treatment of schizophrenia [see Clinical Studies (14.1)].

The efficacy of INVEGA� in schizophrenia was established in three 6-week trials in adults and one 6-week trial in adolescents, as well as one maintenance trial in adults.

1.2 Schizoaffective Disorder
INVEGA� (paliperidone) Extended-Release Tablets are indicated for the treatment of schizoaffective disorder as monotherapy and an adjunct to mood stabilizers and/or antidepressant therapy [see Clinical Studies (14.2)].

The efficacy of INVEGA� in schizoaffective disorder was established in two 6-week trials in adults.

2 DOSAGE AND ADMINISTRATION

2.1 Schizophrenia
Adults

The recommended dose of INVEGA� (paliperidone) Extended-Release Tablets for the treatment of schizophrenia in adults is 6 mg administered once daily. Initial dose titration is not required. Although it has not been systematically established that doses above 6 mg have additional benefit, there was a general trend for greater effects with higher doses. This must be weighed against the dose-related increase in adverse reactions. Thus, some patients may benefit from higher doses, up to 12 mg/day, and for some patients, a lower dose of 3 mg/day may be sufficient. Dose increases above 6 mg/day should be made only after clinical reassessment and generally should occur at intervals of more than 5 days. When dose increases are indicated, increments of 3 mg/day are recommended. The maximum recommended dose is 12 mg/day.
DOSAGE FORMS AND STRENGTHS

INVEGA� Extended-Release Tablets are available in the following strengths and colors: 1.5 mg (orange-brown), 3 mg (white), 6 mg (beige), and 9 mg (pink). All tablets are capsule shaped and are imprinted with either "PAL 1.5?, "PAL 3?, "PAL 6?, or "PAL 9?.
CLINICAL PHARMACOLOGY

12.1 Mechanism of Action


Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2 ) and serotonin Type 2 (5HT2A ) receptor antagonism.

Paliperidone 3Mg Tab 30 By Actavis Pharmaitem No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330  UPC/GTIN No. 3-05913-69330-2 MPN 369330
Paliperidone 3Mg Tab 30
Paliperidone 3Mg Tab 30 By Actavis Pharmaitem No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330 UPC/GTIN No. 3-05913-69330-2 MPN 369330

Paliperidone 3Mg Tab 30 By Actavis Pharma item No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330  UPC/GTIN No. 3-05913-69330-2 MPN 369330
Paliperidone 3Mg Tab 30 By
Paliperidone 3Mg Tab 30 By Actavis Pharma item No.:RX468512/a NDC No.591369330 UPC No.:305913693302 NDC No. 00591-3693-30 0591-3693-30 0591369330 00591369330 UPC/GTIN No. 3-05913-69330-2 MPN 369330

BRAND: PALIPERIDONE NDC: 00591-3693-30,591369330 UPC: 3-05913-69330-2,305913693302
Paliperidone 3Mg Tab 30 By Actavis Pharm
BRAND: PALIPERIDONE NDC: 00591-3693-30,591369330 UPC: 3-05913-69330-2,305913693302

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
Click above for Invega
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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NDC 00591-3693-30 UPC/GTIN No.3-05913-69330-2 Mfg.Part No.369330 Brand Equivalent: INVEGA 3MG
NDC: 00591369330UPC: 305913693302
Item: 453337
Size: 30
Form: TABLET
Manufacturer: TEVA
RX ITEM-Paliperidone 3Mg Tab 30 By Actav
NDC 00591-3693-30 UPC/GTIN No.3-05913-69330-2 Mfg.Part No.369330 Brand Equivalent: INVEGA 3MG NDC: 00591369330UPC: 305913693302 Item: 453337 Size: 30 Form: TABLET Manufacturer: TEVA

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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