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Rx Item-Nitroglycerin Tran 0.4Mg Hr Patch 30 By Mylan Pharma

NDC 00378-9112-93 UPC/GTIN No.3-03789-11293-4 Mfg.Part No.911293BRAND: NITROGLYCERIN NDC: 00378-9112-93,378911293 UPC: 3-03789-11293-4,303789112934 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Nitroglycerin Tran 0.4Mg Hr Patch 30 By Mylan Pharma

$65.18$27.98

Item No.:RX365940 NDC No.378911293 UPC No.:303789112934 NDC No. 00378-9112-93 UPC/GTIN No. 3-03789-11293-4 MPN 911293 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx365940 Nitroglycerin Tran 0.4mg/Hr Patch 30 by Mylan Pharma Item No. 3365940 NDC No. 00378911293 UPC No. 303789112934 Other Nam

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NITRO-DUR- nitroglycerin patch
Merck Sharp & Dohme Corp.

DESCRIPTION

Nitroglycerin is 1,2,3-propanetriol trinitrate. molecular weight is 227.09. The organic nitrates are vasodilators, active on both arteries and veins.

The NITRO-DUR� (nitroglycerin) Transdermal Infusion System is a flat unit designed to provide continuous controlled release of nitroglycerin through intact skin. The rate of release of nitroglycerin is linearly dependent upon the area of the applied system; each cm2 of applied system delivers approximately 0.02 mg of nitroglycerin per hour. Thus, the 5-, 10-, 15-, 20-, 30-, and 40-cm2 systems deliver approximately 0.1, 0.2, 0.3, 0.4, 0.6, and 0.8 mg of nitroglycerin per hour, respectively.



The remainder of the nitroglycerin in each system serves as a reservoir and is not delivered in normal use. After 12 hours, for example, each system has delivered approximately 6% of its original content of nitroglycerin.

The NITRO-DUR transdermal system contains nitroglycerin in acrylic-based polymer adhesives with a resinous cross-linking agent to provide a continuous source of active ingredient. Each unit is sealed in a paper polyethylene-foil pouch.

Cross section of the system.

image of system cross section
(click image for full-size original)
CLINICAL PHARMACOLOGY

The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.

Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testing to assess the antianginal efficacy of continuously delivered nitrates. In the large majority of these trials, active agents were indistinguishable from placebo after 24 hours (or less) of continuous therapy. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed. Only after nitrates have been absent from the body for several hours has their antianginal efficacy been restored. NITRO-DUR Indications and Usage

Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of transdermal nitroglycerin is not sufficiently rapid for this product to be useful in aborting an acute attack. DOSAGE AND ADMINISTRATION

The suggested starting dose is between 0.2 mg/hr 1 and 0.4 mg/hr 1. Doses between 0.4 mg/hr 1 and 0.8 mg/hr 1 have shown continued effectiveness for 10 to 12 hours daily for at least 1 month (the longest period studied) of intermittent administration. Although the minimum nitrate-free interval has not been defined, data show that a nitrate-free interval of 10 to 12 hours is sufficient (see CLINICAL PHARMACOLOGY). Thus, an appropriate dosing schedule for nitroglycerin patches would include a daily patch-on period of 12 to 14 hours and a daily patch-off period of 10 to 12 hours.

NDC 00378-9112-93 UPC/GTIN No.3-03789-11293-4 Mfg.Part No.911293
RX ITEM-Nitroglycerin Tran 0.4Mg Hr Patc
NDC 00378-9112-93 UPC/GTIN No.3-03789-11293-4 Mfg.Part No.911293

BRAND: NITROGLYCERIN NDC: 00378-9112-93,378911293 UPC: 3-03789-11293-4,303789112934
Nitroglycerin Tran 0.4Mg Hr Patch 30 By
BRAND: NITROGLYCERIN NDC: 00378-9112-93,378911293 UPC: 3-03789-11293-4,303789112934

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
NITROGLYCERIN TRANSDERM P
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.