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Rx Item-Muse 125Mcg Alprostadil Suppository 6 By Meda Pharma

NDC 00037-8110-06 UPC/GTIN No.3-00378-11006-7 Mfg.Part No.811006BRAND: MUSE NDC: 00037-8110-06,37811006 UPC: 3-00378-11006-7,300378110067 Meda PharmaceuticalsOnly Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Muse 125Mcg Alprostadil Suppository 6 By Meda Pharma

$468.85$446.53

Item No.:RX141907 NDC No.37811006 UPC No.:300378110067 NDC No. 00037-8110-06 UPC/GTIN No. 3-00378-11006-7 MPN 811006 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx141907 Muse 125mcg Sup 6 by Meda Pharma Item No. 3141907 NDC No. 00037811006 UPC No. 300378110067 Other Name Muse, ALPROSTADIL URETH

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MUSE- alprostadil suppository
Meda Pharmaceuticals Inc.

DESCRIPTION

MUSE� (alprostadil) is a single-use, medicated transurethral system for the delivery of alprostadil to the male urethra. Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet (micro-suppository measuring 1.4 mm in diameter by 3 mm or 6 mm in length) that resides in the tip of a translucent hollow applicator. MUSE is administered by inserting the applicator stem into the urethra after urination. The pellet containing alprostadil is delivered by depressing the applicator button (see Figure 1). The components of the delivery system are constructed of medical grade polypropylene. Each MUSE system is packaged in an individual foil pouch. Diagram of the MUSE Transurethral System
The active ingredient in MUSE is alprostadil, which is chemically identical to the naturally occurring eicosanoid, prostaglandin E1 (PGE1 ). The chemical name for alprostadil is prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-(11?,13E,15S)-(1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxo-cyclopentane heptanoic acid, and the molecular weight is 354.49. The empirical formula is C20 H34 O5 . The structural formula of alprostadil is represented below:

Structural Formula
Alprostadil is a white to off-white crystalline powder with a melting point between 115� and 116�C. Its solubility at 35�C is 8000 mcg per 100 mL double-distilled water. The inactive ingredient in MUSE is polyethylene glycol 1450, USP. There are no other active agents or excipients in MUSE.

MUSE is available in 4 dosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg.

CLINICAL PHARMACOLOGY

Mechanism of Action: Prostaglandin E1 is a naturally occurring acidic lipid that is synthesized from fatty acid precursors by most mammalian tissues and has a variety of pharmacologic effects. Human seminal fluid is a rich source of prostaglandins, including PGE1 and PGE2 , and the total concentration of prostaglandins in ejaculate has been estimated to be approximately 100�200 mcg/mL. In vitro, alprostadil (PGE1 ) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. Additionally, vasodilation has been demonstrated in isolated cavernosal artery segments that were pre-contracted with either norepinephrine or prostaglandin F2 ? . When alprostadil was injected into the corpus cavernosum of pigtail monkeys in vivo, dose-dependent increases in cavernosal artery blood flow were observed. INDICATIONS AND USAGE

MUSE is indicated for the treatment of erectile dysfunction. Studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with similarly administered placebo.

NDC 00037-8110-06 UPC/GTIN No.3-00378-11006-7 Mfg.Part No.811006
RX ITEM-Muse 125Mcg Suppository 6 By Med
NDC 00037-8110-06 UPC/GTIN No.3-00378-11006-7 Mfg.Part No.811006

BRAND: MUSE NDC: 00037-8110-06,37811006 UPC: 3-00378-11006-7,300378110067 Meda Pharmaceuticals
Muse 125Mcg Suppository 6 By Meda Pharma
BRAND: MUSE NDC: 00037-8110-06,37811006 UPC: 3-00378-11006-7,300378110067 Meda Pharmaceuticals

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
ALPROSTADIL URETHRAL SUPP
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
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Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.