NUTRILYTE II- potassium acetate, sodium chloride, sodium acetate, magnesium chloride and calcium chloride injection, solution, concentrate
American Regent, Inc.
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Rx Only
Not for direct infusion. For prescription compounding of intravenous admixtures only. Concentrated solution. Dilute to appropriate strength with suitable intravenous fluid prior to administration.
DESCRIPTION
Nutrilyte II (Multi-Electrolyte Concentrate) is a sterile, nonpyrogenic, concentrated solution of intra- and extracellular electrolytes, excluding phosphate. No antimicrobial agent has been added.
It is available in a 20 mL single dose preparation and a 100 mL Pharmacy Bulk Package.
The 100 mL Pharmacy Bulk Package contains many doses for use in a pharmacy admixture program in the preparation of parenteral fluids. See directions for dispensing from the 100 mL Pharmacy Bulk Package.
Electrolytes (mEq): per mL Per 20 mL
Acetate 1.475 29.5
Potassium 1 20
Chloride 1.75 35
Sodium 1.75 35
Magnesium 0.25 5
Calcium 0.225 4.5
Nutrilyte II contains: per mL per 20 mL
Potassium Acetate, USP 98 mg 1.96 grams
Sodium Chloride, USP 74.5 mg 1.49 grams
Sodium Acetate 3H2 O, USP 64.6 mg 1.292 grams
Magnesium Chloride 6H2 O, USP 25.5 mg 0.51 gram
Calcium Chloride 2H2 O, USP 16.55 mg 0.331 gram
Water for Injection, USP q.s. q.s.
pH (6.3 to 7.0) adjusted with Glacial Acetic Acid when necessary.
Calculated Osmolarity: Approximately 6212 mOsmol/Liter; 6.2 mOsmol/mL.
CLINICAL PHARMACOLOGY
Nutrilyte II Concentrate provides a source of intra- and extracellular electrolytes in suitable amounts, to help maintain normal cellular metabolism during total parenteral nutrition (TPN) and other parenteral therapy in adults. Use of properly diluted Nutrilyte II meets most adult daily electrolyte requirements and provides adjunctive therapy for replenishment of depleted electrolyte stores.
Intracellular : Potassium, the principal intracellular cation, maintains the integrity of the cellular membrane, helps transport dextrose across the cell membrane and contributes to normal renal function: Magnesium, the second most concentrated intracellular cation, acts as an important cofactor in enzymatic reactions and helps to maintain normal central nervous system activity and amino acid utilization. Calcium participates in the maintenance of normal neuromuscular functions and blood coagulation.
Extracellular : Chloride, the primary extracellular anion, contributes to the maintenance of acid-base balance. Sodium, the principal extracellular cation, acts in conjunction with potassium to maintain integrity of the cell membrane. Sodium also helps to maintain motor nerve depolarization, normal renal metabolism and fluid balance. Acetate is a bicarbonate alternate and an important intermediate in the tricarboxylic acid cycle.
INDICATIONS AND USAGE
Nutrilyte II Concentrate is indicated for use as a supplement to parenteral nutritional solutions containing amino acids, dextrose and/or other calorie sources delivered by central venous or peripheral infusion to facilitate amino acid utilization and maintain electrolyte balance in adults.
Nutrilyte II Concentrate is also indicated as a source of replacement electrolytes for the depleted adult patient during parenteral therapy.