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Rx Item-Mesnex 400Mg Tab 10 By Baxter Pharma Gen Mesna

Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scopWant to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.comVisit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.

Rx Item-Mesnex 400Mg Tab 10 By Baxter Pharma Gen Mesna

$943.09$799.99

Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509 Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,ResearchCo.,Uni.,VA,Vet & Wholesalers in scope of practice can order this RX Item. Rx Item No. Rx651582 Mesnex 400mg Tab 10 by Baxter Acc Item No. 3651582 NDC No. 67108356509

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Clinical Information
Gen. Code and Des.
23545 mesna ORAL TABLET 400 MG
GCN and Des.
38953 mesna ORAL TABLET 400 MG
Strength
400MG
Dose Form
TABLET
Product Category
RX Pharmaceuticals
Fine Line Class
850085008510 All Rx Products
DEA Class
NC
OMP Family

AHFS Class
92560000 PROTECTIVE AGENTS
Active Ingredients
2678 mesna 19767454
Inactive Ingredients
2432 lactose 64044515
2537 povidone 9003398





MESNA - mesna injection, solution
Fresenius Kabi USA, LLC


1 INDICATIONS AND USAGE

Mesna injection is indicated as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.
Limitation of Use:Mesna injection is not indicated to reduce the risk of hematuria due to other pathological conditions such as thrombocytopenia.

2 DOSAGE AND ADMINISTRATION

2.1 Intravenous Dosing
Mesna injection may be given on a fractionated dosing schedule of three bolus intravenous injections as outlined below.



Mesna injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of mesna injection is 60% of the ifosfamide dose Intravenous and Oral Dosing

Mesna injection may be given on a fractionated dosing schedule of a single bolus injection followed by two oral administrations of mesna tablets as outlined below. Mesna injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration. Mesna tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide. The total daily dose of mesna is 100% of the ifosfamide dose. DESCRIPTION

Mesna Injection is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. The active ingredient, mesna, is a synthetic sulfhydryl compound designated as sodium-2-mercaptoethane sulfonate with a molecular formula of C2 H5 NaO3 S2 and a molecular weight of 164.18. Its structural formula is as follows:
HS�CH2 �CH2 SO3 �Na+ Mesna injection is a sterile, nonpyrogenic, aqueous solution of clear and colorless appearance in clear glass multiple dose vials for intravenous administration. Mesna injection contains 100 mg/mL mesna, 0.25 mg/mL edetate disodium and sodium hydroxide for pH adjustment. Mesna injection multiple dose vials also contain 10.4 mg/mL of benzyl alcohol as a preservative. The solution has a pH range of 6.5 to 8.5.

12 CLINICAL PHARMACOLOGY

12.1 Mechanism of Action
Mesna reacts chemically with the urotoxic ifosfamide metabolites, acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. The first step in the detoxification process is the binding of mesna to 4-hydroxy-ifosfamide forming a non-urotoxic 4-sulfoethylthioifosfamide. Mesna also binds to the double bonds of acrolein and to other urotoxic metabolites and inhibits their effects on the bladder.

Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509
RX ITEM-Mesnex 400Mg Tab 10 By Baxter Ph
Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509

Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509
Mesnex 400Mg Tab 10 By Baxter Pharma
Item No.:RX651582 NDC No.67108356509 67108-3565-9 6710835659 UPC No.:367108356591 NDC No. 67108-3565-09 UPC/GTIN No. 3-67108-35659-1 367108356591 367108-356591 MPN 356509

Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop
MESNA ORAL TABLET 400 MG
Only Lic.-Physician,Pharmacy,Dentist,Drug Mfg,Dist.,Gov,Hospital,Lic.Lab,Naturalist,Naturopath,NP,Optometrist,Pharmacist,PA,Physical Therapist,Podiatrist,Research Co.,Uni.,VA,Vet & Wholesalers in scop

Want to do Research on this Med or need a large quantity? Email Details with quantity required to:sales@AmericanPharmaWholesale.com
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Want to do Research on this Med or need a large quantity? Email Details with quantity required to:[email protected]

Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.
AmericanPharmaWholesale.com
Visit AmericanPharmaWholesale.com for over 100,000 items of Health & Beauty at Retail@Wholesale prices.